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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 05-OCT-2017

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_01064 [new locus tag: MDRSPN_RS05590 ]
  • pan locus tag?: PNEUPAN001936000
  • symbol: lytD
  • pan gene symbol?: cbpE
  • synonym:
  • product: choline-binding protein E

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_01064 [new locus tag: MDRSPN_RS05590 ]
  • symbol: lytD
  • product: choline-binding protein E
  • replicon: chromosome
  • strand: -
  • coordinates: 1079921..1081804
  • length: 1884
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: AP018391 (1079921..1081804) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0821 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    ATGAAAAAGAAATTAACTAGTTTAGCACTTGTAGGCGCTTTTTTAGGTTTGTCATGGTAT
    GGGAATGTTCAGGCTCAAGAAAGTTCAGGAAATAAAATCCACTTTATCAATGTTCAAGAA
    GGTGGCAGTGATGCGATTATTCTTGAAAGCAATGGACATTTTGCCATGGTGGATACAGGA
    GAAGATTATGATTTCCCAGATGGAAGTGATTCTCGTTACCCATGGAGAGAAGGAATTGAA
    ACATCTTATAAGCATGTTCTGACAGATCGTGTTTCGCGACATTTAAAGGAATTGGGTGTC
    CAAAAACTTGATTTTATTTTGGTAACCCATACCCATAGTGACCATATTGGAAACGTTGAT
    GAGTTACTGCAAACCTATCCAGTTGGTCGTATCTACATGAAAAAATACTCTGATAGTCGG
    ATTACAACACCAACTCATCTATGGGATAATCTGTATGGCTATGATAAGGTTTTACAGACT
    GCTGCAGAAAAAGGTGTTTCAGTTATTCAAAACATTACACAAGGAGATGCTCATTTTCAG
    TTTGGGGACATGGATATTCAACTCTATAACTATGAAAATGAAACTGATTCATCAGGTGAA
    TTAAAGAAAATTTGGGATGACAATTCTAATTCTTTGATTAGTGTAGTGAAAGTCAATGGT
    AAGAAAATTTACCTCGGAGGAGATTTGGATAATGCTCATGGAGCAGAAGACAAGTATGGT
    CCTCTCATTGGAAAAGTTGATTTGATGAAGTTTAATCATCACTATGATACCAATAAATCA
    AACACCAAGGATTTCATTAAAAATTTGAGTCCGAGTTTGATTGTTCAAACTTCGGATAGT
    TTACCTTGGAAAAATGGTGTTGATAGTGAGTATGTCAATTGGCTCAAAGAACGAGGAATT
    GAGAGAATTAACGCAGCCAGCAAAGACTATGATGCGACAGTTTTTGATATTCGACAAGAT
    GGTTTTGTCAATATTTCAACTTCTTACAAGCAGATTCCAAGTTTTCAAGCTGGTTGGCAT
    AAGAGTGGTTATGGAAACTGGTGGTATCAAGCGCCTGACTCTACAGGAGAATATGCAGTT
    GGTTGGAATGAAATCAAGGGTGAATGGTATTACTTCAACCAAACGGGTATCTTGTTACAG
    AATCAATGGAAAAAATGGAACAATCGTTGGTTCTATTTGACAGACTCTGGTGCATCTGCT
    AAAAATTGGAAGAAAATCAATGGAAGCTGGTATTATTTCAACAAAGAAAATCAGATGGAG
    ACTGGTTGGCTTAATACTGGCGGTCAGACCTATTATCTATCAAATGATGGGGATATGATA
    ACAGGATGGCGTAAGATTGATGGACAATGGTACTATTTTGCTCAATCAGGGGAAATGAAA
    ACGAGCTGGGTAAAAGATAAAGAAACCTGGTACTATATGGATTCTACTGGTACCATGAAG
    ACAGGCGAGATAGAAGTTTCTGGTCATCATTACTATCTAGAAGAATCAGGAGCTATGAAG
    CAAGGCTGGCTTAAAAAGGCAAATGATTGGTATTTCTACAAGACAGATGGTTCACGAGCT
    ATAGGTTGGATTAAAGACAAGGATAAATGGTACTTCTTGAAAGAAAATGGTCAATTACTT
    GTGAATGGTAAGACACCAGAAGGCTATACTGTTGATTCAAGTGGTGCCTGGTTAGTGGAT
    GTTCCGGTAGAGAAATCTGCTACAACTAGAGATACAAGTAACTCAGAAATAAAAGAATCC
    AATGAAGTAGTGAAAAAAGATCTTGAAAATAAAGAAACGAGTCAACACGAAAGTATTACA
    AGTTCTTCAACTAGTCAAGATTTGACTTCTTCAACTTCACAAAGCTCTGAAACGAGTGCA
    AATAAATCGGAATCAGAACAGTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1884

