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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_RS02635 [old locus tag: MDRSPN_00489 ]
  • pan locus tag?: PNEUPAN003104000
  • symbol: secA
  • pan gene symbol?: secA
  • synonym:
  • product: preprotein translocase subunit SecA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_RS02635 [old locus tag: MDRSPN_00489 ]
  • symbol: secA
  • product: preprotein translocase subunit SecA
  • replicon: chromosome
  • strand: +
  • coordinates: 495844..498357
  • length: 2514
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018391 (495844..498357) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1512 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    ATGGCTAATATTTTAAAAACAATTATCGAAAATGATAAAGGAGAAATCCGTCGTCTGGAA
    AAGATGGCTGACAAGGTTTTCAAATACGAAGACCAAATGGCTGCTTTGACTGACGACCAA
    CTAAAAGCAAAAACAGTTGAATTTAAGGAACGTTATCAAAATGGAGAATCACTGGATTCA
    TTGCTTTACGAAGCATTTGCGGTTGTCCGTGAAGGTGCCAAACGTGTCCTAGGTCTCTTC
    CCTTATAAGGTTCAGGTCATGGGGGGGATTGTTCTTCACCATGGTGACGTGCCAGAGATG
    CGTACAGGGGAAGGGAAAACCTTGACTGCGACCATGCCGGTATACCTCAATGCCCTTTCA
    GGTAAAGGGGTTCACGTAGTTACGGTTAATGAATACCTGTCAGAACGTGACGCGACTGAG
    ATGGGTGAATTGTACTCTTGGCTTGGTTTGTCAGTAGGGATTAACTTGGCTACCAAATCT
    CCAATGGAGAAAAAAGAAGCCTATGAGTGTGATATTACTTACTCAACTAACTCAGAAATC
    GGATTTGACTACCTTCGTGACAATATGGTCGTTCGCGCTGAAAACATGGTACAACGTCCG
    CTTAACTATGCCTTGGTCGATGAGGTTGACTCTATCTTGATTGACGAGGCTCGTACACCT
    TTGATTGTATCAGGTGCCAATGCGGTTGAAACCAGTCAGTTGTATCACATGGCAGACCAC
    TATGTAAAATCTTTGAACAAAGATGACTACATCATCGATGTGCAGTCTAAGACTATTGGT
    TTGTCTGATTCAGGGATTGACAGGGCTGAAAGCTACTTCAAACTTGAAAACCTCTATGAC
    ATCGAAAACGTGGCTTTGACCCACTTTATCGATAACGCCCTTCGTGCCAACTACATCATG
    CTTCTCGATATTGACTATGTGGTGAGCGAAGAGCAAGAAATCTTGATTGTCGACCAATTT
    ACAGGTCGTACCATGGAAGGTCGTCGTTATTCTGATGGATTGCACCAAGCTATTGAAGCC
    AAAGAAGGTGTGCCAATCCAGGATGAAACCAAGACATCTGCCTCAATCACGTACCAAAAC
    CTTTTCCGTATGTACAAAAAATTGTCTGGTATGACGGGTACAGGTAAGACTGAGGAAGAA
    GAATTTCGTGAAATCTACAACATTCGTGTTATTCCAATCCCAACAAACCGTCCTGTTCAA
    CGTATTGACCACTCAGACCTTCTTTATGCAAGTATCGAATCTAAGTTTAAAGCGGTTGTC
    GAAGACGTTAAGGCTCGTTACCAAAAGGGTCAACCTGTCTTGGTTGGTACAGTAGCGGTT
    GAAACTAGTGACTACATTTCTAAGAAATTGGTCGCAGCTGGTGTTCCTCACGAAGTCTTG
    AATGCCAAAAACCACTATAGAGAAGCCCAAATCATCATGAATGCTGGTCAACGTGGTGCC
    GTTACCATCGCAACCAACATGGCGGGTCGTGGTACCGACATCAAGCTTGGTGAAGGTGTT
    CGTGAACTTGGAGGACTTTGTGTTATTGGTACAGAACGTCATGAAAGTCGTCGTATCGAT
    AACCAGCTTCGTGGACGTTCAGGTCGTCAAGGAGATCCAGGTGAGTCACAATTCTACCTA
    TCTCTTGAAGATGATTTGATGAAACGTTTTGGTTCTGAACGCTTGAAGGGAATCTTTGAA
    CGCTTGAACATGTCTGAAGAGGCGATTGAGTCTCGCATGTTGACGCGTCAGGTTGAAGCA
    GCTCAGAAACGTGTCGAAGGAAATAACTACGATACCCGTAAACAAGTCCTTCAATACGAT
    GATGTCATGCGTGAACAACGTGAGATTATCTATGCTCAACGTTACGATGTCATCACTGCA
    GATCGTGACTTGGCACCTGAAATTCAGTCTATGATTAAGCGCACGATTGAACGTGTCGTT
    GATGGTCATGCGCGTGCCAAACAAGATGAAAAACTAGAGGCAATTTTGAACTTTGCTAAG
    TACAACTTGCTTCCTGAAGATTCTATTACGATGGAAGACTTGTCAGGCTTGTCTGATAAG
    GCCATCAAGGAAGAGCTTTTCCAACGTGCCTTGAAGGTTTACGATAGTCAGGTTTCAAAA
    CTACGCGATGAAGAAGCAGTTAAAGAATTCCAAAAAGTTTTGATTCTACGAGTGGTGGAT
    AACAAGTGGACAGATCATATCGCTGCCCTTGATCAATTGCGTAACGCGGTTGGACTTCGT
    GGCTATGCTCAGAACAACCCTGTTGTTGAGTATCAGGCAGAAGGTTTCCGTATGTTTAAT
    GATATGATTGGTTCGATTGAGTTTGATGTGACACGCTTGATGATGAAAGCACAAATTCAT
    GAACAAGAAAGACCACAGGCAGAACGTCATATCAGTACAACAGCGACTCGCAATATCGCT
    GCTCACCAAGCAAGTATGCCAGAAGATTTGGATTTGAGCCAGATTGGACGCAATGAACTT
    TGCCCATGTGGTTCTGGTAAGAAATTTAAAAACTGTCACGGTAAAAGAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2514

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_RS02635 [old locus tag: MDRSPN_00489 ]
  • symbol: SecA
  • description: preprotein translocase subunit SecA
  • length: 837
  • theoretical pI: 5.34408
  • theoretical MW: 94985.2
  • GRAVY: -0.482079

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein fate Protein and peptide secretion and trafficking preprotein translocase, SecA subunit (TIGR00963; HMM-score: 1043.1)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking accessory Sec system translocase SecA2 (TIGR04397; HMM-score: 913.1)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking accessory Sec system translocase SecA2 (TIGR03714; HMM-score: 881.9)
    and 2 more
    accessory Sec system translocase SecA2 (TIGR04221; HMM-score: 574.4)
    SWIM/SEC-C metal-binding motif protein, PBPRA1643 family (TIGR04102; HMM-score: 23.4)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    P-loop_NTPase (CL0023) SecA_DEAD; SecA DEAD-like domain (PF07517; HMM-score: 405.6)
    and 5 more
    no clan defined SecA_SW; SecA Wing and Scaffold domain (PF07516; HMM-score: 195.2)
    SecA_PP_bind; SecA preprotein cross-linking domain (PF01043; HMM-score: 118.9)
    SEC-C; SEC-C motif (PF02810; HMM-score: 37.7)
    P-loop_NTPase (CL0023) DEAD; DEAD/DEAH box helicase (PF00270; HMM-score: 17.3)
    Helicase_C; Helicase conserved C-terminal domain (PF00271; HMM-score: 11.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.89
    • Cytoplasmic Membrane Score: 0.09
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002383
    • TAT(Tat/SPI): 0.000186
    • LIPO(Sec/SPII): 0.000372
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_120164178 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MANILKTIIENDKGEIRRLEKMADKVFKYEDQMAALTDDQLKAKTVEFKERYQNGESLDSLLYEAFAVVREGAKRVLGLFPYKVQVMGGIVLHHGDVPEMRTGEGKTLTATMPVYLNALSGKGVHVVTVNEYLSERDATEMGELYSWLGLSVGINLATKSPMEKKEAYECDITYSTNSEIGFDYLRDNMVVRAENMVQRPLNYALVDEVDSILIDEARTPLIVSGANAVETSQLYHMADHYVKSLNKDDYIIDVQSKTIGLSDSGIDRAESYFKLENLYDIENVALTHFIDNALRANYIMLLDIDYVVSEEQEILIVDQFTGRTMEGRRYSDGLHQAIEAKEGVPIQDETKTSASITYQNLFRMYKKLSGMTGTGKTEEEEFREIYNIRVIPIPTNRPVQRIDHSDLLYASIESKFKAVVEDVKARYQKGQPVLVGTVAVETSDYISKKLVAAGVPHEVLNAKNHYREAQIIMNAGQRGAVTIATNMAGRGTDIKLGEGVRELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDDLMKRFGSERLKGIFERLNMSEEAIESRMLTRQVEAAQKRVEGNNYDTRKQVLQYDDVMREQREIIYAQRYDVITADRDLAPEIQSMIKRTIERVVDGHARAKQDEKLEAILNFAKYNLLPEDSITMEDLSGLSDKAIKEELFQRALKVYDSQVSKLRDEEAVKEFQKVLILRVVDNKWTDHIAALDQLRNAVGLRGYAQNNPVVEYQAEGFRMFNDMIGSIEFDVTRLMMKAQIHEQERPQAERHISTTATRNIAAHQASMPEDLDLSQIGRNELCPCGSGKKFKNCHGKRK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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