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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 11-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae INV104
  • locus tag: INV104_RS00860 [old locus tag: INV104_01380 ]
  • pan locus tag?: PNEUPAN000884000
  • symbol: INV104_RS00860
  • pan gene symbol?: epiD
  • synonym:
  • product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: INV104_RS00860 [old locus tag: INV104_01380 ]
  • symbol: INV104_RS00860
  • product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase
  • replicon: chromosome
  • strand: +
  • coordinates: 158645..159202
  • length: 558
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017591 (158645..159202) NCBI
  • BioCyc: INV104_RS00860 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGGATAAGAAAAATTTACTTGTATTGGTTACTGGTTCGGTAGGTGCCAGTAATGTAGAT
    ACATACTTATATTATATAAAAAAATTCTATAATGTTAAAGTGATACTTTCTGAAAATTCT
    AAAAAATTTATAAGTAAGGAATTAATTAGTTATTTTTGTGATAAAGTTTATGATGAAATA
    TTTGTTGAAGAGGTAGTTCCGCACGTTTTTCTGCCATATGAATCTGACTTACTTCTTATT
    TTACCAGCTACGGCAAATGTGATTGGCAAAATTGCTAATGGTATTGCTGATGATTTAGTT
    ACAGCAACTGTTTTAAACTTTAATAAAAAAATAATTTTTTGTCCCAATATGAACTCTACT
    ATGTGGGACAATCACATAGTTCAAAGAAATGTATCAATTCTAAAGGAGTTGGGACATATA
    TTTTTATTTGAGTCTAAAAAAACATATGAGGTAGGATTGCGTAAAGCAATAGATTCAACA
    TGTTCAATGTTACAACCACAGTCGTTAGTAAAAGAACTTATCAAATTAGAAAATATTGTC
    CTTGAAGAGGGACATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    558

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: INV104_RS00860 [old locus tag: INV104_01380 ]
  • symbol: INV104_RS00860
  • description: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase
  • length: 185
  • theoretical pI: 6.51353
  • theoretical MW: 21038.5
  • GRAVY: 0.160541

⊟Function[edit | edit source]

  • reaction:
    EC 6.3.2.5?  ExPASy
    Phosphopantothenate--cysteine ligase (CTP) CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine
    EC 4.1.1.36?  ExPASy
    Phosphopantothenoylcysteine decarboxylase N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase (TIGR00521; EC 4.1.1.36,6.3.2.5; HMM-score: 114.5)
    and 5 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A phosphopantothenoylcysteine decarboxylase (TIGR02113; EC 4.1.1.36; HMM-score: 87.1)
    Unknown function General archaeoflavoprotein, MJ0208 family (TIGR02700; HMM-score: 28.7)
    Metabolism Energy metabolism Electron transport archaeoflavoprotein AfpA (TIGR02699; HMM-score: 27)
    Unknown function Enzymes of unknown specificity polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases (TIGR00421; EC 4.1.1.-; HMM-score: 15.3)
    Cellular processes Cellular processes Sporulation and germination dipicolinic acid synthetase, B subunit (TIGR02852; HMM-score: 14.7)
  • TheSEED: see INV104_01380
  • PFAM:
    no clan defined Flavoprotein; Flavoprotein (PF02441; HMM-score: 111.3)
    and 1 more
    NADP_Rossmann (CL0063) Methyltransf_30; S-adenosyl-L-methionine-dependent methyltransferase (PF05430; HMM-score: 11.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.8727
    • Cytoplasmic Membrane Score: 0.0139
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.1134
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.028652
    • TAT(Tat/SPI): 0.000348
    • LIPO(Sec/SPII): 0.024568
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000358739 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MDKKNLLVLVTGSVGASNVDTYLYYIKKFYNVKVILSENSKKFISKELISYFCDKVYDEIFVEEVVPHVFLPYESDLLLILPATANVIGKIANGIADDLVTATVLNFNKKIIFCPNMNSTMWDNHIVQRNVSILKELGHIFLFESKKTYEVGLRKAIDSTCSMLQPQSLVKELIKLENIVLEEGH

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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