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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Taiwan19F-14
  • locus tag: SPT_RS02495 [old locus tag: SPT_0500 ]
  • pan locus tag?: PNEUPAN001318000
  • symbol: rlrA
  • pan gene symbol?: rlrA
  • synonym:
  • product: PI-1 pilus transcriptional regulator RlrA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPT_RS02495 [old locus tag: SPT_0500 ]
  • symbol: rlrA
  • product: PI-1 pilus transcriptional regulator RlrA
  • replicon: chromosome
  • strand: -
  • coordinates: 461532..463061
  • length: 1530
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_012469 (461532..463061) NCBI
  • BioCyc: SPT_RS02495 BioCyc
  • MicrobesOnline: see SPT_0500
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    ATGCTAAACAAATACATTGAAAAAAGAATTACAGATAAAATTACCATTTTAAATATATTA
    TTGGATATTCGGTCTATTGAACTAGATGAACTGTCTACTTTAACTTCATTACAATCTAAA
    AGTCTCCTAAGCATTTTGCAGGAATTACAAGAAACATTCGAGGAAGAGTTGACATTTAAT
    TTAGATACGCAACAAGTTCAATTAATCGAACACCATTCTCATCAAACGAATTATTACTTC
    CATCAGCTTTATAACCAATCAACTATTTTAAAAATACTCCGCTTCTTTCTACTACAAGGT
    AATCAAAGCTTTAACGAATTTACACAAAAAGAGTATATTTCCATCGCAACAGGCTACCGC
    GTACGACAAAAGTGTGGCTTGTTACTACGTTCAGTAGGTTTGGACCTTGTGAAAAATCAA
    GTAGTTGGTCCTGAATATCGCATTCGTTTTTTAATTGCACTCCTCCAGTTTCATTTTGGT
    ATTGAGATTTATGATTTGAATGATGGAAGTATGGATTGGGTCACACATATGATTGTGCAG
    TCTAATTCTCAACTCAGTCATGAACTGTTAGAAATCACACCTGACGAGTATGTTCATTTT
    AGCATACTAGTGGCACTCACTTGGAAACGTCGGGAATTTCCACTTGAGTTCCCTGAGTCC
    AAAGAGTTTGAAAAATTAAAAAACCTCTTTATGTATCCGATTTTGATGGAACATTGCCAA
    ACTTACTTAGAGCCACATGCCAACATGACTTTTACTCAGGAAGAACTGGATTATATCTTT
    TTGGTTTATTGTTCTGCTAATTCTTCGTTTTCCAAGGACAAATGGAATCAAGAAAAAAAG
    ACTCATACTATTCAACTGATTCTTCAGCATACAAGAGGAAAGCATCTACTATCCAAGTTC
    AAGAATATCTTAGGAAATGACATTTCGAATTCTCTTTCTTTTTTAACAGCACTGACTTTC
    TTAACAAGAACGTTTTTGTTTGGTTTACAAAATCTAGTTCCCTATTATAATTATTACGAA
    CATTATGGGATTGAAAGCGACAAGCCACTGTATCATATTTCGAAAGCAATTGTTCAAGAG
    TGGATGACTGAGCAGAAGATTGAAGGAGTTATCGACCAGCATCGGCTGTACCTTTTCTCA
    CTCTACTTGACAGAAACCATCTTTTCCTCACTACCTGCTATCCCGATTTTTATCATTTTA
    AATAATCAAGCAGATGTAAACTTAATAAAGTCCATTATTTTACGGAATTTTACTGACAAA
    GTTGCCTCTGTTACAGGATACAATATTCTAATTAGTCCTCCTCCTTCAGAGGAGCATTTG
    ACAGAGCCATTGATTATTATTACAACGAAAGAATACCTGCCTTACGTTAAAAAGCAGTAT
    CCCAAAGGGAAACATCACTTTTTGACGATTGCCTTAGATTTGCATGTTAGCCAACAGCGT
    CTCATCTATCAGACAATTGTAGATATCCGAAAAGAGGCTTTTGACAAACGGGTCGCAATG
    ATTGCTAAAAAGGCTCACTATTTGTTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1530

