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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 28-AUG-2013
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae TCH8431/19A
- locus tag: HMPREF0837_10027 [new locus tag: HMPREF0837_RS00160 ]
- pan locus tag?: PNEUPAN003625000
- symbol: HMPREF0837_10027
- pan gene symbol?: ulaR
- synonym:
- product: PRD domain protein
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: HMPREF0837_10027 [new locus tag: HMPREF0837_RS00160 ]
- symbol: HMPREF0837_10027
- product: PRD domain protein
- replicon: chromosome
- strand: -
- coordinates: 24673..26304
- length: 1632
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: CP001993 (24673..26304) NCBI
- BioCyc: see HMPREF0837_RS00160
- MicrobesOnline:
- PneumoBrowse for strain D39V: SPV_1841 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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1621ATGGATCAAGAAACGTCCAAAACGATTATGGCGATTTCGAAAGATTTGAAAGAGTCAAGA
AGGAAAATTTATTATCACATTGACAAAATCAATGCTGCTCTGGGTGACGAGGCGCTTCAC
ATCATTAGTATTCCACGAATTGGTATTCACTTAACGGAAGAGCAGAGAGATGCTTGTTGT
AAACTATTATCGGAAGTAGATTCGTACGATTATATCATGAGTGCGCATGAACGTATGATG
ATAATGTTATTATGGATAGGTATTTCTAAAGAACGTATTACGATTGAAAAATTGATAGAG
TTAACAGAGGTATCTAGGAATACTGTTCTCAATGATTTGAATAGTATTCGTTATCAACTA
ACTTTGGAACAATATCAGGTGACCTTGCAAGTGAGCAAGTCACAGGGATACCACCTTCAT
GCCCACCCTCTTAATAAAATTCAGTATCTTCAATCGCTTCTATATCATATTTTTATGGAA
GAAAATGCCACTTTTGTATCTATTTTAGAAGATAAGATGAAAGAGAGGTTAGATGATGAG
TGTTTGCTTTCTGTTGAAATGAACCAATTTTTTAAGGAACAGGTTCCTTTAGTTGAACAA
GATTTAGGGAAGAAAATAAACCATCATGAAATAACTTTTATGTTGCAGGTTCTACCTTAT
TTGCTGTTAAGCTGTCATAATGTTGAACAGTATCAAGAAAGACATCAGGATATAGAGAAA
GAATTTTCTTTGATAAGAAAAAGAATAGAGTATCAGGTGTCTAAGAAATTAGGAGAACGG
TTGTTTCAAAAGTTTGAAATTTCTTTGTCAGGACTTGAAGTTTCTCTTGTAGCTGTTCTC
CTCCTCTCCTATCGTAAAGATTTGGATATTCATGCAGAAAGTGATGATTTTCGGCAATTA
AAACTTGCTTTAGAAGAATTTATCTGGTATTTTGAATCACAAATCCGAATGGAGATTGAG
AACAAGGATGATTTGTTACGAAATTTGATGATCCACTGTAAAGCCTTGTTATTTAGAAAG
ACTTACGGTATTTTTTCTAAAAATCCTCTAACAAAACAAATTCGATCCAAGTATGGAGAA
TTATTTTTAGTCACTAGAAAATCTGCGGAAATTTTAGAAGGAGCATGGTTTATTCGGCTA
ACAGACGATGATATTGCCTATTTGACGATTCATATTGGAGGATTTTTAAAATATACACCA
TCGTCTCAAAAAAATATGAAAAAAGTTTATCTCGTTTGTGATGAAGGTGTTGCGGTTTCG
AGACTTTTGCTGAAACAATGCAAACTTTATTTTCCAAATGAGCAAATTGACACTGTATTT
ACAACAGAACAATTTAAGAGTGTGGAAGATATTGCACAAGTTGATGTAGTGATTACTACT
AATGATGATTTGGATAGCAGATTTCCGATTTTAAGGGTTAATCCTATCCTTGAAGCAGAA
GATATTTTGAAAATGCTAGACTATCTTAAACACAATATATTTCGTAATAAGAGCAAAAGT
TTCAGTGAAAATCTTTCTAGTCTTATTTCGTCTTATATTGTAGACAGCAAGTTGGCTAGT
AAGTTCCAAGAAGAGGTTCAAACACTTATAAATCAAGAAATAGTAGTTCAAGCTTTTTTG
GAAGATATTTGA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: HMPREF0837_10027 [new locus tag: HMPREF0837_RS00160 ]
- symbol: HMPREF0837_10027
- description: PRD domain protein
- length: 543
- theoretical pI: 5.76317
- theoretical MW: 63714.2
- GRAVY: -0.20663
⊟Function[edit | edit source]
- TIGRFAM:
- TheSEED :
- Transcriptional antiterminator with PTS regulation domain, SPy0181 ortholog
- PFAM: PRD (CL0166) PRD; PRD domain (PF00874; HMM-score: 93.2)and 4 moreHTH (CL0123) HTH_11; HTH domain (PF08279; HMM-score: 29.2)Phosphatase (CL0031) PTS_IIB; PTS system, Lactose/Cellobiose specific IIB subunit (PF02302; HMM-score: 17.6)HTH (CL0123) HTH_DeoR; DeoR-like helix-turn-helix domain (PF08220; HMM-score: 15.1)no clan defined BTRD1; Bacterial tandem repeat domain 1 (PF17660; HMM-score: 12)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
- genes regulated by UlaR*, TF important in Ascorbate utilization: in TIGR4
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.002574
- TAT(Tat/SPI): 0.000657
- LIPO(Sec/SPII): 0.000441
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MDQETSKTIMAISKDLKESRRKIYYHIDKINAALGDEALHIISIPRIGIHLTEEQRDACCKLLSEVDSYDYIMSAHERMMIMLLWIGISKERITIEKLIELTEVSRNTVLNDLNSIRYQLTLEQYQVTLQVSKSQGYHLHAHPLNKIQYLQSLLYHIFMEENATFVSILEDKMKERLDDECLLSVEMNQFFKEQVPLVEQDLGKKINHHEITFMLQVLPYLLLSCHNVEQYQERHQDIEKEFSLIRKRIEYQVSKKLGERLFQKFEISLSGLEVSLVAVLLLSYRKDLDIHAESDDFRQLKLALEEFIWYFESQIRMEIENKDDLLRNLMIHCKALLFRKTYGIFSKNPLTKQIRSKYGELFLVTRKSAEILEGAWFIRLTDDDIAYLTIHIGGFLKYTPSSQKNMKKVYLVCDEGVAVSRLLLKQCKLYFPNEQIDTVFTTEQFKSVEDIAQVDVVITTNDDLDSRFPILRVNPILEAEDILKMLDYLKHNIFRNKSKSFSENLSSLISSYIVDSKLASKFQEEVQTLINQEIVVQAFLEDI
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_1841 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
Muhammad Afzal, Sulman Shafeeq, Birgitta Henriques-Normark, Oscar P Kuipers
UlaR activates expression of the ula operon in Streptococcus pneumoniae in the presence of ascorbic acid.
Microbiology (Reading): 2015, 161(Pt 1);41-49
[PubMed:25355938] [WorldCat.org] [DOI] (I p)Sulman Shafeeq, Muhammad Afzal, Birgitta Henriques-Normark, Oscar P Kuipers
Transcriptional profiling of UlaR-regulated genes in Streptococcus pneumoniae.
Genom Data: 2015, 4;57-9
[PubMed:26484177] [WorldCat.org] [DOI] (P e)