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_01064 [new locus tag: MDRSPN_RS05590 ]
  • symbol: LytD
  • description: choline-binding protein E
  • length: 627
  • theoretical pI: 5.3166
  • theoretical MW: 71648.5
  • GRAVY: -0.792663

⊟Function[edit | edit source]

  • TIGRFAM:
    glucan-binding repeat (TIGR04035; HMM-score: 67)
    and 5 more
    Cellular processes Cellular processes DNA transformation DNA internalization-related competence protein ComEC/Rec2 (TIGR00361; HMM-score: 51.9)
    Cellular processes Cellular processes Detoxification hydroxyacylglutathione hydrolase (TIGR03413; EC 3.1.2.6; HMM-score: 24.9)
    Genetic information processing Transcription Degradation of RNA beta-CASP ribonuclease, RNase J family (TIGR00649; EC 3.1.-.-; HMM-score: 18.9)
    Genetic information processing Transcription RNA processing ribonuclease Z (TIGR02651; EC 3.1.26.11; HMM-score: 16.7)
    arCOG00543 universal archaeal KH-domain/beta-lactamase-domain protein (TIGR03675; HMM-score: 13.7)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    Choline_binding (CL0694) Choline_bind_3; Choline-binding repeat (PF19127; HMM-score: 117.4)
    Choline_bind_1; Putative cell wall binding repeat (PF01473; HMM-score: 104.4)
    and 4 more
    Metallo-HOrase (CL0381) Lactamase_B; Metallo-beta-lactamase superfamily (PF00753; HMM-score: 44.8)
    Choline_binding (CL0694) Choline_bind_2; Choline-binding repeat (PF19085; HMM-score: 28)
    Metallo-HOrase (CL0381) Lactamase_B_2; Beta-lactamase superfamily domain (PF12706; HMM-score: 26.9)
    Lactamase_B_3; Beta-lactamase superfamily domain (PF13483; HMM-score: 17)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Extracellular
    • Cytoplasmic Score: 0.01
    • Cytoplasmic Membrane Score: 0.09
    • Cellwall Score: 0.18
    • Extracellular Score: 9.72
    • Internal Helices: 0
  • SignalP: Signal peptide SP(Sec/SPI) length 25 aa
    • SP(Sec/SPI): 0.997632
    • TAT(Tat/SPI): 0.000347
    • LIPO(Sec/SPII): 0.001191
    • Cleavage Site: CS pos: 25-26. VQA-QE. Pr: 0.9886
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: BBA59267 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKKKLTSLALVGAFLGLSWYGNVQAQESSGNKIHFINVQEGGSDAIILESNGHFAMVDTGEDYDFPDGSDSRYPWREGIETSYKHVLTDRVSRHLKELGVQKLDFILVTHTHSDHIGNVDELLQTYPVGRIYMKKYSDSRITTPTHLWDNLYGYDKVLQTAAEKGVSVIQNITQGDAHFQFGDMDIQLYNYENETDSSGELKKIWDDNSNSLISVVKVNGKKIYLGGDLDNAHGAEDKYGPLIGKVDLMKFNHHYDTNKSNTKDFIKNLSPSLIVQTSDSLPWKNGVDSEYVNWLKERGIERINAASKDYDATVFDIRQDGFVNISTSYKQIPSFQAGWHKSGYGNWWYQAPDSTGEYAVGWNEIKGEWYYFNQTGILLQNQWKKWNNRWFYLTDSGASAKNWKKINGSWYYFNKENQMETGWLNTGGQTYYLSNDGDMITGWRKIDGQWYYFAQSGEMKTSWVKDKETWYYMDSTGTMKTGEIEVSGHHYYLEESGAMKQGWLKKANDWYFYKTDGSRAIGWIKDKDKWYFLKENGQLLVNGKTPEGYTVDSSGAWLVDVPVEKSATTRDTSNSEIKESNEVVKKDLENKETSQHESITSSSTSQDLTSSTSQSSETSANKSESEQ

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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