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPT_RS02495 [old locus tag: SPT_0500 ]
  • symbol: RlrA
  • description: PI-1 pilus transcriptional regulator RlrA
  • length: 509
  • theoretical pI: 6.89449
  • theoretical MW: 59912.8
  • GRAVY: -0.136346

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Central intermediary metabolism Amino sugars glucosamine-6-phosphate deaminase (TIGR00502; EC 3.5.99.6; HMM-score: 12.7)
  • TheSEED: see SPT_0500
  • PFAM:
    HTH (CL0123) HTH_Mga; M protein trans-acting positive regulator (MGA) HTH domain (PF08280; HMM-score: 49.9)
    Mga; Mga helix-turn-helix domain (PF05043; HMM-score: 42)
    PRD (CL0166) PRD_Mga; M protein trans-acting positive regulator (MGA) PRD domain (PF08270; HMM-score: 40.8)
    and 2 more
    Phage_barrel (CL0504) Prophage_tail; Prophage endopeptidase tail (PF06605; HMM-score: 16.7)
    Homing_endonuc (CL0324) LAGLIDADG_1; LAGLIDADG endonuclease (PF00961; HMM-score: 9.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.32
    • Cytoplasmic Membrane Score: 9.55
    • Cellwall Score: 0.12
    • Extracellular Score: 0.01
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.7977
    • Cytoplasmic Membrane Score: 0.179
    • Cell wall & surface Score: 0.0006
    • Extracellular Score: 0.0226
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006124
    • TAT(Tat/SPI): 0.000098
    • LIPO(Sec/SPII): 0.000299
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000933117 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLNKYIEKRITDKITILNILLDIRSIELDELSTLTSLQSKSLLSILQELQETFEEELTFNLDTQQVQLIEHHSHQTNYYFHQLYNQSTILKILRFFLLQGNQSFNEFTQKEYISIATGYRVRQKCGLLLRSVGLDLVKNQVVGPEYRIRFLIALLQFHFGIEIYDLNDGSMDWVTHMIVQSNSQLSHELLEITPDEYVHFSILVALTWKRREFPLEFPESKEFEKLKNLFMYPILMEHCQTYLEPHANMTFTQEELDYIFLVYCSANSSFSKDKWNQEKKTHTIQLILQHTRGKHLLSKFKNILGNDISNSLSFLTALTFLTRTFLFGLQNLVPYYNYYEHYGIESDKPLYHISKAIVQEWMTEQKIEGVIDQHRLYLFSLYLTETIFSSLPAIPIFIILNNQADVNLIKSIILRNFTDKVASVTGYNILISPPPSEEHLTEPLIIITTKEYLPYVKKQYPKGKHHFLTIALDLHVSQQRLIYQTIVDIRKEAFDKRVAMIAKKAHYLL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

David L Hava, Carolyn J Hemsley, Andrew Camilli
Transcriptional regulation in the Streptococcus pneumoniae rlrA pathogenicity islet by RlrA.
J Bacteriol: 2003, 185(2);413-21
[PubMed:12511486] [WorldCat.org] [DOI] (P p)Julianna LeMieux, David L Hava, Alan Basset, Andrew Camilli
RrgA and RrgB are components of a multisubunit pilus encoded by the Streptococcus pneumoniae rlrA pathogenicity islet.
Infect Immun: 2006, 74(4);2453-6
[PubMed:16552078] [WorldCat.org] [DOI] (P p)Jason W Rosch, Beth Mann, Justin Thornton, Jack Sublett, Elaine Tuomanen
Convergence of regulatory networks on the pilus locus of Streptococcus pneumoniae.
Infect Immun: 2008, 76(7);3187-96
[PubMed:18443093] [WorldCat.org] [DOI] (I p)Bernd Kreikemeyer, Gustavo Gámez, Immaculada Margarit, Jean-Christophe Giard, Sven Hammerschmidt, Axel Hartke, Andreas Podbielski
Genomic organization, structure, regulation and pathogenic role of pilus constituents in major pathogenic Streptococci and Enterococci.
Int J Med Microbiol: 2011, 301(3);240-51
[PubMed:21112248] [WorldCat.org] [DOI] (I p)

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