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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_RS01995 [old locus tag: MDRSPN_00372 ]
  • pan locus tag?: PNEUPAN001285000
  • symbol: MDRSPN_RS01995
  • pan gene symbol?: fabT
  • synonym:
  • product: MarR family transcriptional regulator

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_RS01995 [old locus tag: MDRSPN_00372 ]
  • symbol: MDRSPN_RS01995
  • product: MarR family transcriptional regulator
  • replicon: chromosome
  • strand: +
  • coordinates: 371737..372171
  • length: 435
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018391 (371737..372171) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0379 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    ATGGACTACCAACGAATCAATGAATATTTAACATCTATATTTAACAATGTCCTTGTAATT
    GAGGAAGTGAACTTGAGAGGTAGTCGTTTTAAGGATATCTCCATCAAAGAAATGCATACG
    ATTGATGTCATCGGTAAGGCTCCAGATGTGACTCCAAGTCAAGTGTCAAAAGAGTTGATG
    GTAACTCTTGGAACTGTTACGACAAGTTTGAACAATTTAGAGCGTAAGGGCTACATTGAG
    CGAGTTCGGTCAGAACAGGATCGTCGTGTGGTGCATCTGCATTTGACAAAGAAGGGTCAC
    TTGATTCATAGACTGCATAAACGCTTCCACAAGGCCATGGTAGAAAAAATTATTGATGGC
    ATGAGCGAGGAAGAAATTGCTGTCATGGGTAAAGGCTTGACTAATCTTTACCAATTTTTG
    GAGGATTTGAAATAA
    60
    120
    180
    240
    300
    360
    420
    435

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_RS01995 [old locus tag: MDRSPN_00372 ]
  • symbol: MDRSPN_RS01995
  • description: MarR family transcriptional regulator
  • length: 144
  • theoretical pI: 9.40494
  • theoretical MW: 16716.3
  • GRAVY: -0.370833

⊟Function[edit | edit source]

  • TIGRFAM:
    mobile rSAM pair MarR family regulator (TIGR04472; HMM-score: 40)
    and 8 more
    homoprotocatechuate degradation operon regulator, HpaR (TIGR02337; HMM-score: 31.5)
    Signal transduction Regulatory functions DNA interactions staphylococcal accessory regulator family (TIGR01889; HMM-score: 26.6)
    EPS-associated transcriptional regulator, MarR family (TIGR04176; HMM-score: 17.8)
    Signal transduction Regulatory functions DNA interactions transcriptional regulator, Acidobacterial, PadR-family (TIGR03433; HMM-score: 17.7)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair repressor LexA (TIGR00498; EC 3.4.21.88; HMM-score: 13.5)
    Signal transduction Regulatory functions DNA interactions repressor LexA (TIGR00498; EC 3.4.21.88; HMM-score: 13.5)
    Cellular processes Cellular processes Toxin production and resistance type 2 lantibiotic, SP_1948 family (TIGR03893; HMM-score: 13.4)
    CRISPR-associated protein Cas4/Csa1, subtype I-A/APERN (TIGR01896; HMM-score: 12.2)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    HTH (CL0123) MarR; MarR family (PF01047; HMM-score: 44)
    MarR_2; MarR family (PF12802; HMM-score: 40.2)
    and 17 more
    HTH_27; Winged helix DNA-binding domain (PF13463; HMM-score: 32.1)
    HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 26.2)
    HTH_34; Winged helix DNA-binding domain (PF13601; HMM-score: 25.8)
    Penicillinase_R; Penicillinase repressor (PF03965; HMM-score: 22.3)
    Fe_dep_repress; Iron dependent repressor, N-terminal DNA binding domain (PF01325; HMM-score: 22.2)
    TrmB; Sugar-specific transcriptional regulator TrmB (PF01978; HMM-score: 20.4)
    HTH_20; Helix-turn-helix domain (PF12840; HMM-score: 15.8)
    PadR; Transcriptional regulator PadR-like family (PF03551; HMM-score: 15.4)
    no clan defined DNA_pol3_a_NI; DNA polymerase III polC-type N-terminus I (PF14480; HMM-score: 15.3)
    HTH (CL0123) Ribosomal_S25; S25 ribosomal protein (PF03297; HMM-score: 14.5)
    LexA_DNA_bind; LexA DNA binding domain (PF01726; HMM-score: 14.4)
    GntR; Bacterial regulatory proteins, gntR family (PF00392; HMM-score: 14.2)
    HxlR; HxlR-like helix-turn-helix (PF01638; HMM-score: 14)
    Replic_Relax; Replication-relaxation (PF13814; HMM-score: 13.7)
    HTH_IclR; IclR helix-turn-helix domain (PF09339; HMM-score: 13.6)
    TFIIE_alpha; TFIIE alpha subunit (PF02002; HMM-score: 13.5)
    HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 13.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by FabT*, TF important in Fatty acid biosynthesis: in TIGR4

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.009261
    • TAT(Tat/SPI): 0.00016
    • LIPO(Sec/SPII): 0.000495
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000386346 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MDYQRINEYLTSIFNNVLVIEEVNLRGSRFKDISIKEMHTIDVIGKAPDVTPSQVSKELMVTLGTVTTSLNNLERKGYIERVRSEQDRRVVHLHLTKKGHLIHRLHKRFHKAMVEKIIDGMSEEEIAVMGKGLTNLYQFLEDLK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Ying-Jie Lu, Charles O Rock
Transcriptional regulation of fatty acid biosynthesis in Streptococcus pneumoniae.
Mol Microbiol: 2006, 59(2);551-66
[PubMed:16390449] [WorldCat.org] [DOI] (P p)

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