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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 05-OCT-2017

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_00875 [new locus tag: MDRSPN_RS04615 ]
  • pan locus tag?: PNEUPAN002039000
  • symbol: mnmE
  • pan gene symbol?: mnmE
  • synonym:
  • product: tRNA modification GTPase MnmE

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_00875 [new locus tag: MDRSPN_RS04615 ]
  • symbol: mnmE
  • product: tRNA modification GTPase MnmE
  • replicon: chromosome
  • strand: -
  • coordinates: 887388..888761
  • length: 1374
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: AP018391 (887388..888761) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0902 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGATTACACGTGAATTTGATACCATCGCTGCTATCTCTACTCCACTAGGTGAAGGAGCT
    ATTGGTATTGTCCGCCTGAGCGGAACAGACAGTTTTGCTATTGCGCAAAAGATTTTTAAA
    GGAAAAGACTTGAACAAGGTTGCCAGCCACACTCTCAACTACGGTCACATTATTGATCCT
    CTGACTGGTAAAGTCATGGACGAGGTTATGGTTGGGGCTATGAAGTCTCCAAAGACCTTC
    ACTCGTGAGGATATTATCGAGATTAACACCCACGGTGGTATTGCGGTGACCAATGAGATT
    CTCCAGCTAGCTATCCGTGAAGGAGCTCGGTTGGCAGAACCTGGTGAATTTACCAAACGT
    GCCTTTTTAAACGGTCGCGTAGATTTGACACAGGCCGAGGCGGTGATGGATATCATCCGA
    GCCAAGACAGACAAGGCCATGAACATCGCGGTCAAACAACTTGATGGTTCCCTTTCTGAT
    CTTATCAATAATATCCGTCAAGAAATCCTTAACACACTTGCCCAAGTTGAGGTCAATATC
    GACTATCCTGAGTATGACGATGTTGAGGAAGCCACTACTGCTGTTGTCCGAGAGAAGACA
    ATGGAGTTTGAGCAATTACTAACCAAGCTCCTTAGGACAGCACGTCGTGGTAAAATCCTT
    CGTGAAGGAATTTCAACGGCTATCATTGGACGTCCCAACGTTGGGAAATCAAGCCTTCTC
    AACAACCTCTTGCGTGAGGACAAGGCTATCGTAACAGATATCGCTGGGACAACACGAGAT
    GTCATCGAAGAGTACGTCAACATCAATGGTGTACCTCTCAAATTGATTGATACAGCCGGT
    ATTCGTGAAACAGATGACATAGTGGAACAAATCGGTGTTGAGCGTTCGAAAAAAGCCCTC
    AAGGAAGCCGACTTGGTTCTACTAGTGCTAAATGCCAGTGAACCACTGACTGCGCAAGAC
    AGACAACTTCTTGAAATTAGCCAAGATACCAATCGCATTATTCTACTTAATAAAACCGAC
    CTGCCAGAAACGATTGAAACTTCGAAACTACCTGAAGACGTTATCCGTATTTCAGTCCTT
    AAAAACCAAAACATCGATAAGATTGAAGAGCGAATCAACAACCTCTTCTTTGAAAATGCT
    GGTTTGGTTGAGCAAGATGCTACCTACTTGTCAAACGCCCGTCACATTTCCTTGATTGAG
    AAGGCCGTTGAAAGCCTACAAGCTGTTAACCAAGGTCTTGAACTAGGGATGCCAGTTGAC
    TTGCTTCAAGTTGACTTGACCCGTACTTGGGAAATTCTAGGAGAAATCACTGGAGATGCT
    GCTCCAGATGAACTCATCACCCAACTCTTTAGCCAATTCTGTTTAGGAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1374

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_00875 [new locus tag: MDRSPN_RS04615 ]
  • symbol: MnmE
  • description: tRNA modification GTPase MnmE
  • length: 457
  • theoretical pI: 4.53183
  • theoretical MW: 50515.5
  • GRAVY: -0.109409

