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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 11-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae INV104
  • locus tag: INV104_RS06140 [old locus tag: INV104_10650 ]
  • pan locus tag?: PNEUPAN002488000
  • symbol: uvrB
  • pan gene symbol?: uvrB
  • synonym:
  • product: excinuclease ABC subunit UvrB

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: INV104_RS06140 [old locus tag: INV104_10650 ]
  • symbol: uvrB
  • product: excinuclease ABC subunit UvrB
  • replicon: chromosome
  • strand: -
  • coordinates: 1168193..1170181
  • length: 1989
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017591 (1168193..1170181) NCBI
  • BioCyc: INV104_RS06140 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1096 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    ATGATCAATCACATTACAGATAATCAATTTAAACTAGTATCAAAATATCAACCATCAGGA
    GATCAACCCCAAGCTATCGAGCAGTTGGTGGATAACATTGAGGGGGGAGAAAAAGCTCAG
    ATTCTGATGGGGGCGACTGGAACAGGGAAGACCTATACTATGAGTCAGGTCATTTCTAAA
    GTCAATAAACCAACTCTGGTTATTGCCCACAATAAAACTCTGGCTGGTCAGCTCTATGGG
    GAGTTTAAGGAATTTTTCCCTGAAAATGCAGTTGAGTATTTCGTATCCTACTATGATTAT
    TACCAGCCAGAGGCCTATGTCCCTTCTAGCGATACCTATATTGAGAAGGATAGTTCTGTC
    AATGACGAGATTGACAAGCTTCGCCACTCAGCTACCTCAGCACTTTTGGAGCGTAATGAT
    GTTATTGTCGTGGCCTCAGTCTCTTGTATCTATGGTTTGGGTTCGCCCAAGGAATACGCT
    GATAGTGTCGTTAGTCTCCGTCCTGGTCTAGAGATTTCTCGTGATAAACTCTTGAATGAC
    TTGGTCGATATTCAGTTTGAACGCAATGATATTGATTTCCAACGCGGAAGATTTCGCGTT
    CGTGGGGATGTGGTAGAGATTTTCCCAGCTTCCCGAGATGAACATGCCTTTCGAGTAGAA
    TTTTTTGGAGACGAAATTGACCGTATTCGTGAAGTTGAGGCTCTGACAGGTCAGGTGTTG
    GGAGAAGTGGATCATTTAGCGATTTTCCCAGCGACACACTTTGTGACCAATGACGACCAT
    ATGGAAGTTGCCATTGCAAAGATTCAGGCCGAGTTGGAAGAACAATTAGCTGTCTTTGAA
    AAGGAAGGTAAACTGCTTGAAGCCCAGCGTTTGAAACAGCGGACAGAGTATGATATCGAA
    ATGTTGCGTGAGATGGGCTATACCAATGGGGTTGAGAACTATTCACGACACATGGATGGA
    CGGAGCGAAGGAGAGCCTCCTTATACGCTCTTAGATTTCTTCCCAGATGATTTCTTAATT
    ATGATTGACGAGAGTCACATGACCATGGGGCAAATCAAGGGCATGTACAATGGAGACCGT
    TCGCGTAAAGAAATGCTGGTTAATTATGGCTTCCGATTGCCGTCTGCTTTGGACAATCGT
    CCTCTCCGTCGGGAGGAGTTTGAGAGTCACGTTCATCAGATTGTTTACGTTTCAGCGACA
    CCTGGTGACTATGAAAATGAACAGACTGAGACAGTGATTGAGCAAATCATTCGTCCAACG
    GGACTCTTGGATCCTGAAGTGGAAGTCCGTCCGACTATGGGACAGATTGATGACCTCTTG
    GGTGAAATCAATGCCCGCATTGAAAAAAATGAGCGTACCTTTATCACAACTTTGACCAAG
    AAAATGGCAGAGGACTTGACCGACTACTTCAAGGAAATGGGTATCAAGGTCAAGTACATG
    CACTCGGATATCAAGACCTTGGAACGGACGGAGATTATCCGTGACCTGCGCTTGGGTGTC
    TTTGATGTCTTGGTCGGAATTAACCTGCTCCGTGAAGGAATTGACGTTCCTGAAGTGAGC
    CTCGTAGCTATTCTCGATGCTGATAAGGAAGGTTTCCTTCGCAACGAACGTGGACTCATC
    CAGACTATTGGACGTGCTGCTCGTAACAGTGAAGGCCATGTCATCATGTATGCAGACACG
    GTTACCCAGTCTATGCAACGTGCTATCGATGAAACTGCCCGCCGTCGGAAAATTCAGATG
    ACCTATAATGAAGAGCATGATATCGTACCACAGACAATCAAGAAAGAAATCCGTGACCTG
    ATTGCCGTGACCAAGGCAGTTGCTAAGGAAGAGGACAAGGAAGTCGACATCAATAGCCTC
    AACAAACAAGAGCGCAAGGAACTCGTCAAGAAACTAGAAAAACAAATGCAAGAAGCCGTC
    GAAGTGCTTGACTTTGAACTGGCGGCTCAGATTCGTGATATGATGTTGGAAGTCAAGGTC
    TTGGATTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    1989

