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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 09-FEB-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 6A-10
  • locus tag: HKM25_RS05825 [old locus tag: HKM25_1191 ]
  • pan locus tag?: PNEUPAN002518000
  • symbol: HKM25_RS05825
  • pan gene symbol?: glnHP5
  • synonym:
  • product: ABC transporter substrate-binding protein/permease

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HKM25_RS05825 [old locus tag: HKM25_1191 ]
  • symbol: HKM25_RS05825
  • product: ABC transporter substrate-binding protein/permease
  • replicon: chromosome
  • strand: +
  • coordinates: 1164599..1166764
  • length: 2166
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP053210 (1164599..1166764) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1098 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    ATGAAGAAAAAATTTCTAGCATTTTTGCTAATTTTATTCCCAATTTTCTCACTAGGTATT
    GCCAAAGCAGAAACGATTAAGATTGTTTCTGATACCGCCTATGCACCTTTTGAGTTTAAA
    GATTCAGATCAAACTTATAAAGGAATTGATGTTGACATTATTAACAAAGTCGCTGAGATT
    AAAGGCTGGAACATTCAGATGTCCTATCCTGGATTTGACGCAGCAGTCAATGCGGTTCAA
    GCTGGGCAAGCCGACGCTATCATGGCAGGGATGACAAAGACTAAAGAACGTGAAAAAGTC
    TTCACCATGTCTGATACTTACTATGATACAAAAGTTGTCATTGCTACTACAAAGTCACAC
    AAAATTAGCAAGTACGACCAATTAACTGGCAAAACCGTTGGTGTTAAAAACGGAACTGCC
    GCTCAACGTTTCCTTGAAACAATCAAAGATAAATACGGCTTTACTATTAAAACATTTGAC
    ACTGGTGATTTAATGAACAACAGCTTGAGTGCTGGTGCCATCGATGCCATGATGGATGAC
    AAACCTGTTATCGAATATGCCATTAACCAAGGTCAAGATCTCCATATTGAAATGGATGGT
    GAAGCTGTAGGAAGTTTTGCTTTCGGTGTGAAAAAAGGAAGTAAATACGAGCACCTGGTT
    ACTGAATTTAACCAAGCCTTGGCTGAAATGAAAAAAGATGGTAGTCTTGATAAAATTATC
    AAGAAATGGACTGCTTCATCATCTTCAGCAGTGCCAACTACAACTACTCTCGCAGGATTA
    AAAGCTATTCCTGTTAAGGCTAAATATATCATTGCCAGCGATTCTTCTTTTGCACCTTTT
    GTTTTCCAAAATTCAAGCAACCAATACACTGGTATTGATATGGAATTGATTAAGGCAATC
    GCTAAAGACCAAGGTTTTGAAATTGAAATCACCAACCCTGGTTTTGATGCTGCTATCAGT
    GCTGTCCAAGCTGGTCAAGCCGATGGTATCATTGCTGGGATGTCTGTCACAGATGCTCGT
    AAGGCAACTTTTGACTTCTCAGAATCATACTACACTGCTAATACCATTCTTGGTGTCAAA
    GAATCAAGCAATATTGCTTCTTATGAAGATCTAAAAGGAAAGACAGTCGGTGTTAAAAAC
    GGAACTGCTTCTCAAACCTTCCTAACAGAAAATCAAAGCAAATACGGTTACAAAATCAAA
    ACCTTTGCTGATGGTTCTTCAATGTATGACAGTTTAAACACTGGTGCCATTGATGCCGTT
    ATGGATGATGAACCTGTTCTCAAATATTCTATCAGCCAAGGTCAAAAATTGAAAACTCCA
    ATCTCTGGAACTCCAATCGGTGAAACAGCCTTTGCCGTTAAAAAAGGAGCAAATCCAGAA
    CTGATTGAAATGTTCAACAACGGACTTGCAAACCTTAAAGCAAACGGTGAATTCCAAAAG
    ATTCTTGACAAATACCTAGCTAGCGAATCTTCAACTGCTTCAACAAGTACTGTTGACGAA
    ACAACGCTCTGGGGCTTGCTTCAAAACAACTACAAACAACTCCTTAGCGGTCTTGGTATC
    ACTCTTGCTCTAGCTCTTATCTCATTTGCTATTGCCATTGTCATCGGAATTATCTTCGGT
    ATGTTTAGCGTTAGCCCATACAAATCTCTTCGCGTCATCTCTGAGATTTTCGTTGACGTT
    ATTCGTGGTATTCCATTGATGATTCTTGCAGCCTTCATCTTCTGGGGAATTCCAAACTTC
    ATCGAGTCTATCACAGGCCAACAAAGCCCAATTAACGACTTTGTAGCTGGAACCATTGCC
    CTCTCACTCAATGCGGCTGCTTATATCGCTGAAATCGTTCGTGGTGGTATTCAGGCCGTT
    CCAGTTGGCCAAATGGAAGCCAGCCGAAGCTTGGGTATCTCTTATGGAAAAACCATGCGT
    AAGATTATCTTGCCACAAGCAACTAAATTGATGTTGCCAAACTTTGTCAACCAATTCGTT
    ATCGCTCTTAAAGATACAACTATCGTATCTGCTATCGGTCTTGTTGAACTCTTCCAAACT
    GGTAAGATTATCATTGCTCGTAACTACCAAAGTTTCAAGATGTATGCAATCCTTGCTATC
    TTCTATCTTGTAATTATCACACTTTTGACTAGACTAGCGAAACGCTTAGAAAAGAGGATT
    AGTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2166

