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serotype 4
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serotype 2
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serotype 19A
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serotype 6B
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HU-OH
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Hu15
serotype 19A
Hu17
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INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
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NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
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OXC141
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R6
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SP49
serotype 19A
SPN032672
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SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
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ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 28-AUG-2013

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_10718 [new locus tag: HMPREF0837_RS03505 ]
  • pan locus tag?: PNEUPAN001271000
  • symbol: accA
  • pan gene symbol?: accA
  • synonym:
  • product: acetyl-CoA carboxylase, carboxyl transferase, alpha subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_10718 [new locus tag: HMPREF0837_RS03505 ]
  • symbol: accA
  • product: acetyl-CoA carboxylase, carboxyl transferase, alpha subunit
  • replicon: chromosome
  • strand: +
  • coordinates: 654560..655327
  • length: 768
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGAATATTGCAAAAATAGTCAGAGAAGCGCGTGAGCAGAGTCGCTTGACAACCTTGGAC
    TTTGCTACAGGCATTTTTGATGAATTTATCCAATTACATGGTGACCGTTCTTTTCGTGAT
    GATGGTGCAGTTGTTGGTGGTATTGGTTGGCTTGGAGACCAAGCTGTAACAGTGGTTGGT
    ATCCAAAAAGGCAAGAGTTTGCAAGACAACCTCAAACGGAATTTTGGCCAACCACATCCA
    GAAGGCTACCGAAAGGCACTGCGGTTGATGAAACAGGCTGAGAAATTTGGCCGTCCAGTT
    GTGACCTTTATCAATACAGCAGGTGCTTATCCTGGTGTCGGAGCGGAAGAACGTGGTCAA
    GGGGAAGCTATCGCTCGCAATCTCATGGAAATGAGTGACCTGAAAGTTCCTATTATCGCC
    ATTATTATCGGTGAAGGTGGTTCAGGCGGGGCTCTGGCTCTAGCTGTCGCGGACCGTGTC
    TGGATGCTGGAAAATTCTATCTATGCCATTCTCAGTCCAGAAGGCTTTGCTTCCATTTTA
    TGGAAGGACGGTACTCGCGCCATGGAAGCAGCAGAACTGATGAAAATCACTTCGCATGAA
    CTGTTAGAAATGGACGTGGTGGATAAGGTGATTTCTGAAGTAGGACTTTCTAGTAAAGAA
    CTGATTAAGAGTGTCAAAAAAGAACTCCAAACGGAGCTGGCTAGACTTTCACAAAAACCG
    CTAGAAGAGTTGCTGGAAGAACGCTATCAACGATTTAGAAAATACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    768

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_10718 [new locus tag: HMPREF0837_RS03505 ]
  • symbol: AccA
  • description: acetyl-CoA carboxylase, carboxyl transferase, alpha subunit
  • length: 255
  • theoretical pI: 6.31567
  • theoretical MW: 28233.3
  • GRAVY: -0.189412

⊟Function[edit | edit source]

  • reaction:
    EC 6.4.1.2?  ExPASy
    Acetyl-CoA carboxylase ATP + acetyl-CoA + HCO3(-) = ADP + phosphate + malonyl-CoA
  • TIGRFAM:
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis acetyl-CoA carboxylase, carboxyl transferase, alpha subunit (TIGR00513; EC 6.4.1.2; HMM-score: 339.3)
    and 4 more
    Metabolism Transport and binding proteins Cations and iron carrying compounds methylmalonyl-CoA decarboxylase alpha subunit (TIGR01117; EC 4.1.1.41; HMM-score: 33)
    Metabolism Energy metabolism Fermentation methylmalonyl-CoA decarboxylase alpha subunit (TIGR01117; EC 4.1.1.41; HMM-score: 33)
    Metabolism Energy metabolism ATP-proton motive force interconversion methylmalonyl-CoA decarboxylase alpha subunit (TIGR01117; EC 4.1.1.41; HMM-score: 33)
    biotin-independent malonate decarboxylase, gamma subunit (TIGR03134; EC 4.1.1.88; HMM-score: 21.4)
  • TheSEED  :
    • Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2)
    Fatty Acids, Lipids, and Isoprenoids Fatty acids Fatty Acid Biosynthesis FASII  Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2)
  • PFAM:
    ClpP_crotonase (CL0127) ACCA; Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit (PF03255; HMM-score: 126.1)
    and 2 more
    Carboxyl_trans; Carboxyl transferase domain (PF01039; HMM-score: 51.4)
    ECH_1; Enoyl-CoA hydratase/isomerase (PF00378; HMM-score: 20.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.8709
    • Cytoplasmic Membrane Score: 0.105
    • Cell wall & surface Score: 0.001
    • Extracellular Score: 0.0231
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002784
    • TAT(Tat/SPI): 0.000444
    • LIPO(Sec/SPII): 0.000284
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADI68946 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNIAKIVREAREQSRLTTLDFATGIFDEFIQLHGDRSFRDDGAVVGGIGWLGDQAVTVVGIQKGKSLQDNLKRNFGQPHPEGYRKALRLMKQAEKFGRPVVTFINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADRVWMLENSIYAILSPEGFASILWKDGTRAMEAAELMKITSHELLEMDVVDKVISEVGLSSKELIKSVKKELQTELARLSQKPLEELLEERYQRFRKY

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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