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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 19-SEP-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_RS00225 [old locus tag: HMPREF0837_10042 ]
  • pan locus tag?: PNEUPAN003611000
  • symbol: HMPREF0837_RS00225
  • pan gene symbol?: —
  • synonym:
  • product: class I SAM-dependent methyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_RS00225 [old locus tag: HMPREF0837_10042 ]
  • symbol: HMPREF0837_RS00225
  • product: class I SAM-dependent methyltransferase
  • replicon: chromosome
  • strand: -
  • coordinates: 36488..37075
  • length: 588
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014251 (36488..37075) NCBI
  • BioCyc: HMPREF0837_RS00225 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_2427 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGAAACATGATTTTAACCACAAAGCAGAAACTTTCGATTCCCCTAAAAATATCTTCCTC
    GCAAACTTGGTATGTCAAGCAGTCGAGAAACAGATTGATATTTTATCAGACAAAGAAATT
    TTAGATTTCGGTGGTGGCACGGGTCTATTAGCCTTGCCCCTAGCCAAGCAGGCTAAGTCA
    GTTACTCTTGTAGACATTTCTGAGAAAATGTTGGAGCAAGCTCGTTTGAAAGCGGAGCAG
    CAAGCAATCAAGAATATCCAGTTTTTGGAGCAAGATTTACCGAAAAATCCCTTGGAGAAA
    GAGTTTGATTGCCTTGCTGTTAGTCGGGTTCTTCATCATATGCCTGATTTGGATGCGGCT
    CTCTCACTGTTTCATCAACATTTGAAGGAAGATGGGAAACTCATCATTGCTGATTTTACC
    AAGACAGAAGCTAATCATCATGGATTTGATTTAGCTGAACTGGAAAACAAGCTAATTGAG
    CATGGTTTTTCATCTGTGAATAGTCAGATTCTCTATAGCGCTGAAGACCTGTTTCAAGGA
    AATTACTCAGAATTCTTTTTAATAGTAGCCCAAAAATCACTCGCCTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    588

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_RS00225 [old locus tag: HMPREF0837_10042 ]
  • symbol: HMPREF0837_RS00225
  • description: class I SAM-dependent methyltransferase
  • length: 195
  • theoretical pI: 5.09478
  • theoretical MW: 21915.9
  • GRAVY: -0.184615

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 3-demethylubiquinone-9 3-O-methyltransferase (TIGR01983; EC 2.1.1.64; HMM-score: 70.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone ubiquinone/menaquinone biosynthesis methyltransferase (TIGR01934; EC 2.1.1.-; HMM-score: 65.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin malonyl-acyl carrier protein O-methyltransferase BioC (TIGR02072; EC 2.1.1.-; HMM-score: 59.5)
    and 23 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll magnesium protoporphyrin O-methyltransferase (TIGR02021; EC 2.1.1.11; HMM-score: 52.9)
    Genetic information processing Protein synthesis tRNA and rRNA base modification 23S rRNA (uracil-5-)-methyltransferase RumA (TIGR00479; EC 2.1.1.-; HMM-score: 40.6)
    Genetic information processing Protein fate Protein modification and repair protein-(glutamine-N5) methyltransferase, release factor-specific (TIGR03534; EC 2.1.1.-; HMM-score: 35.8)
    methyltransferase, Rta_06860 family (TIGR04290; EC 2.1.1.-; HMM-score: 33.8)
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification ribosomal protein L11 methyltransferase (TIGR00406; EC 2.1.1.-; HMM-score: 32.7)
    Genetic information processing Protein fate Protein modification and repair methyltransferase, HemK family (TIGR00536; HMM-score: 32.3)
    Genetic information processing Protein synthesis tRNA and rRNA base modification ribosomal RNA small subunit methyltransferase A (TIGR00755; EC 2.1.1.182; HMM-score: 31)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Glutathione and analogs putative 4-mercaptohistidine N1-methyltranferase (TIGR04345; HMM-score: 30.3)
    Unknown function Enzymes of unknown specificity putative methylase (TIGR00537; HMM-score: 30.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone demethylmenaquinone methyltransferase (TIGR02752; EC 2.1.1.163; HMM-score: 26.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit (TIGR02469; EC 2.1.1.132; HMM-score: 26.4)
    Unknown function Enzymes of unknown specificity tRNA (mo5U34)-methyltransferase (TIGR00452; EC 2.1.1.-; HMM-score: 24.8)
    Genetic information processing Protein synthesis tRNA and rRNA base modification 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG (TIGR00138; EC 2.1.1.170; HMM-score: 24)
