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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-MAY-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 6A-10
  • locus tag: HKM25_2194 [new locus tag: HKM25_RS10690 ]
  • pan locus tag?: PNEUPAN003768000
  • symbol: HKM25_2194
  • pan gene symbol?: ctpC
  • synonym:
  • product: heavy metal translocating P-type ATPase family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HKM25_2194 [new locus tag: HKM25_RS10690 ]
  • symbol: HKM25_2194
  • product: heavy metal translocating P-type ATPase family protein
  • replicon: chromosome
  • strand: -
  • coordinates: 2071779..2073776
  • length: 1998
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: CP053210 (2071779..2073776) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1927 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    TTGGATATTCAAGACTATCTTCGTTCCTTGGCGAGAGATGAAAAGGGGATTGAGTCTATC
    CAGTTTTACATGGATCAACAGCACTTTACTCTACGCATAAAAGAAGGCTTTTCTGTATTA
    GATAATGCAGAAGCCTTTTTAAAAAGAATTGATAAAGGGAAAGTTTCTGAGTTGATGACT
    CTTCCCATTCGTAGAGAAGAGAGTGCTTATTCTATTGTTTCAGGTGCAGCGGTTAAGCGT
    GTACTTTTTCGTAGTTTTGTGCCGTATCCTATTCGCTATATATGGACTTGTTATCAGGCT
    TTGGGTTATATTAGAGAAGCCTATCAAACACTAGCGCGTAAGGAACTAACGATGGAAATC
    TTGGACTGTTCGGCTATTTTATTGTCTTTGTTTATGAACCAATCCAAGACAGCTAGCAAT
    ATCATGTTTATGCTTGATTTGGGGAATCATTTAGATCAGTGGTCCTTGAAAAAAACTGCA
    ACAGATTTAGAACAGAGTCTTCTTGCAAAAGAGAGCGATGTATTCCTAGTACAGGGCGAT
    ACGGTTGTTAGTATCAAGAGTTCCGATGTTCAAATAGGAGATGTCTTGATCTTATCTCAA
    GGAAATGAAATTCTGTTTGATGGACAAGTAGTTTCAGGTTTAGGTATGGTCAACGAAAGT
    TCCTTGACAGGAGAGAGTTTTCCAGTTGAAAAAAGAGAGTCTGATTTGGTTTGTGCAAAT
    ACAGTATTAGAAACTGGAGAGTTACGCATTCGTGTAACAGATAATCAGATGAACAGCCGT
    CTTTTACAGCTGATTGAGTTGATGAAGAAATCTGAAGAAAACAAGAAAACGAAACAACGC
    TATTTCATCAAGATGGCGGATAAAGTCGTCAAATATAATTTCTTGGGGGCTGGGCTGACT
    TACCTATTGACAGGTTCTTTTTCTAAGGCTATTTCTTTCCTATTGGTCGATTTCTCCTGC
    GCTTTGAAAATCTCTACTCCTGTAGCTTATTTGACAGTTATCAAGGAAGGGTTGAACCGT
    GAAATGGTGATTAAGGATGGAGATGTTCTGGAGAAATATCTGGAAGTTGATACTTTCTTG
    TTTGATAAGACAGGAACAATCACAACTAGTTATCCTATAGTTGAAAAGGTGTTACCTTTT
    GGAGACTATAGTGAGGAAGACATTCTCAGAATCAGTGCCTGTCTTGAGGAACACATTTAT
    CATCCTATTGCTAATGCCATCGTCAAGCAAGCTGAGATAGAGGGAATTGAACATGAGGAA
    ATGCATGGGAAACTCCAATATATCGCAAGCAAGGGGATCAAATCTCATATAGATGGCCAA
    CCAGTTCTTATTGGGAATTATGTCTTGATGCAGGATGAGCAGATTCATATCAGTTCAGAA
    CAAAATGCTTTAATTGAAGAGTACAAGAGTCACTACAATCTCTTATTCTTGGCTTATCAA
    AATGAATTGATTGGAATGTTCTGCATTCATACTCCTTTGAGAAAAGAAGCAAAAACAGCC
    TTGGATAAACTTAAGGCACAGGGGAAAAAATTGATTCTGGCAACAGGAGACACCTTGATT
    AGGACAGAGGAATTAGTCAAAGATTTGCCCTTTGATCAGGTCTATACAGACTTGAAACCT
    GATGGGAAATTTGAGTTAGTAGAGAAACTGCAGAAAGCAGGTCACACTATTTTGATGGTT
    GGAGATGGATTGAATGACTCAGCGGCTCTAACTCTATCAGATATCGGTGTGGTGATGAAT
    GAGAGTGCAGATATTTCTAAGCAGATGAGTGATATCTTATTGTTAGATAATCGTTTGGAT
    TTCTTCCAAGAGTTGGATTCGTTATCATCATCTTTGCAAACACTCATCAAGAAAAATATT
    CAAGATACCGTTGTCGTAAATAGTAGTTTGATTGGCTTCGGCTTATTTAATTGGCTCAGT
    CCTTCAAATCTCTCTATCTTACATAATCTAACAACCTTGCGCATTGTCCTGCGTAGCCTG
    TCTATTAAAAATAGATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    1998

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HKM25_2194 [new locus tag: HKM25_RS10690 ]
  • symbol: HKM25_2194
  • description: heavy metal translocating P-type ATPase family protein
  • length: 665
  • theoretical pI: 5.12776
  • theoretical MW: 75028.1
  • GRAVY: -0.0484211

