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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 25-OCT-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_RS08835 [old locus tag: HMPREF0837_11845 ]
  • pan locus tag?: PNEUPAN003012000
  • symbol: HMPREF0837_RS08835
  • pan gene symbol?: hcnC
  • synonym:
  • product: NAD(P)/FAD-dependent oxidoreductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_RS08835 [old locus tag: HMPREF0837_11845 ]
  • symbol: HMPREF0837_RS08835
  • product: NAD(P)/FAD-dependent oxidoreductase
  • replicon: chromosome
  • strand: -
  • coordinates: 1692155..1693258
  • length: 1104
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014251 (1692155..1693258) NCBI
  • BioCyc: HMPREF0837_RS08835 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1433 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    ATGAAAAAAGTTGCCATTATTGGAGCAGGAATTGTGGGAGCAACAGCTGCCTACTACCTC
    TCGAGAGAAAGTGACCTAGAGGTGACCGTTTTTGACCATGAGCAAGGTCAAGCCACCAAG
    GCCGCAGCAGGAATTATCAGTCCTTGGTTTTCCAAACGCCGTAATAAAGCCTGGTACAAG
    ATGGCGCGCTTGGGGGCTGACTTTTATGTGGATTTATTAGCTGATTTAGAGAAATCAGGA
    CAAAAAATCGACTTTTACCAGCGTTCGGGAGTCTTTCTCTTGAAAAAGGATGAATCCAAG
    TTGGAAGAACTTTATCAACTGGCCCTCCAGCGCAGAGAAGAATCTCCCTTGATAGGGCAA
    TTAGCCATTCTGGACCAAGCTTCAGCTAATGAATTATTCCCTGGTTTGCAGGGATTTGAC
    CGCCTGCTCTATGCTTCTGGTGGAGCGAGAGTAGATGGCCAACTCTTGGTAACTCGTCTG
    CTAGAAGCCAGTCATGTCAAGCTGGTCAAAGAAAAAGTGACTCTGACACTCTTATCATCA
    GGCTACCAGATTGGCGAAGAGGTGTTTGATCAGGTTATTTTGGCAACGGGAGCTTGGTTG
    GGGGACATGTTAGAGCCTTTAGGTTATGAAGTGGATGTCCGTCCTCAAAAAGGACAACTA
    CGGGATTATCAGCTTGCCCAAGACATGGAAGATTACCCTGTTGTCATGCCAGAAGGGGAG
    TGGGATTTGATTCCTTTTGCAGGTGGGAAATTGTCCTTAGGCGCTACCCACGAAAATGAC
    ATGGGATTTGATTTGACGGTAGATGAAACCTTGCTCCAACAAATGGAGGAGGCCACCTTG
    ACTCACTATCTGATTTTGGCTGAAGCTACTTCAAAATCTGAGCGTGTGGGAATCCGTGCC
    TATACCAGTGATTTCTCTCCCTTCTTTGGGCAGGTGCCAGAATTGGCAGGTGTCTATGCA
    GCCAGTGGACTAGGTTCATCAGGCCTCACAACTGGTCCTATCATTGGTTACCATCTAGCC
    CAACTGATCCAAGACAAGGAGTTGATCTTGGACCCTCTAAATTACCCAATTGAAAACTAT
    GTCAAACGAGTAAAAAGCGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1104

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_RS08835 [old locus tag: HMPREF0837_11845 ]
  • symbol: HMPREF0837_RS08835
  • description: NAD(P)/FAD-dependent oxidoreductase
  • length: 367
  • theoretical pI: 4.54279
  • theoretical MW: 40612
  • GRAVY: -0.126158

⊟Function[edit | edit source]

