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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 6A-10
  • locus tag: HKM25_RS06055 [old locus tag: HKM25_1242 ]
  • pan locus tag?: PNEUPAN002570000
  • symbol: HKM25_RS06055
  • pan gene symbol?: —
  • synonym:
  • product: HD domain-containing protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HKM25_RS06055 [old locus tag: HKM25_1242 ]
  • symbol: HKM25_RS06055
  • product: HD domain-containing protein
  • replicon: chromosome
  • strand: +
  • coordinates: 1216175..1217479
  • length: 1305
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP053210 (1216175..1217479) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1145 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGAACGAAAAAGTATTCCGTGACCCTGTTCACAACTACATCCATGTCAATAATCAAATC
    ATCTATGACTTGATTAATACAAAAGAATTTCAGCGTTTGCGCCGGATCAAACAACTGGGA
    ACTTCCAGTTATACCTTCCACGGTGGAGAACACAGTCGCTTCTCTCACTGTCTAGGAGTC
    TATGAAATTGCACGACGCATCACAGAGATTTTCGAAGAAAAATATCCTGAGGAATGGAAT
    CCTGCCGAGTCTCTCTTGACCATGACCGCTGCTCTCCTACACGACCTTGGGCATGGTGCC
    TACTCCCATACTTTTGAAAATCTCTTTGATACAGACCATGAAGCCATTACTCAGGAGATT
    ATTCAAAATCCTGAGACAGAGATTCACCAAGTCCTGCTACAAGTGGCACCTGATTTCCCA
    GAAAAGGTGGCCAGTGTCATTGACCATACCTATCCTAATAAGCAGGTCGTGCAGCTCATT
    TCTAGTCAGATTGACGCAGATCGCATGGACTATCTCTTGCGCGACTCCTATTTTACAGGA
    GCATCCTATGGGGAATTTGACCTGACTCGAATCCTCCGAGTCATTCGTCCTATCGAAAAT
    GGTATCGCCTTTCAGCGCAATGGCATGCACGCCATCGAAGACTACGTCCTCAGTCGCTAC
    CAGATGTACATGCAGGTTTATTTCCACCCCGCAACACGCGCCATGGAAGTTCTCCTACAG
    AATCTTCTCAAACGCGCCAAGGAACTCTATCCTGAGGACAAGGATTTCTTTGCCCGAACT
    TCTCCACACCTCCTGCCTTTCTTCGAAAAAAATGTGACCTTGACTGACTATCTGGCTCTG
    GATGATGGCGTGATGAATACCTACTTCCAGCTTTGGATGACCAGTCCTGACAAGATTCTT
    GCAGATTTATCGCATCGCTTTGTCAACCGCAAGGTCTTTAAATCCATTACCTTTTCACAA
    GAGGACCAAGATCAACTTACTAGCATGAGAAAATTGGTTGAGGATATCGGCTTTGATCCC
    GACTACTACACTGCCATTCATAAGAACTTTGACCTCCCTTATGATATCTATCGTCCCGAA
    TCTGAAAACCCACGGACACAGATTGAGATTTTACAAAAAAATGGAGAACTGGCCGAACTC
    TCTAGCCTGTCTCCTATCGTCCAATCCCTTGCTGGCAGTCGCCACGGAGATAATCGCTTT
    TATTTTCCAAAAGAAATGTTGGACCAAAACAGCATCTTTGCAAGCATTACCCAGCAATTT
    TTACACTTGATTGAGAACGATCATTTTACCCCAAATAAAAACTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1305

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HKM25_RS06055 [old locus tag: HKM25_1242 ]
  • symbol: HKM25_RS06055
  • description: HD domain-containing protein
  • length: 434
  • theoretical pI: 5.40741
  • theoretical MW: 50841.9
  • GRAVY: -0.473502

⊟Function[edit | edit source]

  • reaction:
    EC 3.1.-.-?  ExPASy
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions putative dGTPase (TIGR01353; EC 3.1.5.1; HMM-score: 27.1)
    and 4 more
    HDIG domain (TIGR00277; HMM-score: 17.8)
    CRISPR-associated endonuclease Cas3-HD (TIGR01596; EC 3.1.-.-; HMM-score: 12.9)
    phosphonate degradation operons associated HDIG domain protein (TIGR03276; HMM-score: 11.5)
    CRISPR-associated helicase Cas3, subtype I-F/YPEST (TIGR02562; HMM-score: 11.1)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    HD_PDEase (CL0237) HD; HD domain (PF01966; HMM-score: 52.6)
    and 2 more
    no clan defined HD_assoc_2; HD associated region (PF19276; HMM-score: 40.2)
    HD_PDEase (CL0237) PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase (PF00233; HMM-score: 15.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9586
    • Cytoplasmic Membrane Score: 0.0367
    • Cell wall & surface Score: 0.0006
    • Extracellular Score: 0.0041
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.010057
    • TAT(Tat/SPI): 0.000943
    • LIPO(Sec/SPII): 0.000369
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001003499 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNEKVFRDPVHNYIHVNNQIIYDLINTKEFQRLRRIKQLGTSSYTFHGGEHSRFSHCLGVYEIARRITEIFEEKYPEEWNPAESLLTMTAALLHDLGHGAYSHTFENLFDTDHEAITQEIIQNPETEIHQVLLQVAPDFPEKVASVIDHTYPNKQVVQLISSQIDADRMDYLLRDSYFTGASYGEFDLTRILRVIRPIENGIAFQRNGMHAIEDYVLSRYQMYMQVYFHPATRAMEVLLQNLLKRAKELYPEDKDFFARTSPHLLPFFEKNVTLTDYLALDDGVMNTYFQLWMTSPDKILADLSHRFVNRKVFKSITFSQEDQDQLTSMRKLVEDIGFDPDYYTAIHKNFDLPYDIYRPESENPRTQIEILQKNGELAELSSLSPIVQSLAGSRHGDNRFYFPKEMLDQNSIFASITQQFLHLIENDHFTPNKN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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