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HKM25_RS05825 [old locus tag: HKM25_1191 ]
  • symbol: HKM25_RS05825
  • description: ABC transporter substrate-binding protein/permease
  • length: 721
  • theoretical pI: 8.90744
  • theoretical MW: 78301.9
  • GRAVY: 0.108877

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Amino acids, peptides and amines lysine-arginine-ornithine-binding periplasmic protein (TIGR01096; HMM-score: 284.7)
    and 14 more
    ectoine/hydroxyectoine ABC transporter, permease protein EhuD (TIGR03003; HMM-score: 126.4)
    ectoine/hydroxyectoine ABC transporter, permease protein EhuC (TIGR03004; HMM-score: 116.8)
    Metabolism Transport and binding proteins Amino acids, peptides and amines amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family (TIGR01726; HMM-score: 74.9)
    Metabolism Transport and binding proteins Amino acids, peptides and amines ectoine/hydroxyectoine ABC transporter solute-binding protein EhuB (TIGR02995; HMM-score: 72.7)
    extracellular substrate-binding orphan protein, GRRM family (TIGR04262; HMM-score: 65.2)
    Metabolism Transport and binding proteins Other ABC transporter, substrate-binding protein, aliphatic sulfonates family (TIGR01728; HMM-score: 45.6)
    Metabolism Transport and binding proteins Anions phosphonate ABC transporter, permease protein PhnE (TIGR01097; HMM-score: 40.1)
    Metabolism Transport and binding proteins Anions phosphate ABC transporter, permease protein PstA (TIGR00974; HMM-score: 28.9)
    Metabolism Transport and binding proteins Anions phosphate ABC transporter, permease protein PstC (TIGR02138; HMM-score: 23)
    Metabolism Transport and binding proteins Unknown substrate TRAP transporter solute receptor, TAXI family (TIGR02122; HMM-score: 20.7)
    quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein (TIGR03871; HMM-score: 18.3)
    NifC-like ABC-type porter (TIGR01581; HMM-score: 17.4)
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel ABC transporter, permease subunit NikB (TIGR02789; EC 3.6.3.24; HMM-score: 16.8)
    Metabolism Transport and binding proteins Anions molybdate ABC transporter, permease protein (TIGR02141; HMM-score: 10)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    PBP (CL0177) SBP_bac_3; Bacterial extracellular solute-binding proteins, family 3 (PF00497; HMM-score: 367.8)
    and 5 more
    BPD_transp_1 (CL0404) BPD_transp_1; Binding-protein-dependent transport system inner membrane component (PF00528; HMM-score: 88.7)
    PBP (CL0177) Lig_chan-Glu_bd; Ligated ion channel L-glutamate- and glycine-binding site (PF10613; HMM-score: 40.1)
    NMT1; NMT1/THI5 like (PF09084; HMM-score: 38.4)
    Phosphonate-bd; ABC transporter, phosphonate, periplasmic substrate-binding protein (PF12974; HMM-score: 21.1)
    no clan defined Tim17; Tim17/Tim22/Tim23/Pmp24 family (PF02466; HMM-score: 16.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 4
  • SignalP: Signal peptide SP(Sec/SPI) length 23 aa
    • SP(Sec/SPI): 0.993929
    • TAT(Tat/SPI): 0.000301
    • LIPO(Sec/SPII): 0.004761
    • Cleavage Site: CS pos: 23-24. AKA-ET. Pr: 0.9521
  • predicted transmembrane helices (TMHMM): 4

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000726259 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKKKFLAFLLILFPIFSLGIAKAETIKIVSDTAYAPFEFKDSDQTYKGIDVDIINKVAEIKGWNIQMSYPGFDAAVNAVQAGQADAIMAGMTKTKEREKVFTMSDTYYDTKVVIATTKSHKISKYDQLTGKTVGVKNGTAAQRFLETIKDKYGFTIKTFDTGDLMNNSLSAGAIDAMMDDKPVIEYAINQGQDLHIEMDGEAVGSFAFGVKKGSKYEHLVTEFNQALAEMKKDGSLDKIIKKWTASSSSAVPTTTTLAGLKAIPVKAKYIIASDSSFAPFVFQNSSNQYTGIDMELIKAIAKDQGFEIEITNPGFDAAISAVQAGQADGIIAGMSVTDARKATFDFSESYYTANTILGVKESSNIASYEDLKGKTVGVKNGTASQTFLTENQSKYGYKIKTFADGSSMYDSLNTGAIDAVMDDEPVLKYSISQGQKLKTPISGTPIGETAFAVKKGANPELIEMFNNGLANLKANGEFQKILDKYLASESSTASTSTVDETTLWGLLQNNYKQLLSGLGITLALALISFAIAIVIGIIFGMFSVSPYKSLRVISEIFVDVIRGIPLMILAAFIFWGIPNFIESITGQQSPINDFVAGTIALSLNAAAYIAEIVRGGIQAVPVGQMEASRSLGISYGKTMRKIILPQATKLMLPNFVNQFVIALKDTTIVSAIGLVELFQTGKIIIARNYQSFKMYAILAIFYLVIITLLTRLAKRLEKRIS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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