  • reaction:
    EC 1.-.-.-?  ExPASy
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine glycine oxidase ThiO (TIGR02352; EC 1.4.3.19; HMM-score: 119.1)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain (TIGR03197; HMM-score: 98.5)
    and 21 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll geranylgeranyl reductase family (TIGR02032; EC 1.3.1.-; HMM-score: 22)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 2-polyprenyl-6-methoxyphenol 4-hydroxylase (TIGR01984; EC 1.14.13.-; HMM-score: 21.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family (TIGR01988; EC 1.14.13.-; HMM-score: 20.8)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin protoporphyrinogen oxidase (TIGR00562; EC 1.3.3.4; HMM-score: 20.6)
    Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, beta subunit family (TIGR01373; HMM-score: 19.7)
    FAD dependent oxidoreductase TIGR03364 (TIGR03364; HMM-score: 18.8)
    putative selenate reductase, YgfK subunit (TIGR03315; HMM-score: 17.7)
    Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, monomeric form (TIGR01377; HMM-score: 17.6)
    Metabolism Energy metabolism TCA cycle malate dehydrogenase, NAD-dependent (TIGR01763; EC 1.1.1.37; HMM-score: 15.7)
    nucleotide sugar dehydrogenase (TIGR03026; HMM-score: 15.2)
    Metabolism Energy metabolism Electron transport thioredoxin-disulfide reductase (TIGR01292; EC 1.8.1.9; HMM-score: 14.7)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine thiazole biosynthesis enzyme (TIGR00292; HMM-score: 14.3)
    Metabolism Amino acid biosynthesis Other pyrrolysine biosynthesis protein PylD (TIGR03911; HMM-score: 14)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A 2-dehydropantoate 2-reductase (TIGR00745; EC 1.1.1.-; HMM-score: 13.9)
    Unknown function Enzymes of unknown specificity GMC family mycofactocin-associated oxidreductase (TIGR04542; EC 1.-.-.-; HMM-score: 13.9)
    salicylate 1-monooxygenase (TIGR03219; EC 1.14.13.1; HMM-score: 12.6)
    Metabolism Energy metabolism Anaerobic glycerol-3-phosphate dehydrogenase, anaerobic, A subunit (TIGR03377; EC 1.1.5.3; HMM-score: 11.6)
    squalene-associated FAD-dependent desaturase (TIGR03467; HMM-score: 11.3)
    Unknown function Enzymes of unknown specificity flavoprotein, HI0933 family (TIGR00275; HMM-score: 11.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other C-3',4' desaturase CrtD (TIGR02733; EC 1.3.99.-; HMM-score: 10.7)
    glutamate synthase, small subunit (TIGR01318; HMM-score: 10.2)
  • TheSEED: see HMPREF0837_11845
  • PFAM:
    NADP_Rossmann (CL0063) DAO; FAD dependent oxidoreductase (PF01266; HMM-score: 155)
    and 19 more
    NAD_binding_8; NAD(P)-binding Rossmann-like domain (PF13450; HMM-score: 29.8)
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 25.8)
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (PF02737; HMM-score: 22.1)
    Thi4; Thi4 family (PF01946; HMM-score: 20.6)
    Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain (PF03435; HMM-score: 19.3)
    ApbA; Ketopantoate reductase PanE/ApbA (PF02558; HMM-score: 19)
    NAD_binding_9; FAD-NAD(P)-binding (PF13454; HMM-score: 18.8)
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase (PF00070; HMM-score: 16.2)
    FAD_binding_2; FAD binding domain (PF00890; HMM-score: 15)
    GIDA; Glucose inhibited division protein A (PF01134; HMM-score: 13.5)
    AlaDh_PNT_C; Alanine dehydrogenase/PNT, C-terminal domain (PF01262; HMM-score: 13.5)
    TrkA_N; TrkA-N domain (PF02254; HMM-score: 13.5)
    UDPG_MGDP_dh_N; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain (PF03721; HMM-score: 13.5)
    NAD_binding_7; Putative NAD(P)-binding (PF13241; HMM-score: 13.4)
    Shikimate_DH; Shikimate / quinate 5-dehydrogenase (PF01488; HMM-score: 12.2)
    IlvN; Acetohydroxy acid isomeroreductase, NADPH-binding domain (PF07991; HMM-score: 12)
    PDDEXK (CL0236) RE_ApaLI; ApaLI-like restriction endonuclease (PF09499; HMM-score: 11.3)
    NADP_Rossmann (CL0063) HI0933_like; HI0933-like protein (PF03486; HMM-score: 11)
    Trp_halogenase; Tryptophan halogenase (PF04820; HMM-score: 10.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9978
    • Cytoplasmic Membrane Score: 0.0015
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0005
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.240912
    • TAT(Tat/SPI): 0.004302
    • LIPO(Sec/SPII): 0.085767
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000754674 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKKVAIIGAGIVGATAAYYLSRESDLEVTVFDHEQGQATKAAAGIISPWFSKRRNKAWYKMARLGADFYVDLLADLEKSGQKIDFYQRSGVFLLKKDESKLEELYQLALQRREESPLIGQLAILDQASANELFPGLQGFDRLLYASGGARVDGQLLVTRLLEASHVKLVKEKVTLTLLSSGYQIGEEVFDQVILATGAWLGDMLEPLGYEVDVRPQKGQLRDYQLAQDMEDYPVVMPEGEWDLIPFAGGKLSLGATHENDMGFDLTVDETLLQQMEEATLTHYLILAEATSKSERVGIRAYTSDFSPFFGQVPELAGVYAASGLGSSGLTTGPIIGYHLAQLIQDKELILDPLNYPIENYVKRVKSE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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