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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 6A-10
  • locus tag: HKM25_RS04135 [old locus tag: HKM25_847 ]
  • pan locus tag?: PNEUPAN001837000
  • symbol: HKM25_RS04135
  • pan gene symbol?: —
  • synonym:
  • product: ABC transporter ATP-binding protein/permease

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HKM25_RS04135 [old locus tag: HKM25_847 ]
  • symbol: HKM25_RS04135
  • product: ABC transporter ATP-binding protein/permease
  • replicon: chromosome
  • strand: +
  • coordinates: 812650..814734
  • length: 2085
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP053210 (812650..814734) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    ATGTTCGAAATTAGAAATTTGAGTCTCTCTTTTGCAGGCAGGCGGTTGCTAGAGCCAACA
    GATTTGATATTTGAAAGGGGAAAAGTATATACAATATATGGGAAGTCAGGCGTAGGAAAG
    TCTTCTTTACTGAATAAAATTGGTTTGCTCTCTGCTACGGATCCTAGTGTTTCTTATTTC
    TTCGATGGAAAAGAGATTGATATCGAAAATAAGAAATCAGTCTCTGTCTTTATAGCTGAA
    GAAGTTGCCTTTGTATTTCAGGGGCGAAATCTAATAAATGATTTGACCGTATTTGAAAAT
    TTAAGACTAGCTTTAAACTTTTATGACTTGAGTCCAGATGAAATAGAAAGCAAAATTGAT
    ACAGTATTGGCGGATTTACAGATTTCTTCTTTAAAGCATGCTTATCCAGAAGATTTATCC
    GGTGGTGAAGAACAACGAGTGGCAATCGCAAGAGCCTTAGTTACAGGAAAGACTCTCATC
    TTAGCTGATGAACCAACAAGTTCTTTGGATAAAGAAAATAGAGAAAAAGTCTCCGCCTTG
    TTAATTGATTTAGCTCACAAATATCATAAAATTGTATTGATTGTTTCGCATGATGAGGCG
    ATGATTGCAATAGGAGATGTTCAGCTTCATTTTAAAGACCATAAATTAGTTGGGAATTGT
    CTTATTTTGAATTCTGATGAAGGGATAAAGGATTCTAAGAAGTGGTCCTCCTGTTTGTCG
    TCTTCTCATACGAAGCTATCCGTTTTGAAACATAGAAGGCCTTTTTTACCTAGATTATTA
    GCGTTTTTTATCTCTCTTGTAGTTGCTATAGCAGTAACCTCTATTAACTTTCAGTCCTTA
    TTTGCAGATAAGTATCACCAACTGGTGAACAACTCACTCGAAAATGGCTTCTTGGTGATT
    AATGATTCGCTTCATTTACAAACTACAAAAGTGTTGGATGATTTTCTCAGTTTTGATAAG
    GAGGAAATCACCTCAATTAGCACAAGTCAGAATATTCAAACCGTCAATCCTTATATAGAG
    TTTCTCTCTTTGGGTATGACGTTTGATAATTCAAAAGACTATTCACAACTTCAAAAGAAC
    TTTCAGCCAACTTTGACTATTGATGGTCAGACCAGAAGCTTGACAAGAAATTTTTCAATT
    CAACCCTTGTATCAGACAAATACAACACAGAGGCAGATAGAGTATTTTGATAGGAGCAAT
    GAAAAAGGGATTTATCTATCTGAGCAATTCATTTCAGATGAAAAATTACCAAATATAGTT
    TCGGGAACTACCGTGACACTGACTTTTTATATTCCAATTTCTTTATATGAATCAAGTATA
    GAGAAAGAGGGGAATATATTGAAAGGAGATGGCGATTTATTTGTCAAAGTGGATAAAACA
    TATCCTGTTTTAGGGATTGTTAAAAAAAGTTATCCGTTTGAATATTCCCCTTATGGGAAC
    ACCCTATTTATGAATATTGCTGAAATGGAAGAATTGCAAAATGAAGCAATTCAACAGCAT
    CCCATGACGAAGATGGCTTTAGATGGTTTTCCTTTGAAATCATGGATGCCGAGTGCGATT
    CATGTGTTACTAAAGGATAGCGGTGCTATTCCTGAAGAATTGAGTAGAATAAGAGCAATC
    TCTTCACAAATTACTATTTTATCATCATATGAAAACTACGAAGAATTTAATAAAGGACTC
    ACCTATATCAGGCAATTTTTAATGTTGCTATCCCTAGTCTTACTCATCCTTGTCATCGCA
    GTATTGTCCTTTGTTTTCTTTTTGCTCAATCGTCCTCGACGCTTTGAAGTAGGGATTTTA
    AAATCTTTGGGATACAGTACTCAAAATATTGTTTGGCTTTTCTTAAAAGAATTAATTGGT
    TATGGTAAAACAATTTCGATATTAGCAAGTTGTTTACTCGTCATTCTTTCCATTTTAGCA
    ATGCAAGTGCTTAAATTGGAAATTTCAGATGTTTTTAAATTCTATCTAACTTCCGTTTTC
    ACCTTAATTGGATTATCAGTCTCAGTACTGATAATAAGTGGCTTACTACCTATATACACA
    ACTTGTAGGCAAACAGTTGTCGATACTATCCGAAAGAATGGATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2085

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HKM25_RS04135 [old locus tag: HKM25_847 ]
  • symbol: HKM25_RS04135
  • description: ABC transporter ATP-binding protein/permease
  • length: 694
  • theoretical pI: 6.12777
  • theoretical MW: 78296.9
  • GRAVY: 0.103458

⊟Function[edit | edit source]

  • reaction:
    EC 7.5.2.-?  ExPASy
  • TIGRFAM:
    Cellular processes Cellular processes Toxin production and resistance putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 169.9)
    Metabolism Transport and binding proteins Unknown substrate putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 169.9)
    and 71 more
    Genetic information processing Protein fate Protein and peptide secretion and trafficking lipoprotein releasing system, ATP-binding protein (TIGR02211; EC 3.6.3.-; HMM-score: 133.3)
    Cellular processes Cellular processes Cell division cell division ATP-binding protein FtsE (TIGR02673; HMM-score: 128.4)
    ABC exporter ATP-binding subunit, DevA family (TIGR02982; HMM-score: 128.2)
    Metabolism Transport and binding proteins Anions phosphonate ABC transporter, ATP-binding protein (TIGR02315; EC 3.6.3.28; HMM-score: 108.4)
    Metabolism Transport and binding proteins Anions sulfate ABC transporter, ATP-binding protein (TIGR00968; EC 3.6.3.25; HMM-score: 103.3)
    D-methionine ABC transporter, ATP-binding protein (TIGR02314; EC 3.6.3.-; HMM-score: 102.8)
    thiol reductant ABC exporter, CydD subunit (TIGR02857; HMM-score: 102.7)
    Metabolism Transport and binding proteins Anions molybdate ABC transporter, ATP-binding protein (TIGR02142; EC 3.6.3.29; HMM-score: 98.1)
    Metabolism Transport and binding proteins Amino acids, peptides and amines glycine betaine/L-proline transport ATP binding subunit (TIGR01186; HMM-score: 97.4)
    Metabolism Transport and binding proteins Amino acids, peptides and amines putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein (TIGR03265; HMM-score: 97.3)
    Metabolism Transport and binding proteins Anions phosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 95.6)
    Metabolism Transport and binding proteins Amino acids, peptides and amines choline ABC transporter, ATP-binding protein (TIGR03415; HMM-score: 93.2)
    Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04520; EC 3.6.3.-; HMM-score: 91.6)
    Metabolism Transport and binding proteins Other thiamine ABC transporter, ATP-binding protein (TIGR01277; EC 3.6.3.-; HMM-score: 91.3)
    Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04521; EC 3.6.3.-; HMM-score: 91.1)
    Metabolism Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtE (TIGR03410; HMM-score: 88.8)
    2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT (TIGR03258; HMM-score: 87.9)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system (TIGR03864; HMM-score: 87.3)
    Metabolism Transport and binding proteins Cations and iron carrying compounds cobalt ABC transporter, ATP-binding protein (TIGR01166; HMM-score: 85.6)
    Metabolism Transport and binding proteins Amino acids, peptides and amines polyamine ABC transporter, ATP-binding protein (TIGR01187; EC 3.6.3.31; HMM-score: 85.4)
    thiol reductant ABC exporter, CydC subunit (TIGR02868; HMM-score: 77.4)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 77)
    Metabolism Transport and binding proteins Other LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 77)
    phosphonate C-P lyase system protein PhnL (TIGR02324; HMM-score: 76.4)
    Metabolism Transport and binding proteins Anions nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 76.1)
    Metabolism Transport and binding proteins Other nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 76.1)
    ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA (TIGR03005; HMM-score: 72.3)
    Metabolism Transport and binding proteins Other daunorubicin resistance ABC transporter, ATP-binding protein (TIGR01188; HMM-score: 71.9)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 71.8)
    Metabolism Transport and binding proteins Other heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 71.8)
    Metabolism Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtD (TIGR03411; HMM-score: 71.2)
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikD (TIGR02770; HMM-score: 70.6)
    Metabolism Transport and binding proteins Other pigment precursor permease (TIGR00955; HMM-score: 68.6)
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikE (TIGR02769; EC 3.6.3.24; HMM-score: 68.5)
    proposed F420-0 ABC transporter, ATP-binding protein (TIGR03873; HMM-score: 64.2)
    Metabolism Energy metabolism Methanogenesis methyl coenzyme M reductase system, component A2 (TIGR03269; HMM-score: 63)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 59.9)
    Metabolism Transport and binding proteins Other lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 59.9)
    lantibiotic protection ABC transporter, ATP-binding subunit (TIGR03740; HMM-score: 59.3)
    ABC transporter, permease/ATP-binding protein (TIGR02204; HMM-score: 58.6)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids D-xylose ABC transporter, ATP-binding protein (TIGR02633; EC 3.6.3.17; HMM-score: 57.7)
    Cellular processes Cellular processes Pathogenesis type I secretion system ATPase (TIGR03375; HMM-score: 52.6)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR03375; HMM-score: 52.6)
    Cellular processes Cellular processes Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 52)
    Metabolism Transport and binding proteins Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 52)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids glucan exporter ATP-binding protein (TIGR01192; EC 3.6.3.42; HMM-score: 51.4)
    Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 48.3)
    Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 48.3)
    Metabolism Transport and binding proteins Other antigen peptide transporter 2 (TIGR00958; HMM-score: 47.2)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01842; HMM-score: 47.2)
    Metabolism Transport and binding proteins Unknown substrate anchored repeat-type ABC transporter, ATP-binding subunit (TIGR03771; HMM-score: 46.3)
    ATP-binding cassette protein, ChvD family (TIGR03719; HMM-score: 46.2)
    Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 45.9)
    Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 45.9)
    gliding motility-associated ABC transporter ATP-binding subunit GldA (TIGR03522; HMM-score: 45.1)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01846; HMM-score: 43.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other FeS assembly ATPase SufC (TIGR01978; HMM-score: 42.5)
    Metabolism Central intermediary metabolism Phosphorus compounds phosphonate C-P lyase system protein PhnK (TIGR02323; HMM-score: 42.5)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking ABC-type bacteriocin transporter (TIGR01193; HMM-score: 42.2)
    Genetic information processing Protein fate Protein modification and repair ABC-type bacteriocin transporter (TIGR01193; HMM-score: 42.2)
