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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_RS10565 [old locus tag: MDRSPN_02006 ]
  • pan locus tag?: PNEUPAN003923000
  • symbol: MDRSPN_RS10565
  • pan gene symbol?: clpC
  • synonym:
  • product: ATP-dependent Clp protease ATP-binding subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_RS10565 [old locus tag: MDRSPN_02006 ]
  • symbol: MDRSPN_RS10565
  • product: ATP-dependent Clp protease ATP-binding subunit
  • replicon: chromosome
  • strand: -
  • coordinates: 1998446..2000878
  • length: 2433
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018391 (1998446..2000878) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_2022 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    ATGAACTATTCAAAAGCATTGAATGAATGTATCGAAAGTGCCTACATGGTTGCTGGATAT
    TTTGGAGCTCGTTATCTAGAGTCTTGGCACTTGTTGATTGCCATGTCTAATCACAGTTAT
    AGTGTAGCAGGGGCAACTTTAAATGATTATCCGTATGAGATGGACCGTTTAGAAGAGGTG
    GCTTTGGAACTGACTGAAACGGACTATAGCCAGGATGAAACCTTTACGGAATTGCCGTTC
    TCCCGTCGTTTGCAGGTTCTTTTTGATGAAGCAGAGTATGTAGCGTCAGTGGTCCATGCT
    AAGGTACTAGGGACAGAGCACGTCCTCTATGCGATTTTGCATGATGGCAATGCCTTGGCG
    ACTCGTATCTTGGAGAGGGCTGGTTTTTCTTATGAAGACAAGAAAGATCAGGTCAAGATT
    GCTGCTCTTCGTCGAAATTTAGAAGAACGGGCAGGCTGGACTCGTGAAGATCTCAAGGCT
    TTACGCCAACGCCATCGTACAGTAGCTGACAAGCAAAATTCTATGGCCAATATGATGGGC
    ATGCCGCAGACTCCTAGTGGTGGTCTCGAGGACTATACGCATGATTTGACAGAGCAAGCG
    CGTTCTGGCAAGTTAGAACCAGTCATCGGTCGGGACAAGGAAATCTCACGTATGATTCAA
    ATCTTGAGCCGTAAGACTAAGAACAACCCTGTCTTGGTTGGGGATGCTGGTGTCGGGAAA
    ACAGCTCTGGCGCTTGGTCTTGCTCAGCGTATTGCTAGTGGTGACGTGCCTGCGGAAATG
    GCTAAGATGCGCGTGTTAGAACTTGATTTGATGAATGTCGTTGCAGGGACACGCTTCCGT
    GGTGACTTTGAAGAACGCATGAATAATATCATCAAGGATATTGAAGAAGATGGCCAAGTC
    ATCCTCTTTATCGATGAACTTCACACCATCATGGGTTCTGGTAGCGGGATTGATTCGACT
    CTGGATGCGGCCAATATCTTGAAACCAGCCTTGGCGCGTGGAACTTTGAGAACGGTTGGT
    GCCACCACTCAGGAAGAATATCAAAAACATATCGAAAAAGATGCAGCACTTTCTCGTCGT
    TTCGCTAAAGTGACGATTGAAGAACCAAGTGTGGCAGATAGTATGACTATTTTACAAGGT
    TTGAAGGCGACTTATGAGAAACATCACCGTGTACAAATCACAGATGAAGCGGTTGAAACA
    GCGGTTAAGATGGCTCATCGTTATTTAACCAGTCGTCACTTGCCAGACTCTGCTATCGAT
    CTCTTGGATGAGGCGGCAGCAACAGTGCAAAATAAATCAAAGCATGTAAAAGCAGACGAT
    TCTGACTTGAGTCCAGCTGACAAGGCCTTGATGGATGGCAAGTGGAAACAGGCAGCCCAG
    CTAATCGCAAAAGAAGAGGAAGTGCCTGTCTATAAAGACTTGGTGACAGAATCTGATATT
    TTGACCACCTTGAGTCGCTTGTCAGGTATCCCCGTTCAAAAACTGACTCAGACTGATGCC
    AAGAAATACTTAAACTTGGAAGCTGAACTGCACAAACGTGTCATCGGTCAAGACCAAGCT
    GTTTCAAGTATTAGTCGTGCCATTCGCCGCAATCAGTCAGGAATTCGCAGTCACAAGCGT