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: INV104_RS06140 [old locus tag: INV104_10650 ]
  • symbol: UvrB
  • description: excinuclease ABC subunit UvrB
  • length: 662
  • theoretical pI: 4.56763
  • theoretical MW: 75881.4
  • GRAVY: -0.451662

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit B (TIGR00631; EC 3.1.25.-; HMM-score: 1110.2)
    and 9 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair transcription-repair coupling factor (TIGR00580; EC 3.6.1.-; HMM-score: 64.2)
    DNA phosphorothioation system restriction enzyme (TIGR04095; HMM-score: 41.7)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair ATP-dependent DNA helicase RecG (TIGR00643; EC 3.6.4.12; HMM-score: 36.2)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair primosomal protein N' (TIGR00595; EC 3.6.1.-; HMM-score: 34)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair ATP-dependent DNA helicase, RecQ family (TIGR00614; EC 3.6.4.12; HMM-score: 19.6)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair ATP-dependent DNA helicase RecQ (TIGR01389; EC 3.6.4.12; HMM-score: 19)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit C (TIGR00194; EC 3.1.25.-; HMM-score: 14.3)
    N-acetyl-ornithine/N-acetyl-lysine deacetylase (TIGR01902; HMM-score: 14)
    helicase/secretion neighborhood putative DEAH-box helicase (TIGR03817; HMM-score: 11.7)
  • TheSEED: see INV104_10650
  • PFAM:
    UB2H (CL0664) UvrB_inter; UvrB interaction domain (PF17757; HMM-score: 118.4)
    and 18 more
    P-loop_NTPase (CL0023) UvrB; Ultra-violet resistance protein B (PF12344; HMM-score: 81)
    Helicase_C; Helicase conserved C-terminal domain (PF00271; HMM-score: 66)
    ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 51.5)
    AAA_lid (CL0671) UVR; UvrB/uvrC motif (PF02151; HMM-score: 40.1)
    P-loop_NTPase (CL0023) DEAD; DEAD/DEAH box helicase (PF00270; HMM-score: 21.5)
    AAA_30; AAA domain (PF13604; HMM-score: 20.8)
    Kinesin; Kinesin motor domain (PF00225; HMM-score: 17.1)
    AAA_7; P-loop containing dynein motor region (PF12775; HMM-score: 15.6)
    Microtub_bd; Microtubule binding (PF16796; HMM-score: 15.1)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 15)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 14.6)
    AAA_19; AAA domain (PF13245; HMM-score: 14.5)
    TypeIII_Chap (CL0097) DUF2299; Uncharacterized conserved protein (DUF2299) (PF10061; HMM-score: 14.2)
    P-loop_NTPase (CL0023) AAA_5; AAA domain (dynein-related subfamily) (PF07728; HMM-score: 13.9)
    AAA_25; AAA domain (PF13481; HMM-score: 13.9)
    AAA_22; AAA domain (PF13401; HMM-score: 13.2)
    HTH (CL0123) HTH_22; HTH domain (PF13309; HMM-score: 10.2)
    no clan defined HetR_C; Heterocyst differentiation regulator C-terminal Hood domain (PF18460; HMM-score: 8.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9763
    • Cytoplasmic Membrane Score: 0.0151
    • Cell wall & surface Score: 0.0004
    • Extracellular Score: 0.0081
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.037394
    • TAT(Tat/SPI): 0.004847
    • LIPO(Sec/SPII): 0.001104
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000607030 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MINHITDNQFKLVSKYQPSGDQPQAIEQLVDNIEGGEKAQILMGATGTGKTYTMSQVISKVNKPTLVIAHNKTLAGQLYGEFKEFFPENAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSALLERNDVIVVASVSCIYGLGSPKEYADSVVSLRPGLEISRDKLLNDLVDIQFERNDIDFQRGRFRVRGDVVEIFPASRDEHAFRVEFFGDEIDRIREVEALTGQVLGEVDHLAIFPATHFVTNDDHMEVAIAKIQAELEEQLAVFEKEGKLLEAQRLKQRTEYDIEMLREMGYTNGVENYSRHMDGRSEGEPPYTLLDFFPDDFLIMIDESHMTMGQIKGMYNGDRSRKEMLVNYGFRLPSALDNRPLRREEFESHVHQIVYVSATPGDYENEQTETVIEQIIRPTGLLDPEVEVRPTMGQIDDLLGEINARIEKNERTFITTLTKKMAEDLTDYFKEMGIKVKYMHSDIKTLERTEIIRDLRLGVFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSEGHVIMYADTVTQSMQRAIDETARRRKIQMTYNEEHDIVPQTIKKEIRDLIAVTKAVAKEEDKEVDINSLNKQERKELVKKLEKQMQEAVEVLDFELAAQIRDMMLEVKVLD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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