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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 22-FEB-2023

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_RS04245 [old locus tag: SPAP_0855 ]
  • pan locus tag?: PNEUPAN001837000
  • symbol: SPAP_RS04245
  • pan gene symbol?: —
  • synonym:
  • product: ATP-binding cassette domain-containing protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_RS04245 [old locus tag: SPAP_0855 ]
  • symbol: SPAP_RS04245
  • product: ATP-binding cassette domain-containing protein
  • replicon: chromosome
  • strand: +
  • coordinates: 810027..811838
  • length: 1812
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014494 (810027..811838) NCBI
  • BioCyc: SPAP_RS04245 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    ATAAATGATTTGACCGTATTTGAAAATTTAAGACTAGCTTTAAACTTTTATGACTTGAGT
    CCAGATGAAATAGAAAGCAAAATTGATACAGTATTGGCGGATTTACAGATTTCTTCTTTA
    AAGCATGCTTATCCAGAAGATTTATCCGGTGGTGAAGAACAACGAGTGGCAATCGCAAGA
    GCCTTAGTTACAGGAAAGACTCTCATCTTAGCTGATGAACCAACAAGTTCTTTGGATAAA
    GAAAATAGAGAAAAAATCTCCGCCTTGTTAATTGATTTAGCTCACAAATATCATAAAATT
    GTATTGATTGTTTCGCATGATGAGGCGATGATTGCAATAGGAGATGTTCAGCTTCATTTT
    AAAGACCATAAATTAGTTGGGAATTGTCTTATTTTGAATTCTGATGAAGGGATAAAGGAT
    TCTAAGAAGTGGTCCTCCTGTTTGTCGTCTTCTCATACGAAGCTATCCGTTTTGAAACAT
    AGAAGGCCTTTTTTACCTAGATTATTAGCGTTTTTTATCTCTCTTGTAGTTGCTATAGCA
    GTAACCTCTATTAACTTTCAGTCCTTATTTGCAGATAAGTATCACCAACTGGTGAACAAC
    TCACTCGAAAATGGCTTCTTGGTGATTAATGATTCGCTTCATTTACAAACTACAAAAGTG
    TTGGATGATTTTCTCAGTTTTGATAAGGAGGAAATCACCTCAATTAGCACAAGTCAGAAT
    ATTCAAACCGTCAATCCTTATATAGAGTTTCTCTCTTTGGGTATGACGTTTGATAATTCA
    AAAGACTATTCACAACTTCAAAAGAACTTTCAGCCAACTTTGACTATTGATGGTCAGACC
    AGAAGCTTGACAAGAAATTTTTCAATTCAACCCTTGTATCAGACAAATACAACACAGAGG
    CAGATAGAGTATTTTGATAGGAGCAATGAAAAAGGGATTTATCTATCTGAGCAATTCATT
    TCAGATGAAAAATTACCAAATATAGTTTCGGGAACTACCGTGACACTGACTTTTTATATT
    CCAATTTCTTTATATGAATCAAGTATAGAGAAAGAGGGGAATATATTGAAAGGAGATGGC
    GGTTTATTTGTCAAAGTGGATAAAACATATCCTGTTTTAGGGATTGTTAAAAAAAGTTAT
    CCGTTTGAATATTCCCCTTATGGGAACACCCTATTTATGAATATTGCTGAAATGGAAGAA
    TTGCAAAATGAAGCAATTCAACAGCATCCCATGACGAAGATGGCTTTAGATGGTTTTCCT
    TTGAAATCATGGATGCCGAGTGCGATTCATGTGTTACTAAAGGATAGCGGTGCTATTCCT
    GAAGAATTGAGTAGAATAAGAGCAATCTCTTCACAAATTACTATTTTATCATCATATGAA
    AACTACGAAGAATTTAATAAAGGACTCACCTATATCAGGCAATTTTTAATGTTGCTATCC
    CTAGTCTTACTCATCCTTGTCATCGCAGTATTGTCCTTTGTTTTCTTTTTGCTCAATCGT
    CCTCGACGCTTTGAAGTAGGGATTTTAAAATCTTTGGGATACAGTACTCAAAATATTGTT
    TGGCTTTTCTTAAAAGAATTAATTGGTTATGGTAAAACAATTTCGATATTAGCAAGTTGT
    TTACTCGTCATTCTTTCCATTTTAGCAATGCAAGTGCTTAAATTGGAAATTTCAGATGTT
    TTTAAATTCTATCTAACTTCCGTTTTCACCTTAATTGGATTATCAGTCTCAGTACTGATA
    ATAAGTGGCTTACTACCTATATACACAACTTGTAGGCAAACAGTTGTCGATACTATCCGA
    AAGAATGGATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1812

