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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 25-NOV-2024
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae R6
- locus tag: SPR_RS08855 [old locus tag: spr1763 ]
- pan locus tag?: PNEUPAN002155000
- symbol: SPR_RS08855
- pan gene symbol?: tprA
- synonym: plcR
- product: helix-turn-helix domain-containing protein
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SPR_RS08855 [old locus tag: spr1763 ]
- symbol: SPR_RS08855
- product: helix-turn-helix domain-containing protein
- replicon: chromosome
- strand: -
- coordinates: 1730704..1731567
- length: 864
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: NC_003098 (1730704..1731567) NCBI
- BioCyc: see spr1763
- MicrobesOnline: see spr1763
- PneumoBrowse for strain D39V: SPV_1745 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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841ATGAATACACTCGCAGAGAAATTCAGATTGAAAAGAAAAGAGTTGAGACTCTCCCAACAA
ACTCTTGCAGAAGGAATTTGTGAACAAAGCCAGATTAGTAAAATTGAAAGAGGTCATTTT
ATTCCCTCCGCAGACTTGTTATTCAAACTCTCTCAACGACTTGAAGTCCCTTTGGATTAC
TTTTTCAATGAACAAATCGAAGTTAAGTCTAACCTCTCTAATTTCAAACATCTATCTGCT
CGCCTATTAGATGACAGAAATTATGACGATTTAGAATATCTTTATAAAATAGAGGTAGAA
CGAAGCACTTTTCTAACATTAGAAGACCGAACTTACCTTGAATGGATTAAATCTATAATT
GACTTCTATCAATATGACAGTAAGTGTGAGGCAATTTCGTCATTGGAAAATATATTATTA
AAAGTCTCTTCAAATACTCTGATTTATTTAAAGGCGTTGAATACTCTATCTAATTTCTAT
TCCTTAGTGGGTCGTGAACAAGAATATGAGGCAAACTACTCTCATTTAATAGAGTTGTAT
CAGACAAAAAATTTGGACCATCAAGAGTTTTTATTTGGCTACATCAGAGTTCGTTACAAC
TACGCTCACTACCTAGTATCAAAGGAAAAATATAATGAAGCCATCCAAGAAGCTCTTGAA
ACGATTGAACTCTGTAAACAAAGACAGACAAGCTACCAATTGGCTCCTCTACTTATTCTT
GTAGGAAATGCTGGAGCCAAATTTCTAGACAGAGAACAAGTCAAAAATTATTATATAGAA
GCAAGAGAGTTATGTAAGATTTATAACAATCCTTTAATGTTGATGAAGATAGAAAATTAT
TTGAAGGAACTAGATACTGTTTAG60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPR_RS08855 [old locus tag: spr1763 ]
- symbol: SPR_RS08855
- description: helix-turn-helix domain-containing protein
- length: 287
- theoretical pI: 5.4988
- theoretical MW: 34129.8
- GRAVY: -0.404878
⊟Function[edit | edit source]
- TIGRFAM: Regulatory functions DNA interactions transcriptional regulator, y4mF family (TIGR03070; HMM-score: 15.8)Hypothetical proteins Conserved TIGR00270 family protein (TIGR00270; HMM-score: 14.1)
- TheSEED: see spr1763
- PFAM: HTH (CL0123) HTH_3; Helix-turn-helix (PF01381; HMM-score: 48.3)and 7 moreHTH_19; Helix-turn-helix domain (PF12844; HMM-score: 34.5)TPR (CL0020) RNPP_C; RNPP family C-terminal domain (PF18768; HMM-score: 24.8)HTH (CL0123) HTH_31; Helix-turn-helix domain (PF13560; HMM-score: 18.6)no clan defined DUF1128; Protein of unknown function (DUF1128) (PF06569; HMM-score: 15.6)TPR (CL0020) TPR_8; Tetratricopeptide repeat (PF13181; HMM-score: 10.3)TPR_12; Tetratricopeptide repeat (PF13424; HMM-score: 8.8)TPR_10; Tetratricopeptide repeat (PF13374; HMM-score: 8.7)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.7801
- Cytoplasmic Membrane Score: 0.1215
- Cell wall & surface Score: 0.013
- Extracellular Score: 0.0854
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.002619
- TAT(Tat/SPI): 0.000408
- LIPO(Sec/SPII): 0.000571
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MNTLAEKFRLKRKELRLSQQTLAEGICEQSQISKIERGHFIPSADLLFKLSQRLEVPLDYFFNEQIEVKSNLSNFKHLSARLLDDRNYDDLEYLYKIEVERSTFLTLEDRTYLEWIKSIIDFYQYDSKCEAISSLENILLKVSSNTLIYLKALNTLSNFYSLVGREQEYEANYSHLIELYQTKNLDHQEFLFGYIRVRYNYAHYLVSKEKYNEAIQEALETIELCKQRQTSYQLAPLLILVGNAGAKFLDREQVKNYYIEARELCKIYNNPLMLMKIENYLKELDTV
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: no polycistronic organisation predicted
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription[edit | edit source]
- transcription start site:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_1745 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
Sharon E Hoover, Amilcar J Perez, Ho-Ching T Tsui, Dhriti Sinha, David L Smiley, Richard D DiMarchi, Malcolm E Winkler, Beth A Lazazzera
A new quorum-sensing system (TprA/PhrA) for Streptococcus pneumoniae D39 that regulates a lantibiotic biosynthesis gene cluster.
Mol Microbiol: 2015, 97(2);229-43
[PubMed:25869931] [WorldCat.org] [DOI] (I p)