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serotype 2
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SPNA45
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ST556
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TCH8431/19A
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serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-AUG-2013

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae gamPNI0373
  • locus tag: HMPREF1038_01066 [new locus tag: HMPREF1038_RS05255 ]
  • pan locus tag?: PNEUPAN002251000
  • symbol: HMPREF1038_01066
  • pan gene symbol?: hlpA
  • synonym:
  • product: DNA-binding protein HU

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF1038_01066 [new locus tag: HMPREF1038_RS05255 ]
  • symbol: HMPREF1038_01066
  • product: DNA-binding protein HU
  • replicon: chromosome
  • strand: -
  • coordinates: 993322..993597
  • length: 276
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    ATGGCAAACAAACAAGATTTGATCGCTAAAGTAGCAGAAGCTACAGAATTGACTAAGAAA
    GACTCAGCAGCAGCAGTTGAAGCTGTATTTGCAGCAGTAGCTGACTATCTTGCAGCTGGT
    GAAAAAGTTCAGTTGATCGGTTTTGGTAACTTTGAAGTTCGTGAGCGCGCAGAACGTAAA
    GGTCGCAACCCACAAACTGGTAAAGAAATGACAATTGCAGCTTCTAAAGTACCAGCATTC
    AAAGCTGGTAAAGCTCTTAAAGACGCTGTTAAATAA
    60
    120
    180
    240
    276

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF1038_01066 [new locus tag: HMPREF1038_RS05255 ]
  • symbol: HMPREF1038_01066
  • description: DNA-binding protein HU
  • length: 91
  • theoretical pI: 10.2074
  • theoretical MW: 9650.07
  • GRAVY: -0.241758

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair integration host factor, beta subunit (TIGR00988; HMM-score: 77.3)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair integration host factor, alpha subunit (TIGR00987; HMM-score: 75.6)
    and 1 more
    Genetic information processing DNA metabolism Chromosome-associated proteins putative DNA-binding protein (TIGR01201; HMM-score: 23.3)
  • TheSEED  :
    • DNA-binding protein HBsu
    DNA Metabolism DNA Metabolism - no subcategory DNA structural proteins, bacterial  DNA-binding protein HBsu
  • PFAM:
    IHF-likeDNA-bdg (CL0548) Bac_DNA_binding; Bacterial DNA-binding protein (PF00216; HMM-score: 116.4)
    and 7 more
    HU-HIG; HU domain fused to wHTH, Ig, or Glycine-rich motif (PF18291; HMM-score: 34.3)
    no clan defined DUF2267; Uncharacterized conserved protein (DUF2267) (PF10025; HMM-score: 18.7)
    IHF-likeDNA-bdg (CL0548) HU-CCDC81_euk_2; CCDC81 eukaryotic HU domain 2 (PF18289; HMM-score: 14.8)
    HU-DNA_bdg; DNA-binding domain (PF14848; HMM-score: 14.2)
    no clan defined ADP_ribosyl_GH; ADP-ribosylglycohydrolase (PF03747; HMM-score: 12.9)
    IHF-likeDNA-bdg (CL0548) HU-CCDC81_bac_2; CCDC81-like prokaryotic HU domain 2 (PF18175; HMM-score: 12.3)
    no clan defined Rpf1_C; Resuscitation-promoting factor Rpf1, C-terminal (PF11574; HMM-score: 9.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9563
    • Cytoplasmic Membrane Score: 0.0006
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0429
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004297
    • TAT(Tat/SPI): 0.001455
    • LIPO(Sec/SPII): 0.000635
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: AFS43116 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MANKQDLIAKVAEATELTKKDSAAAVEAVFAAVADYLAAGEKVQLIGFGNFEVRERAERKGRNPQTGKEMTIAASKVPAFKAGKALKDAVK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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