PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 19-SEP-2021

⊟Summary

• organism: Streptococcus pneumoniae TCH8431/19A
• locus tag: HMPREF0837_RS04340 [old locus tag: HMPREF0837_10899 ]
• pan locus tag^?: PNEUPAN001537000
• symbol: HMPREF0837_RS04340
• pan gene symbol^?: glnH2
• synonym:
• product: transporter substrate-binding domain-containing protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: HMPREF0837_RS04340 [old locus tag: HMPREF0837_10899 ]
• symbol: HMPREF0837_RS04340
• product: transporter substrate-binding domain-containing protein
• replicon: chromosome
• strand: -
• coordinates: 821434..822198
• length: 765
• essential: unknown

⊟Accession numbers

• Location: NC_014251 (821434..822198) NCBI
• BioCyc: HMPREF0837_RS04340 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0530 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
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  721
  
  TTGATTAGCCTTTTCGGCCTTGCTGCTGCCAAACCAGTCCAGGCTGATACAAGTATCGCA
  GACATTCAAAAAAGAGGCGAACTGGTTGTCGGTGTCAAACAAGACGTTCCCAATTTTGGT
  TACAAAGATCCCAAGACCGGTACTTATTCTGGTATCGAAACCGACTTGGCCAAGATGGTA
  GCTGATGAACTCAAGGTCAAGATTCGCTATGTGCCGGTTACAGCACAAACCCGCGGCCCC
  CTTCTAGACAATGAACAGGTCGATATGGATATCGCGACCTTTACCATCACGGACGAACGC
  AAAAAACTCTACAACTTTACCAGTCCCTACTACACAGACGCTTCTGGATTTTTGGTCAAT
  AAATCTGCCAAAATCAAAAAGATTGAGGACCTAAACAGCAAAACCATCGGAGTCGCCCAA
  GGCTCCATCACCCAATGCCTGATTACTGAACTGGGCAAAAAGAAAGGTCTAACCTTTAAA
  TTTGTCGAACTTGGTTCCTACCCAGAATTGATTACTTCCCTTCACGCTCATCGTATCGAT
  GCCTTTTCCGTTGACCGCTCTATTCTGTCTGGCTACACTAGTAAACGCACAGAACTACTA
  GATGATAGTTTCAAGCCATCTGACTACGGTATTGTTACCAAGAAATCAAATACAGAGCTC
  AACGACTATCTTGATAACTTGGTTACTAAATGGAGCAAGGATGGTAGTTTGCAGAAACTT
  TATGACCGTTACAAGCTCAAACCATCTAGCCATACTGCAGATTAA
  60
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  765
  

⊟Protein

⊟General

• locus tag: HMPREF0837_RS04340 [old locus tag: HMPREF0837_10899 ]
• symbol: HMPREF0837_RS04340
• description: transporter substrate-binding domain-containing protein
• length: 254
• theoretical pI: 9.05404
• theoretical MW: 28255
• GRAVY: -0.398425

⊟Function

• TIGRFAM:
  Metabolism Transport and binding proteins Amino acids, peptides and amines lysine-arginine-ornithine-binding periplasmic protein (TIGR01096; HMM-score: 143.8)
  and 7 more
  Metabolism Transport and binding proteins Amino acids, peptides and amines ectoine/hydroxyectoine ABC transporter solute-binding protein EhuB (TIGR02995; HMM-score: 43.4)
  Metabolism Transport and binding proteins Other ABC transporter, substrate-binding protein, aliphatic sulfonates family (TIGR01728; HMM-score: 23.3)
  quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein (TIGR03871; HMM-score: 19.8)
  Metabolism Energy metabolism Other methanol oxidation system protein MoxJ (TIGR03870; HMM-score: 18.2)
  Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids methanol oxidation system protein MoxJ (TIGR03870; HMM-score: 18.2)
  Metabolism Transport and binding proteins Unknown substrate TRAP transporter solute receptor, TAXI family (TIGR02122; HMM-score: 17.9)
  Metabolism Transport and binding proteins Anions phosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein (TIGR01098; HMM-score: 17.3)
• TheSEED: see HMPREF0837_10899
• PFAM:
  PBP (CL0177) SBP_bac_3; Bacterial extracellular solute-binding proteins, family 3 (PF00497; HMM-score: 164.8)
  and 5 more
  NMT1; NMT1/THI5 like (PF09084; HMM-score: 33)
  Lig_chan-Glu_bd; Ligated ion channel L-glutamate- and glycine-binding site (PF10613; HMM-score: 27.4)
  Phosphonate-bd; ABC transporter, phosphonate, periplasmic substrate-binding protein (PF12974; HMM-score: 24.5)
  YhfZ_C; YhfZ C-terminal domain (PF14503; HMM-score: 20.2)
  NMT1_3; NMT1-like family (PF16868; HMM-score: 13.1)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.179434
  • TAT(Tat/SPI): 0.004974
  • LIPO(Sec/SPII): 0.012236
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000624342 NCBI
• UniProt: see HMPREF0837_10899

⊟Protein sequence

• MISLFGLAAAKPVQADTSIADIQKRGELVVGVKQDVPNFGYKDPKTGTYSGIETDLAKMVADELKVKIRYVPVTAQTRGPLLDNEQVDMDIATFTITDERKKLYNFTSPYYTDASGFLVNKSAKIKKIEDLNSKTIGVAQGSITQCLITELGKKKGLTFKFVELGSYPELITSLHAHRIDAFSVDRSILSGYTSKRTELLDDSFKPSDYGIVTKKSNTELNDYLDNLVTKWSKDGSLQKLYDRYKLKPSSHTAD

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_0530 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications