From PneumoWiki
Jump to navigation Jump to search
PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 11-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae INV104
  • locus tag: INV104_RS09725 [old locus tag: INV104_16780 ]
  • pan locus tag?: PNEUPAN002155000
  • symbol: INV104_RS09725
  • pan gene symbol?: tprA
  • synonym: plcR
  • product: helix-turn-helix domain-containing protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: INV104_RS09725 [old locus tag: INV104_16780 ]
  • symbol: INV104_RS09725
  • product: helix-turn-helix domain-containing protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1834439..1835209
  • length: 771
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017591 (1834439..1835209) NCBI
  • BioCyc: INV104_RS09725 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1745 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATTAGTAAAATTGAGAGAGGGTATTTCATTCCCTCCGCAGACCTTTTGTTCAAACTCTCA
    CAACGACTCGAAGTGCCATTAGATTATTTTTTTAATGAACAAATTGAAATTAAATCTAAC
    CTCTCTAATTTCAAGCAATTATCTGCTCGCCTATTAGATGATAGAAATTATGAAAATTTG
    GAATATATTTATAGAATAGAGATTGAACGAAGTACTTTTCTAACACTAGAAGACCGAACT
    TACCTTGAATGGATTAAAGCTATTATTGACTTCTGTCAATATGACAGTAAGTGTGAAGCA
    ATTTCTTCATTGGAAAATATATTATTAAAAGTCTCCTCAAATACTTTGATTTATTTAAAG
    GCGTTGAATACTCTATCTAATTTCTATTCCTTAGTGGGTCGTGAACAAGAATATGAGGTA
    AACTACTCTCATTTGATGGAGTTATATCAGACAAAAAATTTTGAGCATCAAGAGTTTTTA
    TTTGGCTACATCAGAGTTCGTTACAATTACGCTCACTACCTAGTATCAAAGGAAAAATAT
    AATGAAGCCATCCAAGAAGCTCTTGAGACTATCGAACTCTGTAAACAAAGACAGACAAGC
    TACCAATTGGCTCCTCTACTTATTCTTGTAGGAAATGCTGGAGCCAAATTTCTAGACAGA
    GAACAAGTCAAAAATTATTATATAGAAGCAAGAGAGCTATGCAAGATTTATAACAATCCT
    TTAATGCTGATGAAGATAGAAAATTATTTGAAGGAATTAGATACTGTTTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    771

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: INV104_RS09725 [old locus tag: INV104_16780 ]
  • symbol: INV104_RS09725
  • description: helix-turn-helix domain-containing protein
  • length: 256
  • theoretical pI: 4.96852
  • theoretical MW: 30619.8
  • GRAVY: -0.333984

⊟Function[edit | edit source]

  • TIGRFAM:
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    HTH (CL0123) HTH_3; Helix-turn-helix (PF01381; HMM-score: 25.8)
    and 4 more
    TPR (CL0020) RNPP_C; RNPP family C-terminal domain (PF18768; HMM-score: 20)
    HTH (CL0123) HTH_19; Helix-turn-helix domain (PF12844; HMM-score: 17.6)
    no clan defined DUF1128; Protein of unknown function (DUF1128) (PF06569; HMM-score: 12.4)
    TPR (CL0020) TPR_10; Tetratricopeptide repeat (PF13374; HMM-score: 7.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.6893
    • Cytoplasmic Membrane Score: 0.2038
    • Cell wall & surface Score: 0.0134
    • Extracellular Score: 0.0935
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001621
    • TAT(Tat/SPI): 0.000164
    • LIPO(Sec/SPII): 0.000227
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_225415938 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSKIERGYFIPSADLLFKLSQRLEVPLDYFFNEQIEIKSNLSNFKQLSARLLDDRNYENLEYIYRIEIERSTFLTLEDRTYLEWIKAIIDFCQYDSKCEAISSLENILLKVSSNTLIYLKALNTLSNFYSLVGREQEYEVNYSHLMELYQTKNFEHQEFLFGYIRVRYNYAHYLVSKEKYNEAIQEALETIELCKQRQTSYQLAPLLILVGNAGAKFLDREQVKNYYIEARELCKIYNNPLMLMKIENYLKELDTV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Sharon E Hoover, Amilcar J Perez, Ho-Ching T Tsui, Dhriti Sinha, David L Smiley, Richard D DiMarchi, Malcolm E Winkler, Beth A Lazazzera
A new quorum-sensing system (TprA/PhrA) for Streptococcus pneumoniae D39 that regulates a lantibiotic biosynthesis gene cluster.
Mol Microbiol: 2015, 97(2);229-43
[PubMed:25869931] [WorldCat.org] [DOI] (I p)

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=INV104_RS09725&oldid=94562"