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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 05-OCT-2017

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_01096 [new locus tag: MDRSPN_RS05780 ]
  • pan locus tag?: PNEUPAN001892000
  • symbol: pfkA
  • pan gene symbol?: pfkA
  • synonym:
  • product: ATP-dependent 6-phosphofructokinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_01096 [new locus tag: MDRSPN_RS05780 ]
  • symbol: pfkA
  • product: ATP-dependent 6-phosphofructokinase
  • replicon: chromosome
  • strand: -
  • coordinates: 1112658..1113665
  • length: 1008
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: AP018391 (1112658..1113665) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0789 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGAAACGTATTGCTGTTTTGACTAGTGGCGGAGACGCACCTGGTATGAACGCTGCCATC
    CGTGCAGTTGTTCGTCAAGCAATTTCAGAAGGAATGGAAGTGTTTGGTATCTATGACGGA
    TATGCTGGTATGGTTGCCGGTGAAATTCATCCCCTAGATGCAGCTTCAGTAGGGGACATC
    ATTTCTCGTGGTGGTACTTTTCTTCACTCAGCTCGTTATCCAGAGTTCGCTCAACTTGAA
    GGGCAACTTAAAGGGATTGAGCAATTGAAAAAACACGGAATTGAAGGTGTAGTTGTTATC
    GGTGGTGACGGATCTTACCACGGCGCTATGCGTTTGACTGAACATGGCTTCCCAGCTATT
    GGTCTTCCAGGTACAATCGATAACGATATCGTTGGTACTGACTTTACAATCGGTTTTGAC
    ACAGCGGTTACTACTGCCATGGACGCTATCGATAAGATTCGTGATACATCATCAAGTCAC
    CGTCGTACTTTTGTAATCGAAGTTATGGGACGTAACGCTGGTGATATCGCTCTTTGGGCT
    GGTATTGCAACTGGTGCTGATGAAATCATCATCCCTGAAGCAGGCTTCAAGATGGAAGAT
    ATCGTAGCAAGCATCAAAGCTGGTTATGAATGTGGTAAAAAACACAATATCATCGTCTTA
    GCTGAAGGTGTGATGTCAGCGGCTGAATTTGGTCAAAAACTTAAAGAAGCTGGAGATACA
    AGCGACCTTCGTGTAACAGAACTTGGACATATTCAACGTGGTGGTTCTCCAACTGCGCGT
    GACCGTGTTTTGGCGTCACGTATGGGTGCACATGCTGTTAAACTTCTTAAAGAAGGTATC
    GGTGGTGTTGCGGTTGGTATTCGTAACGAAAAAATGGTTGAAAATCCAATTCTTGGTACT
    GCAGAAGAAGGGGCATTGTTTAGCCTTACTGCAGAAGGTAAGATTGTGGTTAACAACCCG
    CACAAAGCCGATATTGAGCTATCTAGCTTGAATAAGAGCTTGTCATAA
    60
    120
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    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1008

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_01096 [new locus tag: MDRSPN_RS05780 ]
  • symbol: PfkA
  • description: ATP-dependent 6-phosphofructokinase
  • length: 335
  • theoretical pI: 5.59927
  • theoretical MW: 35173.9
  • GRAVY: 0.0238806

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Energy metabolism Glycolysis/gluconeogenesis 6-phosphofructokinase (TIGR02482; EC 2.7.1.11; HMM-score: 414.1)
    and 3 more
    Metabolism Energy metabolism Glycolysis/gluconeogenesis phosphofructokinase (TIGR02483; HMM-score: 308.1)
    6-phosphofructokinase (TIGR02478; EC 2.7.1.11; HMM-score: 273.8)
    Metabolism Energy metabolism Glycolysis/gluconeogenesis diphosphate--fructose-6-phosphate 1-phosphotransferase (TIGR02477; EC 2.7.1.90; HMM-score: 74.6)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    PFK (CL0240) PFK; Phosphofructokinase (PF00365; HMM-score: 354.1)
    and 2 more
    NAD_kinase; ATP-NAD kinase N-terminal domain (PF01513; HMM-score: 16.4)
    Periplas_BP (CL0144) Peripla_BP_1; Periplasmic binding proteins and sugar binding domain of LacI family (PF00532; HMM-score: 12.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.020315
    • TAT(Tat/SPI): 0.000856
    • LIPO(Sec/SPII): 0.001981
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: BBA59299 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKRIAVLTSGGDAPGMNAAIRAVVRQAISEGMEVFGIYDGYAGMVAGEIHPLDAASVGDIISRGGTFLHSARYPEFAQLEGQLKGIEQLKKHGIEGVVVIGGDGSYHGAMRLTEHGFPAIGLPGTIDNDIVGTDFTIGFDTAVTTAMDAIDKIRDTSSSHRRTFVIEVMGRNAGDIALWAGIATGADEIIIPEAGFKMEDIVASIKAGYECGKKHNIIVLAEGVMSAAEFGQKLKEAGDTSDLRVTELGHIQRGGSPTARDRVLASRMGAHAVKLLKEGIGGVAVGIRNEKMVENPILGTAEEGALFSLTAEGKIVVNNPHKADIELSSLNKSLS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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