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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 23-APR-2025
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae TIGR4
- locus tag: SP_RS02110 [old locus tag: SP_0427 ]
- pan locus tag?: PNEUPAN001271000
- symbol: SP_RS02110
- pan gene symbol?: accA
- synonym:
- product: acetyl-CoA carboxylase carboxyl transferase subunit alpha
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
⊟Accession numbers[edit | edit source]
- Location: NC_003028 (404130..404897) NCBI
- BioCyc:
- MicrobesOnline: see SP_0427
- PneumoBrowse for strain D39V: SPV_0390 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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721ATGAATATTGCAAAAATAGTCAGAGAAGCGCGTGAGCAGAGTCGCTTGACAACCTTGGAC
TTTGCGACAGGCATTTTTGATGAATTTATCCAATTACATGGTGACCGTTCTTTTCGTGAT
GATGGTGCAGTTGTTGGTGGTATTGGTTGGCTTGGAGACCAAGCTGTAACAGTGGTTGGT
ATCCAAAAAGGCAAGAGTTTGCAAGACAACCTCAAACGGAATTTTGGCCAACCACATCCA
GAAGGCTACCGAAAGGCACTGCGGTTGATGAAACAGGCTGAGAAATTTGGCCGTCCAGTT
GTGACCTTTATCAATACAGCAGGTGCTTATCCTGGTGTCGGAGCGGAAGAACGTGGTCAA
GGGGAAGCTATCGCTCGCAATCTCATGGAAATGAGTGACCTGAAAGTTCCTATTATCGCC
ATTATTATCGGTGAAGGTGGTTCAGGCGGGGCTCTGGCTCTAGCTGTCGCGGACCGTGTC
TGGATGCTGGAAAATTCTATCTATGCCATTCTCAGTCCAGAAGGCTTTGCTTCCATTTTA
TGGAAGGACGGTACTCGCGCTATGGAAGCAGCAGAACTGATGAAAATCACTTCGCATGAA
CTGTTAGAAATGGACGTGGTGGATAAGGTGATTTCTGAAATAGGACTTTCTAGTAAAGAA
CTGATTAAGAGTGTCAAAAAAGAACTCCAAACGGAGCTGGCTAGACTTTCACAAAAACCG
CTAGAAGAGTTGCTGGAAGAACGCTATCAACGATTTAGAAAATACTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SP_RS02110 [old locus tag: SP_0427 ]
- symbol: SP_RS02110
- description: acetyl-CoA carboxylase carboxyl transferase subunit alpha
- length: 255
- theoretical pI: 6.31567
- theoretical MW: 28247.4
- GRAVY: -0.188235
⊟Function[edit | edit source]
- TIGRFAM: Fatty acid and phospholipid metabolism Biosynthesis acetyl-CoA carboxylase, carboxyl transferase, alpha subunit (TIGR00513; EC 6.4.1.2; HMM-score: 338.4)and 4 moreTransport and binding proteins Cations and iron carrying compounds methylmalonyl-CoA decarboxylase alpha subunit (TIGR01117; EC 4.1.1.41; HMM-score: 33)Energy metabolism Fermentation methylmalonyl-CoA decarboxylase alpha subunit (TIGR01117; EC 4.1.1.41; HMM-score: 33)Energy metabolism ATP-proton motive force interconversion methylmalonyl-CoA decarboxylase alpha subunit (TIGR01117; EC 4.1.1.41; HMM-score: 33)biotin-independent malonate decarboxylase, gamma subunit (TIGR03134; EC 4.1.1.88; HMM-score: 21.9)
- TheSEED: see SP_0427
- PFAM: ClpP_crotonase (CL0127) ACCA; Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit (PF03255; HMM-score: 126)and 3 moreCarboxyl_trans; Carboxyl transferase domain (PF01039; HMM-score: 51.4)ECH_1; Enoyl-CoA hydratase/isomerase (PF00378; HMM-score: 19.3)no clan defined Imm3; Immunity protein Imm3 (PF14425; HMM-score: 13)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.8784
- Cytoplasmic Membrane Score: 0.0981
- Cell wall & surface Score: 0.0009
- Extracellular Score: 0.0225
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.002784
- TAT(Tat/SPI): 0.000444
- LIPO(Sec/SPII): 0.000284
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MNIAKIVREAREQSRLTTLDFATGIFDEFIQLHGDRSFRDDGAVVGGIGWLGDQAVTVVGIQKGKSLQDNLKRNFGQPHPEGYRKALRLMKQAEKFGRPVVTFINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADRVWMLENSIYAILSPEGFASILWKDGTRAMEAAELMKITSHELLEMDVVDKVISEIGLSSKELIKSVKKELQTELARLSQKPLEELLEERYQRFRKY
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: SP_RS02050 > SP_RS02055 > SP_RS02060 > SP_RS02065 > fabK > fabD > fabG > fabF > accB > fabZ > accC > accD > SP_RS02110 > briC > SP_RS02120 > SP_RS11730
⊟Regulation[edit | edit source]
- regulator: FabT* see SP_0427
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0390 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Jane A Thanassi, Sandra L Hartman-Neumann, Thomas J Dougherty, Brian A Dougherty, Michael J Pucci
Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae.
Nucleic Acids Res: 2002, 30(14);3152-62
[PubMed:12136097] [WorldCat.org] [DOI] (I p)Tim van Opijnen, Andrew Camilli
A fine scale phenotype-genotype virulence map of a bacterial pathogen.
Genome Res: 2012, 22(12);2541-51
[PubMed:22826510] [WorldCat.org] [DOI] (I p)