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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_RS03990 [old locus tag: MDRSPN_00749 ]
  • pan locus tag?: PNEUPAN002568000
  • symbol: MDRSPN_RS03990
  • pan gene symbol?: ylxM
  • synonym:
  • product: putative DNA-binding protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_RS03990 [old locus tag: MDRSPN_00749 ]
  • symbol: MDRSPN_RS03990
  • product: putative DNA-binding protein
  • replicon: chromosome
  • strand: +
  • coordinates: 759280..759612
  • length: 333
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018391 (759280..759612) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1143 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    ATGGAAATCGAAAAAACCAATCGTATGAATGCGCTCTTTGAATTTTATGCGGCGCTTTTG
    ACAGATAAGCAAATGAATTATATCGAGCTCTACTACGCTGATGATTACAGCCTTGCTGAA
    ATTGCCGAGGAGTTCGGTGTCAGTCGTCAGGCTGTCTATGACAATATCAAGCGAACAGAA
    AAGATTCTGGAAGATTATGAGATGAAATTGCACATGTACTCGGACTATATTGTCCGCAGT
    CAGATTTTTGATCAGATTTTGGAGCGCTATCCCAAGGATAACTTTCTGCAGGAGCAGATA
    GAAATTTTAACAAGCATTGATAATAGAGAATAA
    60
    120
    180
    240
    300
    333

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_RS03990 [old locus tag: MDRSPN_00749 ]
  • symbol: MDRSPN_RS03990
  • description: putative DNA-binding protein
  • length: 110
  • theoretical pI: 4.15394
  • theoretical MW: 13346.9
  • GRAVY: -0.560909

⊟Function[edit | edit source]

  • TIGRFAM:
    RNA polymerase sigma factor, sigma-70 family (TIGR02937; HMM-score: 35.6)
    and 6 more
    RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family (TIGR02989; HMM-score: 20)
    RNA polymerase sigma-70 factor, Bacteroides expansion family 1 (TIGR02985; HMM-score: 19.9)
    RNA polymerase sigma-70 factor, sigma-E family (TIGR02983; HMM-score: 16.8)
    RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1 (TIGR02984; HMM-score: 16.3)
    transcriptional regulator BotR, P-21 (TIGR03209; HMM-score: 15.8)
    probable regulatory domain (TIGR03879; HMM-score: 14.2)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    HTH (CL0123) UPF0122; Putative helix-turn-helix protein, YlxM / p13 like (PF04297; HMM-score: 143.3)
    and 31 more
    Sigma70_r4; Sigma-70, region 4 (PF04545; HMM-score: 31.2)
    Sigma70_r4_2; Sigma-70, region 4 (PF08281; HMM-score: 29.7)
    HTH_23; Homeodomain-like domain (PF13384; HMM-score: 25.4)
    HTH_28; Helix-turn-helix domain (PF13518; HMM-score: 25.3)
    HTH_11; HTH domain (PF08279; HMM-score: 23.6)
    HTH_10; HTH DNA binding domain (PF04967; HMM-score: 23.1)
    Mga; Mga helix-turn-helix domain (PF05043; HMM-score: 20.9)
    HTH_Tnp_1_2; Helix-turn-helix of insertion element transposase (PF13022; HMM-score: 20.8)
    HTH_7; Helix-turn-helix domain of resolvase (PF02796; HMM-score: 20.7)
    Sigma70_ECF; ECF sigma factor (PF07638; HMM-score: 20.4)
    HTH_38; Helix-turn-helix domain (PF13936; HMM-score: 19.7)
    Phage_antitermQ; Phage antitermination protein Q (PF06530; HMM-score: 18.5)
    Terminase_5; Putative ATPase subunit of terminase (gpP-like) (PF06056; HMM-score: 17.9)
    HTH_29; Winged helix-turn helix (PF13551; HMM-score: 17.8)
    HTH_40; Helix-turn-helix domain (PF14493; HMM-score: 15.9)
    HTH_AsnC-type; AsnC-type helix-turn-helix domain (PF13404; HMM-score: 15.2)
    CENP-B_N; CENP-B N-terminal DNA-binding domain (PF04218; HMM-score: 15)
    DUF2089; Protein of unknown function (DUF2089) (PF09862; HMM-score: 15)
    HTH_30; PucR C-terminal helix-turn-helix domain (PF13556; HMM-score: 15)
    HTH_17; Helix-turn-helix domain (PF12728; HMM-score: 14.7)
    DUF433; Protein of unknown function (DUF433) (PF04255; HMM-score: 14.5)
    HTH_Tnp_4; Helix-turn-helix of DDE superfamily endonuclease (PF13613; HMM-score: 14.5)
    TetR_N; Bacterial regulatory proteins, tetR family (PF00440; HMM-score: 14.4)
    HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 14.4)
    MarR_2; MarR family (PF12802; HMM-score: 14.3)
    GcrA; GcrA cell cycle regulator (PF07750; HMM-score: 14)
    TrmB; Sugar-specific transcriptional regulator TrmB (PF01978; HMM-score: 13.8)
    HTH_22; HTH domain (PF13309; HMM-score: 13.5)
    Peptidase_MA (CL0126) Peptidase_M78; IrrE N-terminal-like domain (PF06114; HMM-score: 13.2)
    no clan defined Nup54_57_C; NUP57/Nup54 C-terminal domain (PF18570; HMM-score: 13)
    HTH (CL0123) MarR; MarR family (PF01047; HMM-score: 12.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9669
    • Cytoplasmic Membrane Score: 0.0077
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0253
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003823
    • TAT(Tat/SPI): 0.000218
    • LIPO(Sec/SPII): 0.001226
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000402071 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MEIEKTNRMNALFEFYAALLTDKQMNYIELYYADDYSLAEIAEEFGVSRQAVYDNIKRTEKILEDYEMKLHMYSDYIVRSQIFDQILERYPKDNFLQEQIEILTSIDNRE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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