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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 11-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae INV104
  • locus tag: INV104_RS02365 [old locus tag: INV104_04060 ]
  • pan locus tag?: PNEUPAN001337000
  • symbol: trkA
  • pan gene symbol?: trkA
  • synonym:
  • product: Trk system potassium transporter TrkA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: INV104_RS02365 [old locus tag: INV104_04060 ]
  • symbol: trkA
  • product: Trk system potassium transporter TrkA
  • replicon: chromosome
  • strand: -
  • coordinates: 452287..453636
  • length: 1350
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017591 (452287..453636) NCBI
  • BioCyc: INV104_RS02365 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0430 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGAAAATTATCCTTGTCGGAGGGGGAAAAGTTGGTTTTGCCCTCTGTCGCTCCTTGGTT
    GCAGAAAAGCATGATGTTTTGCTGATTGAGCAAGACGAAGCTGTTCTCAATCATATTGTC
    AGTCGCTTTGATATCATTGGTATCCTTGGTAACGGGGCCGATTTTGCCATTCTTGAGCAA
    GCCAGCGTCCAAGATTGTGATATCTTTATCGCCCTGACTGAGCACGATGAAGTCAACATG
    ATTGCAGCAGTTCTAGCCAAGAAAATGGGAGCTAAAGAAACTATCGTTCGGGTGCGGAAC
    CCTGAATATTCTAACTCTTATTTCAAGGAAAAGAATATTCTCGGTTTTTCTCTTATCGTT
    AATCCTGAGCTCTTGGCTGCCCGTGCTATCGCGAATATCATTGACTTCCCCAACGCCCTG
    TCTGTCGAACGCTTTGCTGGTGGACGCGTTAGCCTCATGGAATTTGTCGTCAAGTCCACC
    AGCGGTCTTTGCCAAATGCCCATTTCTGATTTTCGTAAAAAATTTGGTAATGTCATTGTC
    TGTGCGATAGAGAGGGATCATCAAATTATCATTCCAAGCGGTGACATGACTGTACAGGAT
    AAAGATAGAATCTTTGTCACTGGTAACCGTGTCGATATGATACTCTTCCATAATTATTTT
    AAATCACGCGCCGTGAAGAGCCTTCTCATCGTTGGGGCAGGTAGAATTGCCTATTATCTA
    CTTGGTATTCTCAAAGATAGTCGTATCGATACAAAAGTCATTGAAATCAATCCTGAAATC
    GCCAGCTTCTTTAGCGAGAAATTCCCAAATCTCTACATCGTTCAAGGAGATGGAACCGCA
    AAAGATATCCTGCTGGAAGAAAGTGCTCAACACTATGATGCCGTTGCGACTCTAACAGGA
    GTCGATGAGGAAAATCTGATTACATCTATGTTCCTTGACAGGGTAGGTGTACAGAAAAAT
    ATTACTAAGGTCAATCGTACCAGTCTCCTCGAGATTATCAATGCGCCTGATTTTTCAAGT
    ATCATCACACCTAAAAGCATCGCTGTAGATACGATTATGCACTTTATTCGTGGTCGAGTT
    AATGCCCAGTATTCAGACCTTCAAGCCATGCACCATCTAGCCAATGGCCAAATCGAAACC
    CTGCAATTCCATATCAAGGAAGCCAATAAAATGACTGCCAAACCTCTTTCTCAACTGAAA
    TTGAAAAAAGGGGTTCTTATTGCAGCCATTATTCGAAAGGGCAAGACTATTTTCCCAACT
    GGGGAGGATATGTTGGAAGTTGGAGACAAGCTCCTAGTAACAACCTTGTTGCCAAACATC
    ACCAAGATTTATGACTTGATTGCGAGGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1350

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: INV104_RS02365 [old locus tag: INV104_04060 ]
  • symbol: TrkA
  • description: Trk system potassium transporter TrkA
  • length: 449
  • theoretical pI: 7.32499
  • theoretical MW: 49773.8
  • GRAVY: 0.177506

⊟Function[edit | edit source]

  • TIGRFAM:
    aspartate-alanine antiporter (TIGR03802; HMM-score: 26)
    and 8 more
    Cellular processes Cellular processes Detoxification CoA-disulfide reductase (TIGR03385; EC 1.8.1.14; HMM-score: 20.2)
    Metabolism Energy metabolism Anaerobic glycerol-3-phosphate dehydrogenase, anaerobic, A subunit (TIGR03377; EC 1.1.5.3; HMM-score: 16.4)
    nucleotide sugar dehydrogenase (TIGR03026; HMM-score: 16.1)
    Genetic information processing Protein fate Protein folding and stabilization xanthine dehydrogenase accessory protein XdhC (TIGR02964; HMM-score: 13.8)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Other xanthine dehydrogenase accessory protein XdhC (TIGR02964; HMM-score: 13.8)
    dihydrolipoyl dehydrogenase (TIGR01350; EC 1.8.1.4; HMM-score: 12.5)
    Metabolism Energy metabolism Pentose phosphate pathway 6-phosphogluconate dehydrogenase (decarboxylating) (TIGR00872; EC 1.1.1.44; HMM-score: 12)
    flavin-dependent oxidoreductase, MSMEG_0569 family (TIGR04046; HMM-score: 10.8)
  • TheSEED: see INV104_04060
  • PFAM:
    NADP_Rossmann (CL0063) TrkA_N; TrkA-N domain (PF02254; HMM-score: 140.1)
    and 11 more
    TrkA_C (CL0582) TrkA_C; TrkA-C domain (PF02080; HMM-score: 87.5)
    NADP_Rossmann (CL0063) NAD_binding_7; Putative NAD(P)-binding (PF13241; HMM-score: 29.4)
    XdhC_C; XdhC Rossmann domain (PF13478; HMM-score: 21.8)
    TrkA_C (CL0582) Castor_Poll_mid; Castor and Pollux, part of voltage-gated ion channel (PF06241; HMM-score: 21.6)
    NADP_Rossmann (CL0063) F420_oxidored; NADP oxidoreductase coenzyme F420-dependent (PF03807; HMM-score: 18.8)
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase (PF00070; HMM-score: 18.6)
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 18.5)
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase (PF03446; HMM-score: 15.2)
    DUF166; Domain of unknown function (PF02593; HMM-score: 14.2)
    HUP (CL0039) UDPG_MGDP_dh_C; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain (PF03720; HMM-score: 13.2)
    NADP_Rossmann (CL0063) NAD_binding_8; NAD(P)-binding Rossmann-like domain (PF13450; HMM-score: 12.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.05
    • Cytoplasmic Membrane Score: 8.78
    • Cellwall Score: 0.08
    • Extracellular Score: 0.09
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.2866
    • Cytoplasmic Membrane Score: 0.5984
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.1148
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.010801
    • TAT(Tat/SPI): 0.000212
    • LIPO(Sec/SPII): 0.002727
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000691685 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKIILVGGGKVGFALCRSLVAEKHDVLLIEQDEAVLNHIVSRFDIIGILGNGADFAILEQASVQDCDIFIALTEHDEVNMIAAVLAKKMGAKETIVRVRNPEYSNSYFKEKNILGFSLIVNPELLAARAIANIIDFPNALSVERFAGGRVSLMEFVVKSTSGLCQMPISDFRKKFGNVIVCAIERDHQIIIPSGDMTVQDKDRIFVTGNRVDMILFHNYFKSRAVKSLLIVGAGRIAYYLLGILKDSRIDTKVIEINPEIASFFSEKFPNLYIVQGDGTAKDILLEESAQHYDAVATLTGVDEENLITSMFLDRVGVQKNITKVNRTSLLEIINAPDFSSIITPKSIAVDTIMHFIRGRVNAQYSDLQAMHHLANGQIETLQFHIKEANKMTAKPLSQLKLKKGVLIAAIIRKGKTIFPTGEDMLEVGDKLLVTTLLPNITKIYDLIAR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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