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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 25-OCT-2024

Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_RS03665
  • pan locus tag?: PNEUPAN001318000
  • symbol: rlrA
  • pan gene symbol?: rlrA
  • synonym:
  • product: PI-1 pilus transcriptional regulator RlrA

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS, pseudogene
  • locus tag: HMPREF0837_RS03665
  • symbol: rlrA
  • product: PI-1 pilus transcriptional regulator RlrA
  • replicon: chromosome
  • strand: -
  • coordinates: 686805..688333
  • length: 1529
  • essential: unknown

Accession numbers[edit | edit source]

  • Location: NC_014251 (686805..688333) NCBI
  • BioCyc: HMPREF0837_RS03665 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    ATGCTAAACAAATACATTGAAAAAAGAATTACAGATAAAATTACCATTTTAAATATATTA
    TTGGATATTCGGTCTATTGAACTAGATGAACTGTCTACTTTAACTTCATTACAATCTAAA
    AGTCTCCTAAGCATTTTGCAGGAATTACAAGAAACATTCGAGGAAGAGTTGACATTTAAT
    TTAGATACGCAACAAGTTCAATTAATCGAACACCATTCTCATCAAACGAATTATTACTTC
    CATCAGCTTTATAACCAATCAACTATTTTAAAAATACTCCGCTTCTTTCTACTACAAGGT
    AATCAAAGCTTTAACGAATTTACACAAAAAGAGTATATTTCCATCGCAACAGGCTACCGC
    GTACGACAAAAGTGTGGCTTGTTACTACGTTCAGTAGGTTTGGACCTTGTGAAAAATCAA
    GTAGTTGGTCCTGAATATCGCATTCGTTTTTTAATTGCACTCCTCCAGTTTCATTTTGGT
    ATTGAGATTTATGATTTGAATGATGGAAGTATGGATTGGGTCACACATATGATTGTGCAG
    TCTAATTCTCAACTCAGTCATGAACTGTTAGAAATCACACCTGACGAGTATGTTCATTTT
    AGCATACTAGTGGCACTCACTTGGAAACGTCGGGAATTTCCACTTGAGTTCCCTGAGTCC
    AAAGAGTTTGAAAAATTAAAAAACCTCTTTATGTATCCGATTTTGATGGAACATTGCCAA
    ACTTACTTAGAGCCACATGCCAACATGACTTTTACTCAGGAAGAACTGGATTATATCTTT
    TTGGTTTATTGTTCTGCTAATTCTTCGTTTTCCAAGGACAAATGGAATCAAGAAAAAAGA
    CTCATACTATTCAACTGATTCTTCAGCATACAAGAGGAAAGCATCTACTATCCAAGTTCA
    AGAATATCTTAGGAAATGACATTTCGAATTCTCTTTCTTTTTTAACAGCACTGACTTTCT
    TAACAAGAACGTTTTTGTTTGGTTTACAAAATCTAGTTCCCTATTATAATTATTACGAAC
    ATTATGGGATTGAAAGCGACAAGCCACTGTATCATATTTCGAAAGCAATTGTTCAAGAGT
    GGATGACTGAGCAGAAGATTGAAGGAGTTATCGACCAGCATCGGCTGTACCTTTTCTCAC
    TCTACTTGACAGAAACCATCTTTTCCTCACTACCTGCTATCCCGATTTTTATCATTTTAA
    ATAATCAAGCAGATGTAAACTTAATAAAGTCCATTATTTTACGGAATTTTACTGACAAAG
    TTGCCTCTGTTACAGGATACAATATTCTAATTAGTCCTCCTCCTTCAGAGGAGCATTTGA
    CAGAGCCATTGATTATTATTACAACGAAAGAATACCTGCCTTACGTTAAAAAGCAGTATC
    CCAAAGGGAAACATCACTTTTTGACGATTGCCTTAGATTTGCATGTTAGCCAACAGCGTC
    TCATCTATCAGACAATTGTAGATATCCGAAAAGAGGCTTTTGACAAACGGGTCGCAATGA
    TTGCTAAAAAGGCTCACTATTTGTTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1529

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: HMPREF0837_RS03665
  • symbol: RlrA
  • description: PI-1 pilus transcriptional regulator RlrA
  • length:
  • theoretical pI:
  • theoretical MW:
  • GRAVY:

Function[edit | edit source]

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb:
  • DeepLocPro:
  • SignalP:
  • predicted transmembrane helices (TMHMM):

Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

Protein sequence[edit | edit source]

Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription[edit | edit source]

  • transcription start site:

Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]

David L Hava, Carolyn J Hemsley, Andrew Camilli
Transcriptional regulation in the Streptococcus pneumoniae rlrA pathogenicity islet by RlrA.
J Bacteriol: 2003, 185(2);413-21
[PubMed:12511486] [WorldCat.org] [DOI] (P p)
Julianna LeMieux, David L Hava, Alan Basset, Andrew Camilli
RrgA and RrgB are components of a multisubunit pilus encoded by the Streptococcus pneumoniae rlrA pathogenicity islet.
Infect Immun: 2006, 74(4);2453-6
[PubMed:16552078] [WorldCat.org] [DOI] (P p)
Jason W Rosch, Beth Mann, Justin Thornton, Jack Sublett, Elaine Tuomanen
Convergence of regulatory networks on the pilus locus of Streptococcus pneumoniae.
Infect Immun: 2008, 76(7);3187-96
[PubMed:18443093] [WorldCat.org] [DOI] (I p)
Bernd Kreikemeyer, Gustavo Gámez, Immaculada Margarit, Jean-Christophe Giard, Sven Hammerschmidt, Axel Hartke, Andreas Podbielski
Genomic organization, structure, regulation and pathogenic role of pilus constituents in major pathogenic Streptococci and Enterococci.
Int J Med Microbiol: 2011, 301(3);240-51
[PubMed:21112248] [WorldCat.org] [DOI] (I p)