⊟Function[edit | edit source]

  • TIGRFAM:
    heavy metal translocating P-type ATPase (TIGR01525; EC 3.6.3.-; HMM-score: 523.9)
    and 18 more
    Metabolism Transport and binding proteins Cations and iron carrying compounds cadmium-translocating P-type ATPase (TIGR01512; EC 3.6.3.3; HMM-score: 285.6)
    Cellular processes Cellular processes Detoxification copper-translocating P-type ATPase (TIGR01511; EC 3.6.3.4; HMM-score: 266.9)
    Metabolism Transport and binding proteins Cations and iron carrying compounds copper-translocating P-type ATPase (TIGR01511; EC 3.6.3.4; HMM-score: 266.9)
    HAD ATPase, P-type, family IC (TIGR01494; EC 3.6.3.-; HMM-score: 261.3)
    plasma-membrane proton-efflux P-type ATPase (TIGR01647; EC 3.6.3.6; HMM-score: 113.3)
    Metabolism Transport and binding proteins Cations and iron carrying compounds K+-transporting ATPase, B subunit (TIGR01497; EC 3.6.3.12; HMM-score: 107.9)
    calcium-translocating P-type ATPase, PMCA-type (TIGR01517; EC 3.6.3.8; HMM-score: 86.8)
    P-type ATPase of unknown pump specificity (type V) (TIGR01657; HMM-score: 80.4)
    Metabolism Transport and binding proteins Cations and iron carrying compounds magnesium-translocating P-type ATPase (TIGR01524; EC 3.6.3.2; HMM-score: 71.5)
    calcium-transporting P-type ATPase, PMR1-type (TIGR01522; EC 3.6.3.8; HMM-score: 63)
    Metabolism Energy metabolism ATP-proton motive force interconversion Na,H/K antiporter P-type ATPase, alpha subunit (TIGR01106; EC 3.6.3.-; HMM-score: 54.9)
    Metabolism Transport and binding proteins Cations and iron carrying compounds calcium-translocating P-type ATPase, SERCA-type (TIGR01116; EC 3.6.3.8; HMM-score: 54.8)
    potassium/sodium efflux P-type ATPase, fungal-type (TIGR01523; EC 3.6.3.-; HMM-score: 47.5)
    Unknown function Enzymes of unknown specificity Cof-like hydrolase (TIGR00099; HMM-score: 31.9)
    sucrose-phosphate phosphatase subfamily (TIGR01482; EC 3.1.3.-; HMM-score: 23.3)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIB (TIGR01484; HMM-score: 17)
    Metabolism Central intermediary metabolism Other 2,3-diketo-5-methylthio-1-phosphopentane phosphatase (TIGR01489; HMM-score: 16.5)
    phosphoglycolate phosphatase, TA0175-type (TIGR01487; EC 3.1.3.18; HMM-score: 12.3)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    HAD (CL0137) Hydrolase; haloacid dehalogenase-like hydrolase (PF00702; HMM-score: 107.7)
    no clan defined E1-E2_ATPase; E1-E2 ATPase (PF00122; HMM-score: 105.7)
    and 3 more
    HAD (CL0137) Hydrolase_3; haloacid dehalogenase-like hydrolase (PF08282; HMM-score: 33.8)
    HAD_2; haloacid dehalogenase-like hydrolase (PF13419; HMM-score: 12.1)
    NADP_Rossmann (CL0063) CoA_binding_3; CoA-binding domain (PF13727; HMM-score: 12)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.04
    • Cytoplasmic Membrane Score: 9.96
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0001
    • Cytoplasmic Membrane Score: 0.9991
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0008
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001275
    • TAT(Tat/SPI): 0.000421
    • LIPO(Sec/SPII): 0.00029
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: QJS37842 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MDIQDYLRSLARDEKGIESIQFYMDQQHFTLRIKEGFSVLDNAEAFLKRIDKGKVSELMTLPIRREESAYSIVSGAAVKRVLFRSFVPYPIRYIWTCYQALGYIREAYQTLARKELTMEILDCSAILLSLFMNQSKTASNIMFMLDLGNHLDQWSLKKTATDLEQSLLAKESDVFLVQGDTVVSIKSSDVQIGDVLILSQGNEILFDGQVVSGLGMVNESSLTGESFPVEKRESDLVCANTVLETGELRIRVTDNQMNSRLLQLIELMKKSEENKKTKQRYFIKMADKVVKYNFLGAGLTYLLTGSFSKAISFLLVDFSCALKISTPVAYLTVIKEGLNREMVIKDGDVLEKYLEVDTFLFDKTGTITTSYPIVEKVLPFGDYSEEDILRISACLEEHIYHPIANAIVKQAEIEGIEHEEMHGKLQYIASKGIKSHIDGQPVLIGNYVLMQDEQIHISSEQNALIEEYKSHYNLLFLAYQNELIGMFCIHTPLRKEAKTALDKLKAQGKKLILATGDTLIRTEELVKDLPFDQVYTDLKPDGKFELVEKLQKAGHTILMVGDGLNDSAALTLSDIGVVMNESADISKQMSDILLLDNRLDFFQELDSLSSSLQTLIKKNIQDTVVVNSSLIGFGLFNWLSPSNLSILHNLTTLRIVLRSLSIKNR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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