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific (TIGR03533; EC 2.1.1.-; HMM-score: 22.2)
    Genetic information processing Transcription RNA processing 3' terminal RNA ribose 2'-O-methyltransferase Hen1 (TIGR04074; EC 2.1.1.-; HMM-score: 21.6)
    Genetic information processing Protein synthesis tRNA and rRNA base modification 3' terminal RNA ribose 2'-O-methyltransferase Hen1 (TIGR04074; EC 2.1.1.-; HMM-score: 21.6)
    putative methyltransferase, LIC12133 family (TIGR04325; EC 2.1.1.-; HMM-score: 21)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA (uracil(54)-C(5))-methyltransferase (TIGR02143; EC 2.1.1.35; HMM-score: 17.3)
    Cellular processes Cellular processes Toxin production and resistance tellurite resistance protein TehB (TIGR00477; HMM-score: 13.8)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA (guanine-N(7)-)-methyltransferase (TIGR00091; EC 2.1.1.33; HMM-score: 12.5)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides putative sugar O-methyltransferase (TIGR04371; EC 2.1.1.-; HMM-score: 12.4)
    Genetic information processing Protein synthesis tRNA and rRNA base modification 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD (TIGR00095; EC 2.1.1.171; HMM-score: 12.3)
    methyltransferase, FxLD system (TIGR04364; HMM-score: 10.7)
  • TheSEED: see HMPREF0837_10042
  • PFAM:
    NADP_Rossmann (CL0063) Methyltransf_25; Methyltransferase domain (PF13649; HMM-score: 70.6)
    Methyltransf_31; Methyltransferase domain (PF13847; HMM-score: 70.4)
    Methyltransf_11; Methyltransferase domain (PF08241; HMM-score: 67.9)
    Methyltransf_23; Methyltransferase domain (PF13489; HMM-score: 65.2)
    Methyltransf_12; Methyltransferase domain (PF08242; HMM-score: 63.8)
    and 24 more
    Ubie_methyltran; ubiE/COQ5 methyltransferase family (PF01209; HMM-score: 55.6)
    MTS; Methyltransferase small domain (PF05175; HMM-score: 45.4)
    NodS; Nodulation protein S (NodS) (PF05401; HMM-score: 32.1)
    RrnaAD; Ribosomal RNA adenine dimethylase (PF00398; HMM-score: 30.8)
    Methyltransf_2; O-methyltransferase domain (PF00891; HMM-score: 30.6)
    PrmA; Ribosomal protein L11 methyltransferase (PrmA) (PF06325; HMM-score: 26)
    GidB; rRNA small subunit methyltransferase G (PF02527; HMM-score: 24.4)
    Methyltransf_PK; AdoMet dependent proline di-methyltransferase (PF05891; HMM-score: 21.1)
    Methyltransf_32; Methyltransferase domain (PF13679; HMM-score: 20.8)
    Methyltransf_16; Lysine methyltransferase (PF10294; HMM-score: 20.3)
    TehB; Tellurite resistance protein TehB (PF03848; HMM-score: 20.2)
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) (PF01135; HMM-score: 18.6)
    Methyltransf_9; Protein of unknown function (DUF1698) (PF08003; HMM-score: 18)
    BpsA_C; Branched-chain polyamine synthase A C-terminal domain (PF01861; HMM-score: 16.6)
    Methyltransf_4; Putative methyltransferase (PF02390; HMM-score: 16.4)
    tRNA_U5-meth_tr; tRNA (Uracil-5-)-methyltransferase (PF05958; HMM-score: 16.4)
    CheR; CheR methyltransferase, SAM binding domain (PF01739; HMM-score: 15.3)
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family (PF01234; HMM-score: 14.5)
    Bmt2; 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 (PF11968; HMM-score: 14.5)
    Methyltransf_18; Methyltransferase domain (PF12847; HMM-score: 14.3)
    Spermine_synth; Spermine/spermidine synthase domain (PF01564; HMM-score: 14.1)
    PDDEXK (CL0236) RE_TaqI; TaqI restriction endonuclease (PF09573; HMM-score: 13.5)
    NADP_Rossmann (CL0063) Cons_hypoth95; Conserved hypothetical protein 95 (PF03602; HMM-score: 12.1)
    DREV; DREV methyltransferase (PF05219; HMM-score: 11.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.010063
    • TAT(Tat/SPI): 0.005647
    • LIPO(Sec/SPII): 0.001574
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKHDFNHKAETFDSPKNIFLANLVCQAVEKQIDILSDKEILDFGGGTGLLALPLAKQAKSVTLVDISEKMLEQARLKAEQQAIKNIQFLEQDLPKNPLEKEFDCLAVSRVLHHMPDLDAALSLFHQHLKEDGKLIIADFTKTEANHHGFDLAELENKLIEHGFSSVNSQILYSAEDLFQGNYSEFFLIVAQKSLA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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