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_RS04245 [old locus tag: SPAP_0855 ]
  • symbol: SPAP_RS04245
  • description: ATP-binding cassette domain-containing protein
  • length: 603
  • theoretical pI: 6.11423
  • theoretical MW: 68119.3
  • GRAVY: 0.113433

⊟Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes Toxin production and resistance putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 95.8)
    Metabolism Transport and binding proteins Unknown substrate putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 95.8)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking lipoprotein releasing system, ATP-binding protein (TIGR02211; EC 3.6.3.-; HMM-score: 90.5)
    ABC exporter ATP-binding subunit, DevA family (TIGR02982; HMM-score: 88.5)
    Cellular processes Cellular processes Cell division cell division ATP-binding protein FtsE (TIGR02673; HMM-score: 87.2)
    and 65 more
    Metabolism Transport and binding proteins Amino acids, peptides and amines putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein (TIGR03265; HMM-score: 70.9)
    D-methionine ABC transporter, ATP-binding protein (TIGR02314; EC 3.6.3.-; HMM-score: 69.1)
    Metabolism Transport and binding proteins Amino acids, peptides and amines polyamine ABC transporter, ATP-binding protein (TIGR01187; EC 3.6.3.31; HMM-score: 68)
    Metabolism Transport and binding proteins Anions sulfate ABC transporter, ATP-binding protein (TIGR00968; EC 3.6.3.25; HMM-score: 67.6)
    Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04520; EC 3.6.3.-; HMM-score: 67.4)
    Metabolism Transport and binding proteins Anions molybdate ABC transporter, ATP-binding protein (TIGR02142; EC 3.6.3.29; HMM-score: 67.3)
    Metabolism Transport and binding proteins Amino acids, peptides and amines glycine betaine/L-proline transport ATP binding subunit (TIGR01186; HMM-score: 66.4)
    Metabolism Transport and binding proteins Amino acids, peptides and amines choline ABC transporter, ATP-binding protein (TIGR03415; HMM-score: 63.1)
    Metabolism Transport and binding proteins Anions phosphonate ABC transporter, ATP-binding protein (TIGR02315; EC 3.6.3.28; HMM-score: 62.2)
    Metabolism Transport and binding proteins Other thiamine ABC transporter, ATP-binding protein (TIGR01277; EC 3.6.3.-; HMM-score: 61.8)
    thiol reductant ABC exporter, CydD subunit (TIGR02857; HMM-score: 61.2)
    Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04521; EC 3.6.3.-; HMM-score: 59.2)
    2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT (TIGR03258; HMM-score: 59)
    Metabolism Transport and binding proteins Cations and iron carrying compounds cobalt ABC transporter, ATP-binding protein (TIGR01166; HMM-score: 56.8)
    Metabolism Transport and binding proteins Other daunorubicin resistance ABC transporter, ATP-binding protein (TIGR01188; HMM-score: 56.7)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 55.7)
    Metabolism Transport and binding proteins Other LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 55.7)
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikD (TIGR02770; HMM-score: 55)
    Metabolism Transport and binding proteins Anions phosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 54.7)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system (TIGR03864; HMM-score: 54.1)
    phosphonate C-P lyase system protein PhnL (TIGR02324; HMM-score: 53)
    ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA (TIGR03005; HMM-score: 50.8)
    thiol reductant ABC exporter, CydC subunit (TIGR02868; HMM-score: 50)
    Metabolism Transport and binding proteins Anions nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 49.9)
    Metabolism Transport and binding proteins Other nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 49.9)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 48.4)
    Metabolism Transport and binding proteins Other heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 48.4)
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikE (TIGR02769; EC 3.6.3.24; HMM-score: 47.5)
    Metabolism Transport and binding proteins Unknown substrate anchored repeat-type ABC transporter, ATP-binding subunit (TIGR03771; HMM-score: 44.9)
    Cellular processes Cellular processes Pathogenesis type I secretion system ATPase (TIGR03375; HMM-score: 44.3)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR03375; HMM-score: 44.3)
    Metabolism Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtE (TIGR03410; HMM-score: 43.7)
    proposed F420-0 ABC transporter, ATP-binding protein (TIGR03873; HMM-score: 42.9)
    Metabolism Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtD (TIGR03411; HMM-score: 40.7)
    ABC transporter, permease/ATP-binding protein (TIGR02204; HMM-score: 40.1)
    Metabolism Energy metabolism Methanogenesis methyl coenzyme M reductase system, component A2 (TIGR03269; HMM-score: 39.9)
    Metabolism Transport and binding proteins Other pigment precursor permease (TIGR00955; HMM-score: 37.8)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01842; HMM-score: 37.6)
    Cellular processes Cellular processes Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 37.3)
    Metabolism Transport and binding proteins Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 37.3)
    ATP-binding cassette protein, ChvD family (TIGR03719; HMM-score: 37)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 34.9)
    Metabolism Transport and binding proteins Other lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 34.9)
    Metabolism Transport and binding proteins Other antigen peptide transporter 2 (TIGR00958; HMM-score: 34.6)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01846; HMM-score: 32.5)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking ABC-type bacteriocin transporter (TIGR01193; HMM-score: 31.5)
    Genetic information processing Protein fate Protein modification and repair ABC-type bacteriocin transporter (TIGR01193; HMM-score: 31.5)
    Metabolism Transport and binding proteins Other ABC-type bacteriocin transporter (TIGR01193; HMM-score: 31.5)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids D-xylose ABC transporter, ATP-binding protein (TIGR02633; EC 3.6.3.17; HMM-score: 31.5)
    gliding motility-associated ABC transporter ATP-binding subunit GldA (TIGR03522; HMM-score: 31.5)
    Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 31.4)
    Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 31.4)
    lantibiotic protection ABC transporter, ATP-binding subunit (TIGR03740; HMM-score: 30.3)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids glucan exporter ATP-binding protein (TIGR01192; EC 3.6.3.42; HMM-score: 30.1)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit A (TIGR00630; EC 3.1.25.-; HMM-score: 29.7)
    Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 28.1)
    Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 28.1)
    Metabolism Central intermediary metabolism Phosphorus compounds phosphonate C-P lyase system protein PhnK (TIGR02323; HMM-score: 26.3)
    acidobacterial duplicated orphan permease (TIGR03434; HMM-score: 22.8)
    Metabolism Transport and binding proteins Other rim ABC transporter (TIGR01257; HMM-score: 22.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other FeS assembly ATPase SufC (TIGR01978; HMM-score: 21.1)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking lipoprotein releasing system, transmembrane protein, LolC/E family (TIGR02212; HMM-score: 18.7)
    Metabolism Transport and binding proteins Amino acids, peptides and amines cyclic peptide transporter (TIGR01194; HMM-score: 15.5)
    Metabolism Transport and binding proteins Other cyclic peptide transporter (TIGR01194; HMM-score: 15.5)
    rad50 (TIGR00606; HMM-score: 12.1)
  • TheSEED: see SPAP_0855
  • PFAM:
    P-loop_NTPase (CL0023) ABC_tran; ABC transporter (PF00005; HMM-score: 42)
    and 2 more
    BPD_transp_1 (CL0404) FtsX; FtsX-like permease family (PF02687; HMM-score: 28.4)
    P-loop_NTPase (CL0023) SMC_N; RecF/RecN/SMC N terminal domain (PF02463; HMM-score: 17.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 4
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0005
    • Cytoplasmic Membrane Score: 0.9778
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0216
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004972
    • TAT(Tat/SPI): 0.000154
    • LIPO(Sec/SPII): 0.00025
  • predicted transmembrane helices (TMHMM): 4

