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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_RS05080 [old locus tag: MDRSPN_00973 ]
  • pan locus tag?: PNEUPAN002272000
  • symbol: serB
  • pan gene symbol?: serB
  • synonym:
  • product: phosphoserine phosphatase SerB

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_RS05080 [old locus tag: MDRSPN_00973 ]
  • symbol: serB
  • product: phosphoserine phosphatase SerB
  • replicon: chromosome
  • strand: +
  • coordinates: 981008..981652
  • length: 645
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018391 (981008..981652) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1009 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGTCTCAAGTAATGGGGCTCTGTGTCATGGACGTTGACGGAACCCTGATAGCAGAGGAA
    GTGATTGATCTTTTAGGAAGAGAAGCAGGTTGCGAAGAAGAAATTTCGCAGATTACAAGA
    CAGGCAATGCGAGGTGAACTGGACTTTGAAACAAGTTTACGAGCGAGGGTAGCTTTGTTA
    AAAGGCCTTCCGGTTTCGGTCTTTGATACTGTCTTCAAATCCATTCATCTGTCCAAGAAT
    GCTCAAGAATTTATCTACATCCTTCAAAAGAAGGGTATTCTAGTCGGTCTAGTGTCTGGT
    GGATTTGCACCAATAGTTGAGAGATTAGCAAAATCCCTTGGTATTTCCTATTTCTCCGCC
    AACCAGTTAGAAGTCAAAGACGGATTTTTAACAGGAAAATTAGTTGGTAAAATTGTGACA
    AGTCAAGTAAAAAATGCTACTCTTGAGAAATGGAGAAAGGAATTAGGACTTTCCAAAGAA
    AGAACGATTGCCATCGGTGATGGTGCTAACGACCTCTTGATGCTAAAGTCAGCAGGACGT
    GGTATTGCATTTTGTGCCAAAGAATTCGTAAAATCTGAGATAGCTTGTCATGTAGATAAA
    AGGGATTTTTTGGAAGCTCTACCTTTGATTGATTTCTTAGAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    645

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_RS05080 [old locus tag: MDRSPN_00973 ]
  • symbol: SerB
  • description: phosphoserine phosphatase SerB
  • length: 214
  • theoretical pI: 5.88849
  • theoretical MW: 23452.3
  • GRAVY: 0.188318

⊟Function[edit | edit source]

  • reaction:
    EC 3.1.3.3?  ExPASy
    Phosphoserine phosphatase O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Serine family phosphoserine phosphatase SerB (TIGR00338; EC 3.1.3.3; HMM-score: 229.6)
    and 23 more
    Unknown function Enzymes of unknown specificity HAD phosphoserine phosphatase-like hydrolase, family IB (TIGR01488; HMM-score: 111.5)
    phosphoserine phosphatase-like hydrolase, archaeal (TIGR01491; HMM-score: 91.5)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IB (TIGR01490; HMM-score: 63.4)
    Unknown function Enzymes of unknown specificity Cof-like hydrolase (TIGR00099; HMM-score: 51.2)
    phosphoglycolate phosphatase, TA0175-type (TIGR01487; EC 3.1.3.18; HMM-score: 45)
    phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein (TIGR02137; EC 3.1.3.3; HMM-score: 34.8)
    HAD ATPase, P-type, family IC (TIGR01494; EC 3.6.3.-; HMM-score: 30.4)
    Metabolism Central intermediary metabolism Other 2,3-diketo-5-methylthio-1-phosphopentane phosphatase (TIGR01489; HMM-score: 30.2)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIB (TIGR01484; HMM-score: 28.7)
    Cellular processes Cellular processes Detoxification copper-translocating P-type ATPase (TIGR01511; EC 3.6.3.4; HMM-score: 28.5)
    Metabolism Transport and binding proteins Cations and iron carrying compounds copper-translocating P-type ATPase (TIGR01511; EC 3.6.3.4; HMM-score: 28.5)
    sucrose-phosphate phosphatase subfamily (TIGR01482; EC 3.1.3.-; HMM-score: 26.4)
    heavy metal translocating P-type ATPase (TIGR01525; EC 3.6.3.-; HMM-score: 22.1)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIIA (TIGR01662; HMM-score: 21.4)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family (TIGR01670; EC 3.1.3.45; HMM-score: 18.7)
    HAD phosphatase, family IIIC (TIGR01681; HMM-score: 16.2)
    mannosyl-3-phosphoglycerate phosphatase family (TIGR01486; EC 3.1.3.-; HMM-score: 15.5)
    Unknown function General mannosyl-3-phosphoglycerate phosphatase homolog (TIGR02463; EC 3.1.3.-; HMM-score: 15.2)
    phospholipid-translocating P-type ATPase, flippase (TIGR01652; EC 3.6.3.1; HMM-score: 14)
    Metabolism Transport and binding proteins Cations and iron carrying compounds cadmium-translocating P-type ATPase (TIGR01512; EC 3.6.3.3; HMM-score: 13.2)
    Metabolism Amino acid biosynthesis Aspartate family 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase (TIGR03333; EC 3.1.3.-; HMM-score: 12.5)
    Metabolism Central intermediary metabolism Sulfur metabolism 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase (TIGR03333; EC 3.1.3.-; HMM-score: 12.5)
    P-type ATPase of unknown pump specificity (type V) (TIGR01657; HMM-score: 12)
  • TheSEED:
  • PFAM:
    HAD (CL0137) HAD; haloacid dehalogenase-like hydrolase (PF12710; HMM-score: 83.1)
    Hydrolase; haloacid dehalogenase-like hydrolase (PF00702; HMM-score: 67.7)
    and 6 more
    Hydrolase_3; haloacid dehalogenase-like hydrolase (PF08282; HMM-score: 47.3)
    HAD_2; haloacid dehalogenase-like hydrolase (PF13419; HMM-score: 28.3)
    no clan defined Peptidase_C74; Pestivirus NS2 peptidase (PF12387; HMM-score: 17.3)
    HAD (CL0137) S6PP; Sucrose-6F-phosphate phosphohydrolase (PF05116; HMM-score: 14.6)
    Put_Phosphatase; Putative Phosphatase (PF06888; HMM-score: 14.5)
    no clan defined PMT2_N; Phosphoethanolamine N-methyltransferase 2 N-terminal (PF17987; HMM-score: 14.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005148
    • TAT(Tat/SPI): 0.000189
    • LIPO(Sec/SPII): 0.000739
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_120164213 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSQVMGLCVMDVDGTLIAEEVIDLLGREAGCEEEISQITRQAMRGELDFETSLRARVALLKGLPVSVFDTVFKSIHLSKNAQEFIYILQKKGILVGLVSGGFAPIVERLAKSLGISYFSANQLEVKDGFLTGKLVGKIVTSQVKNATLEKWRKELGLSKERTIAIGDGANDLLMLKSAGRGIAFCAKEFVKSEIACHVDKRDFLEALPLIDFLE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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