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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 6A-10
  • locus tag: HKM25_RS06550 [old locus tag: HKM25_1344 ]
  • pan locus tag?: PNEUPAN002684000
  • symbol: hemW
  • pan gene symbol?: hemN
  • synonym:
  • product: radical SAM family heme chaperone HemW

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HKM25_RS06550 [old locus tag: HKM25_1344 ]
  • symbol: hemW
  • product: radical SAM family heme chaperone HemW
  • replicon: chromosome
  • strand: -
  • coordinates: 1309381..1310511
  • length: 1131
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP053210 (1309381..1310511) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1240 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    ATGCAGAAAAAACCAACGTCAGCCTATGTGCACATCCCATTTTGTACCCAGATTTGTTAT
    TATTGTGATTTTTCAAAGGTCTTCATCAAAAATCAGCCAGTCGACAGCTATTTAGAGCAT
    CTGCTGGAAGAGTTTCGTTCTTATGATATTGAAAAGTTGTCAACCCTTTATATCGGTGGT
    GGAACACCGACAGCCCTGTCGGCTCCGCAACTGGAGGTGTTACTGAATGGCTTGACTAAA
    AACTTGGATTTGTCTGTCTTGGAAGAGTTGACCATTGAAGCCAATCCAGGCGATTTGGAT
    GCGGATAAGATAGCTGTTTTGAAAAATTCGGCTGTCAATCGTGTTTCGCTAGGTGTCCAG
    ACCTTTGATGATAAGATGTTGAAAAAGATTGGGCGCAGTCATTTGGAGAAGGATATTTAT
    GAAAATATCGATCGCCTGAAACTGGCTGGTTTTGACAATATCTCCATTGATTTGATTTAT
    GCTCTGCCTGGTCAGACCATGGAGCAAGTAAAGGAAAATGTGGCTAAAGCCATTGGATTG
    GATATTCCCCACATGAGTTTGTATAGTTTGATTTTAGAAAACCATACGGTCTTTATGAAC
    CGGATGCGACGTGGGAAATTGCCTCTGCCTAAGGAGGAACTAGAAGCGGAGATGTTTGAG
    TACATCATTGCAGAGCTGGAGCGAGCGGGTTTTGAGCATTATGAGATTTCTAATTTCTCC
    AAACCCGGTTTTGAAAGTCGTCATAATCTCATGTACTGGGACAATGCTGAATACTATGGT
    ATTGGTGCAGGGGCATCTGGTTATGTCAATGGAGTACGCTATAAAAATCATGGTCCCATT
    CGTCATTATCTCAGTGCGGTTGAGGAAGGCAATGCTTGTATTACAGAAGATCACCTGAGT
    CAAAAGGAGCAAATGGAAGAAGAAATGTTCTTGGGACTCCGCAAGAAATCCGGGGTTTCC
    ATGGCGCGATTTGAGGAAAAATTTGGACAGTCTTTTGCTGGACTTTATGGAGAAATTGTC
    AGAGATTTGGTTCAACAAGGCCTCATGCAGATTGAGGGTGACCACGTTCGCATGACAAAG
    AGAGGTCTCTTTTTGGGAGATACTGTAGCAGAACGATTTATTTTGGAGTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1131

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HKM25_RS06550 [old locus tag: HKM25_1344 ]
  • symbol: HemW
  • description: radical SAM family heme chaperone HemW
  • length: 376
  • theoretical pI: 5.10946
  • theoretical MW: 42748.6
  • GRAVY: -0.292819

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin putative oxygen-independent coproporphyrinogen III oxidase (TIGR00539; EC 1.3.99.22; HMM-score: 379)
    and 16 more
    putative heme utilization radical SAM enzyme HutW (TIGR04107; HMM-score: 224.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin oxygen-independent coproporphyrinogen III oxidase (TIGR00538; EC 1.3.99.22; HMM-score: 185.4)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin coproporphyrinogen dehydrogenase HemZ (TIGR03994; EC 1.3.99.22; HMM-score: 173)
    HemN-related non-iron pseudo-SAM protein PsgB (TIGR04419; HMM-score: 114.5)
    Unknown function Enzymes of unknown specificity radical SAM protein, TIGR01212 family (TIGR01212; HMM-score: 38.7)
    Unknown function Enzymes of unknown specificity B12-binding domain/radical SAM domain protein, MJ_1487 family (TIGR04013; HMM-score: 37.1)
    Genetic information processing Transcription DNA-dependent RNA polymerase radical SAM enzyme/protein acetyltransferase, ELP3 family (TIGR01211; EC 2.3.1.48; HMM-score: 25.8)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Molybdopterin molybdenum cofactor biosynthesis protein A (TIGR02666; HMM-score: 23.9)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA-i(6)A37 thiotransferase enzyme MiaB (TIGR01574; EC 2.-.-.-; HMM-score: 22.8)
    Genetic information processing Protein synthesis tRNA and rRNA base modification MiaB-like tRNA modifying enzyme (TIGR01579; HMM-score: 21.6)
    radical SAM methylthiotransferase, MiaB/RimO family (TIGR00089; EC 2.1.1.-,2.8.1.-; HMM-score: 20.6)
    Cellular processes Cellular processes Toxin production and resistance radical SAM P-methyltransferase, PhpK family (TIGR04479; EC 2.1.-.-; HMM-score: 17.5)
    Unknown function Enzymes of unknown specificity B12-binding domain/radical SAM domain protein, MJ_0865 family (TIGR04014; HMM-score: 13.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Molybdopterin probable molybdenum cofactor biosynthesis protein A (TIGR02668; HMM-score: 13.4)
    Genetic information processing Protein fate Protein modification and repair anaerobic ribonucleoside-triphosphate reductase activating protein (TIGR02495; EC 1.97.-.-; HMM-score: 12.9)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides 2'-Deoxyribonucleotide metabolism anaerobic ribonucleoside-triphosphate reductase activating protein (TIGR02495; EC 1.97.-.-; HMM-score: 12.9)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    TIM_barrel (CL0036) Radical_SAM; Radical SAM superfamily (PF04055; HMM-score: 79.7)
    HTH (CL0123) HemN_C; HemN C-terminal domain (PF06969; HMM-score: 72.7)
    and 1 more
    TPR (CL0020) TAF6_C; TAF6 C-terminal HEAT repeat domain (PF07571; HMM-score: 12.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9984
    • Cytoplasmic Membrane Score: 0.0002
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0013
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.019578
    • TAT(Tat/SPI): 0.000422
    • LIPO(Sec/SPII): 0.020209
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001170072 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MQKKPTSAYVHIPFCTQICYYCDFSKVFIKNQPVDSYLEHLLEEFRSYDIEKLSTLYIGGGTPTALSAPQLEVLLNGLTKNLDLSVLEELTIEANPGDLDADKIAVLKNSAVNRVSLGVQTFDDKMLKKIGRSHLEKDIYENIDRLKLAGFDNISIDLIYALPGQTMEQVKENVAKAIGLDIPHMSLYSLILENHTVFMNRMRRGKLPLPKEELEAEMFEYIIAELERAGFEHYEISNFSKPGFESRHNLMYWDNAEYYGIGAGASGYVNGVRYKNHGPIRHYLSAVEEGNACITEDHLSQKEQMEEEMFLGLRKKSGVSMARFEEKFGQSFAGLYGEIVRDLVQQGLMQIEGDHVRMTKRGLFLGDTVAERFILE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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