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_274378598 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNDLTVFENLRLALNFYDLSPDEIESKIDTVLADLQISSLKHAYPEDLSGGEEQRVAIARALVTGKTLILADEPTSSLDKENREKISALLIDLAHKYHKIVLIVSHDEAMIAIGDVQLHFKDHKLVGNCLILNSDEGIKDSKKWSSCLSSSHTKLSVLKHRRPFLPRLLAFFISLVVAIAVTSINFQSLFADKYHQLVNNSLENGFLVINDSLHLQTTKVLDDFLSFDKEEITSISTSQNIQTVNPYIEFLSLGMTFDNSKDYSQLQKNFQPTLTIDGQTRSLTRNFSIQPLYQTNTTQRQIEYFDRSNEKGIYLSEQFISDEKLPNIVSGTTVTLTFYIPISLYESSIEKEGNILKGDGGLFVKVDKTYPVLGIVKKSYPFEYSPYGNTLFMNIAEMEELQNEAIQQHPMTKMALDGFPLKSWMPSAIHVLLKDSGAIPEELSRIRAISSQITILSSYENYEEFNKGLTYIRQFLMLLSLVLLILVIAVLSFVFFLLNRPRRFEVGILKSLGYSTQNIVWLFLKELIGYGKTISILASCLLVILSILAMQVLKLEISDVFKFYLTSVFTLIGLSVSVLIISGLLPIYTTCRQTVVDTIRKNG

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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