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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

Summary[edit | edit source]

  • organism: Streptococcus pneumoniae INV104
  • locus tag: INV104_RS11335 [old locus tag: INV104_19380 ]
  • pan locus tag?: PNEUPAN003934000
  • symbol: INV104_RS11335
  • pan gene symbol?: comD
  • synonym:
  • product: sensor histidine kinase

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS, pseudogene
  • locus tag: INV104_RS11335 [old locus tag: INV104_19380 ]
  • symbol: INV104_RS11335
  • product: sensor histidine kinase
  • replicon: chromosome
  • strand: -
  • coordinates: 2137694..2139008
  • length: 1315
  • essential: unknown

Accession numbers[edit | edit source]

  • Location: NC_017591 (2137694..2139008) NCBI
  • BioCyc: INV104_RS11335 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_2064 PneumoBrowse

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGGATTTACTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGTTAC
    CGTTTAATTTGTAAAGGTCGAATAAATAGAAAAGAATTATACGTTTTTGGTGCTTATACA
    TTACTAACTGAAATAGTACTTGAATTTTCCTTTTCTCTTCTATATTTAGATAAAATAGGG
    ATTGAAAGATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATGAAACAGTAT
    GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCAT
    AACTTTCTGTCCGTAATTTTCTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCAT
    TTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTGTTACATTAAAAATCATTTAC
    TATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
    GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACG
    ATTAAACATTTGAATAGTTTTGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTT
    TTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGGAGAAAGAGATTGCTTTGAAG
    CAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
    AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCA
    ATTGACAGTGGTAATTTACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATT
    GCGTTCAGATAAGTACACTTACTTTGATTTGAACAACATAGAAGACTCAGCTTTACGAAG
    TTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTTACACTGGAAGT
    AAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGT
    TTTATTGAATAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGC
    AGTTATTAAGATGGAAACTGAAACAGTTATTGTGATTCAGAATTCATGTAAAATGACGAT
    GACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGAAATCGCGGAGT
    CGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGA
    GATGGAAGGCAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1315

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: INV104_RS11335 [old locus tag: INV104_19380 ]
  • symbol: INV104_RS11335
  • description: sensor histidine kinase
  • length:
  • theoretical pI:
  • theoretical MW:
  • GRAVY:

Function[edit | edit source]

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb:
  • SignalP:
  • predicted transmembrane helices (TMHMM):

Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

Protein sequence[edit | edit source]

Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

Expression data[edit | edit source]

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]

O Ween, P Gaustad, L S Håvarstein
Identification of DNA binding sites for ComE, a key regulator of natural competence in Streptococcus pneumoniae.
Mol Microbiol: 1999, 33(4);817-27
[PubMed:10447890] [WorldCat.org] [DOI] (P p)
Bernard Martin, Chantal Granadel, Nathalie Campo, Vincent Hénard, Marc Prudhomme, Jean-Pierre Claverys
Expression and maintenance of ComD-ComE, the two-component signal-transduction system that controls competence of Streptococcus pneumoniae.
Mol Microbiol: 2010, 75(6);1513-28
[PubMed:20180906] [WorldCat.org] [DOI] (I p)
Claudia Trappetti, Luciana Gualdi, Lorenzo Di Meola, Prashant Jain, Cindy C Korir, Paul Edmonds, Francesco Iannelli, Susanna Ricci, Gianni Pozzi, Marco R Oggioni
The impact of the competence quorum sensing system on Streptococcus pneumoniae biofilms varies depending on the experimental model.
BMC Microbiol: 2011, 11;75
[PubMed:21492426] [WorldCat.org] [DOI] (I e)
M S Chandler, D A Morrison
Competence for genetic transformation in Streptococcus pneumoniae: molecular cloning of com, a competence control locus.
J Bacteriol: 1987, 169(5);2005-11
[PubMed:3032904] [WorldCat.org] [DOI] (P p)
L S Håvarstein, G Coomaraswamy, D A Morrison
An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae.
Proc Natl Acad Sci U S A: 1995, 92(24);11140-4
[PubMed:7479953] [WorldCat.org] [DOI] (P p)
E V Pestova, L S Håvarstein, D A Morrison
Regulation of competence for genetic transformation in Streptococcus pneumoniae by an auto-induced peptide pheromone and a two-component regulatory system.
Mol Microbiol: 1996, 21(4);853-62
[PubMed:8878046] [WorldCat.org] [DOI] (P p)
L S Håvarstein, P Gaustad, I F Nes, D A Morrison
Identification of the streptococcal competence-pheromone receptor.
Mol Microbiol: 1996, 21(4);863-9
[PubMed:8878047] [WorldCat.org] [DOI] (P p)