    Metabolism Transport and binding proteins Other ABC-type bacteriocin transporter (TIGR01193; HMM-score: 42.2)
    Metabolism Transport and binding proteins Other rim ABC transporter (TIGR01257; HMM-score: 36.1)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit A (TIGR00630; EC 3.1.25.-; HMM-score: 33.9)
    Metabolism Transport and binding proteins Amino acids, peptides and amines cyclic peptide transporter (TIGR01194; HMM-score: 23.4)
    Metabolism Transport and binding proteins Other cyclic peptide transporter (TIGR01194; HMM-score: 23.4)
    acidobacterial duplicated orphan permease (TIGR03434; HMM-score: 22.5)
    Metabolism Transport and binding proteins Other pleiotropic drug resistance family protein (TIGR00956; HMM-score: 22.2)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking lipoprotein releasing system, transmembrane protein, LolC/E family (TIGR02212; HMM-score: 18.4)
    Genetic information processing Protein synthesis Translation factors ribosome small subunit-dependent GTPase A (TIGR00157; EC 3.6.-.-; HMM-score: 15.9)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair exonuclease SbcC (TIGR00618; HMM-score: 15.4)
    rad50 (TIGR00606; HMM-score: 11.5)
  • TheSEED:
  • PFAM:
    P-loop_NTPase (CL0023) ABC_tran; ABC transporter (PF00005; HMM-score: 79.7)
    and 10 more
    BPD_transp_1 (CL0404) FtsX; FtsX-like permease family (PF02687; HMM-score: 28.1)
    P-loop_NTPase (CL0023) ATPase_2; ATPase domain predominantly from Archaea (PF01637; HMM-score: 22.8)
    SMC_N; RecF/RecN/SMC N terminal domain (PF02463; HMM-score: 21.4)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 19.7)
    AAA_21; AAA domain, putative AbiEii toxin, Type IV TA system (PF13304; HMM-score: 16.8)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 16.4)
    AAA_24; AAA domain (PF13479; HMM-score: 14.1)
    MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 12.8)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 11.9)
    AAA_22; AAA domain (PF13401; HMM-score: 10.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 4
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0003
    • Cytoplasmic Membrane Score: 0.986
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0135
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006846
    • TAT(Tat/SPI): 0.002327
    • LIPO(Sec/SPII): 0.000568
  • predicted transmembrane helices (TMHMM): 4

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000461695 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MFEIRNLSLSFAGRRLLEPTDLIFERGKVYTIYGKSGVGKSSLLNKIGLLSATDPSVSYFFDGKEIDIENKKSVSVFIAEEVAFVFQGRNLINDLTVFENLRLALNFYDLSPDEIESKIDTVLADLQISSLKHAYPEDLSGGEEQRVAIARALVTGKTLILADEPTSSLDKENREKVSALLIDLAHKYHKIVLIVSHDEAMIAIGDVQLHFKDHKLVGNCLILNSDEGIKDSKKWSSCLSSSHTKLSVLKHRRPFLPRLLAFFISLVVAIAVTSINFQSLFADKYHQLVNNSLENGFLVINDSLHLQTTKVLDDFLSFDKEEITSISTSQNIQTVNPYIEFLSLGMTFDNSKDYSQLQKNFQPTLTIDGQTRSLTRNFSIQPLYQTNTTQRQIEYFDRSNEKGIYLSEQFISDEKLPNIVSGTTVTLTFYIPISLYESSIEKEGNILKGDGDLFVKVDKTYPVLGIVKKSYPFEYSPYGNTLFMNIAEMEELQNEAIQQHPMTKMALDGFPLKSWMPSAIHVLLKDSGAIPEELSRIRAISSQITILSSYENYEEFNKGLTYIRQFLMLLSLVLLILVIAVLSFVFFLLNRPRRFEVGILKSLGYSTQNIVWLFLKELIGYGKTISILASCLLVILSILAMQVLKLEISDVFKFYLTSVFTLIGLSVSVLIISGLLPIYTTCRQTVVDTIRKNG

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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