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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 22-NOV-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae gamPNI0373
  • locus tag: HMPREF1038_RS07735 [old locus tag: HMPREF1038_01581 ]
  • pan locus tag?: PNEUPAN002999000
  • symbol: HMPREF1038_RS07735
  • pan gene symbol?: pdxK
  • synonym:
  • product: bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF1038_RS07735 [old locus tag: HMPREF1038_01581 ]
  • symbol: HMPREF1038_RS07735
  • product: bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase
  • replicon: chromosome
  • strand: -
  • coordinates: 1451438..1452211
  • length: 774
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_018630 (1451438..1452211) NCBI
  • BioCyc: HMPREF1038_RS07735 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1423 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGAAGAATAATCGTATTTTAGCACTTTCTGGAAATGATATTTTTAGTGGTGGTGGACTG
    TCGGCTGATTTGGCTACCTATACCTTGAACGACTTGCATGGGTTTGTAGCAGTGACTTGT
    TTGACAGCCTTGACAGAAAAAGGATTTGAAGTCTTTCCAACTGATGATACCATTTTTCAA
    CATGAATTAGATAGCTTGCGTGATGTGGAATTTGGGGGAATTAAGATTGGTCTTCTCCCT
    ACTGTCAGTGTGGCTGAGAAGGCCTTGGACTTTATCAAACAACGCCCAGGAGTATCTGTG
    GTGCTGGATCCTGTCTTGGTCTGCAAGGAAACGCATGATGTAGCTGTCAGTGAGCTCTGC
    CAAGAGTTGATTCGCTTTTTCCCTTATGTCAGTGTGATTACGCCTAATCTCCCAGAAGCA
    GAATTATTATCCGGTCAGGAAATTAAAACCTTGGAAGACATGAAAACTGCAGCGCAGAAA
    TTGCATGATTTAGGAGCGCCAGCAGTCATTATCAAGGGAGGCAATCGTCTTAGTCAGGAC
    AAGGCTGTGGATGTCTTTTATGATGGACAGACCTTTACTATCCTAGAAAATCCAGTTATC
    CAAGGCCAAAATGCTGGTGCAGGTTGTACCTTTGCCTCTAGCATTGCCAGTCACTTGGTT
    AAAGGTGATAAACTTTTGCCAGCAGTAGAAAGTTCTAAGGCTTTCGTTTATCGTGCTATT
    GCACAAGCAGATCAGTATGGAGTAAGACAATATGAAGCAAACAAAAACAACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    774

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF1038_RS07735 [old locus tag: HMPREF1038_01581 ]
  • symbol: HMPREF1038_RS07735
  • description: bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase
  • length: 257
  • theoretical pI: 4.73232
  • theoretical MW: 27759.4
  • GRAVY: 0.0431907

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.4.7?  ExPASy
    Phosphooxymethylpyrimidine kinase ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine = ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
    EC 2.7.1.49?  ExPASy
    Hydroxymethylpyrimidine kinase ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphomethyl)pyrimidine
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase (TIGR00097; EC 2.7.1.49,2.7.4.7; HMM-score: 172.3)
    and 7 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridoxine pyridoxal kinase (TIGR00687; EC 2.7.1.35; HMM-score: 45.9)
    Metabolism Energy metabolism Sugars ribokinase (TIGR02152; EC 2.7.1.15; HMM-score: 45.1)
    hexose kinase, 1-phosphofructokinase family (TIGR03168; EC 2.7.1.-; HMM-score: 26.8)
    1-phosphofructokinase (TIGR03828; EC 2.7.1.56; HMM-score: 25.1)
    Metabolism Energy metabolism Sugars 5-dehydro-2-deoxygluconokinase (TIGR04382; EC 2.7.1.92; HMM-score: 23.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine hydroxyethylthiazole kinase (TIGR00694; EC 2.7.1.50; HMM-score: 19.3)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides bifunctional protein RfaE, domain I (TIGR02198; EC 2.7.1.-; HMM-score: 14.8)
  • TheSEED: see HMPREF1038_01581
  • PFAM:
    Ribokinase (CL0118) Phos_pyr_kin; Phosphomethylpyrimidine kinase (PF08543; HMM-score: 210.5)
    and 2 more
    PfkB; pfkB family carbohydrate kinase (PF00294; HMM-score: 43.3)
    HK; Hydroxyethylthiazole kinase family (PF02110; HMM-score: 16.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9901
    • Cytoplasmic Membrane Score: 0.0033
    • Cell wall & surface Score: 0.0006
    • Extracellular Score: 0.006
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.022695
    • TAT(Tat/SPI): 0.001169
    • LIPO(Sec/SPII): 0.003756
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000794748 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKNNRILALSGNDIFSGGGLSADLATYTLNDLHGFVAVTCLTALTEKGFEVFPTDDTIFQHELDSLRDVEFGGIKIGLLPTVSVAEKALDFIKQRPGVSVVLDPVLVCKETHDVAVSELCQELIRFFPYVSVITPNLPEAELLSGQEIKTLEDMKTAAQKLHDLGAPAVIIKGGNRLSQDKAVDVFYDGQTFTILENPVIQGQNAGAGCTFASSIASHLVKGDKLLPAVESSKAFVYRAIAQADQYGVRQYEANKNN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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