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA modification GTPase TrmE (TIGR00450; EC 3.6.-.-; HMM-score: 436.7)
    and 14 more
    Genetic information processing Protein synthesis Other ribosome-associated GTPase EngA (TIGR03594; HMM-score: 131.7)
    Unknown function General small GTP-binding protein domain (TIGR00231; HMM-score: 91.9)
    Genetic information processing Protein fate Protein modification and repair [FeFe] hydrogenase H-cluster maturation GTPase HydF (TIGR03918; HMM-score: 91.3)
    Genetic information processing Protein synthesis Other GTP-binding protein Era (TIGR00436; HMM-score: 65.5)
    Genetic information processing Protein synthesis Other ribosome biogenesis GTP-binding protein YlqF (TIGR03596; HMM-score: 61.1)
    Metabolism Transport and binding proteins Cations and iron carrying compounds ferrous iron transport protein B (TIGR00437; HMM-score: 49.6)
    Genetic information processing Protein synthesis Other ribosome biogenesis GTPase YqeH (TIGR03597; HMM-score: 34.1)
    Unknown function General GTP-binding protein HflX (TIGR03156; HMM-score: 29.7)
    Genetic information processing Protein synthesis Other ribosome biogenesis GTP-binding protein YsxC (TIGR03598; HMM-score: 28.8)
    Genetic information processing Protein synthesis Translation factors ribosome small subunit-dependent GTPase A (TIGR00157; EC 3.6.-.-; HMM-score: 20.1)
    Metabolism Transport and binding proteins Amino acids, peptides and amines chloroplast protein import component Toc86/159, G and M domains (TIGR00993; HMM-score: 17.8)
    Metabolism Energy metabolism Amino acids and amines ethanolamine utilization protein, EutP (TIGR02528; HMM-score: 14.5)
    Genetic information processing Protein synthesis Other Obg family GTPase CgtA (TIGR02729; HMM-score: 13.9)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions guanylate kinase (TIGR03263; EC 2.7.4.8; HMM-score: 12.9)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    no clan defined MnmE_helical; MnmE helical domain (PF12631; HMM-score: 195.8)
    and 12 more
    FBD (CL0289) TrmE_N; GTP-binding protein TrmE N-terminus (PF10396; HMM-score: 140.3)
    P-loop_NTPase (CL0023) MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 93.9)
    FeoB_N; Ferrous iron transport protein B (PF02421; HMM-score: 37.8)
    Dynamin_N; Dynamin family (PF00350; HMM-score: 35)
    AIG1; AIG1 family (PF04548; HMM-score: 28.2)
    GTP_EFTU; Elongation factor Tu GTP binding domain (PF00009; HMM-score: 26.1)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 25.8)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 17.9)
    Ras; Ras family (PF00071; HMM-score: 16.9)
    no clan defined MMR_HSR1_Xtn; C-terminal region of MMR_HSR1 domain (PF16897; HMM-score: 14.3)
    P-loop_NTPase (CL0023) Roc; Ras of Complex, Roc, domain of DAPkinase (PF08477; HMM-score: 14.2)
    ABC_tran; ABC transporter (PF00005; HMM-score: 12.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9945
    • Cytoplasmic Membrane Score: 0.0033
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0021
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.018112
    • TAT(Tat/SPI): 0.015088
    • LIPO(Sec/SPII): 0.00266
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: BBA59078 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MITREFDTIAAISTPLGEGAIGIVRLSGTDSFAIAQKIFKGKDLNKVASHTLNYGHIIDPLTGKVMDEVMVGAMKSPKTFTREDIIEINTHGGIAVTNEILQLAIREGARLAEPGEFTKRAFLNGRVDLTQAEAVMDIIRAKTDKAMNIAVKQLDGSLSDLINNIRQEILNTLAQVEVNIDYPEYDDVEEATTAVVREKTMEFEQLLTKLLRTARRGKILREGISTAIIGRPNVGKSSLLNNLLREDKAIVTDIAGTTRDVIEEYVNINGVPLKLIDTAGIRETDDIVEQIGVERSKKALKEADLVLLVLNASEPLTAQDRQLLEISQDTNRIILLNKTDLPETIETSKLPEDVIRISVLKNQNIDKIEERINNLFFENAGLVEQDATYLSNARHISLIEKAVESLQAVNQGLELGMPVDLLQVDLTRTWEILGEITGDAAPDELITQLFSQFCLGK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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