    CCGATCGGTTCCTTTATGTTCCTAGGACCCACAGGTGTCGGTAAGACCGAGTTGGCCAAG
    GCTTTGGCAGAAGTTCTCTTTGATGACGAATCAGCCCTTATCCGCTTTGATATGAGTGAG
    TATATGGAGAAATTCGCAGCCAGCCGTCTAAATGGAGCTCCTCCAGGCTATGTGGGTTAC
    GAAGAAGGTGGGGAGTTGACAGAGAAGGTTCGCAATAAACCCTATTCCGTTCTCCTCTTT
    GATGAGGTAGAGAAGGCCCATCCAGATATCTTTAATGTTCTCTTGCAGGTTCTGGATGAC
    GGTGTCTTGACAGATAGCAAGGGACGCAAGGTCGATTTTTCAAATACCATTATCATTATG
    ACATCGAACTTAGGTGCGACTGCCCTTCGTGATGATAAGACTGTTGGTTTTGGGGCTAAG
    GATATTCGTTTTGACCAGGAAAATATGGAAAAACGCATGTTTGAAGAACTGAAAAAAGCT
    TATAGACCGGAATTCATCAACCGTATTGATGAGAAGGTGGTCTTCCATAGCCTATCTAGT
    GACCATATGCAGGAAGTGGTGAAGATTATGGTCAAGCCTTTAGTGGCAAGTTTGGCTGAA
    AAAGGCATTGACTTGAAATTACAAGCTTCAGCTCTGAAATTGTTAGCAAATCAAGGATAT
    GACCCAGAGATGGGAGCTCGCCCACTTCGCAGAACCCTGCAAACAGAAGTGGAGGACAAG
    TTGGCAGAACTTCTTCTTAAGGGAGATTTAGTGGCAGGCAGCACACTTAAGATTGGTGTC
    AAAGCAGGCCAGTTAAAATTTGATATTGCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2433

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_RS10565 [old locus tag: MDRSPN_02006 ]
  • symbol: MDRSPN_RS10565
  • description: ATP-dependent Clp protease ATP-binding subunit
  • length: 810
  • theoretical pI: 5.78683
  • theoretical MW: 90195.3
  • GRAVY: -0.336543

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein fate Protein folding and stabilization ATP-dependent chaperone protein ClpB (TIGR03346; HMM-score: 866.5)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent Clp protease ATP-binding subunit ClpA (TIGR02639; HMM-score: 759.1)
    and 25 more
    Cellular processes Cellular processes Pathogenesis type VI secretion ATPase, ClpV1 family (TIGR03345; HMM-score: 676.5)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VI secretion ATPase, ClpV1 family (TIGR03345; HMM-score: 676.5)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent Clp protease, ATP-binding subunit ClpX (TIGR00382; HMM-score: 43.3)
    Genetic information processing Protein fate Protein folding and stabilization ATP-dependent Clp protease, ATP-binding subunit ClpX (TIGR00382; HMM-score: 43.3)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VII secretion AAA-ATPase EccA (TIGR03922; HMM-score: 33.1)
    Genetic information processing Protein fate Protein folding and stabilization ATP-dependent protease HslVU, ATPase subunit (TIGR00390; HMM-score: 32.2)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, subunit gamma and tau (TIGR02397; EC 2.7.7.7; HMM-score: 30.8)
    Cellular processes Cellular processes Other gas vesicle protein GvpN (TIGR02640; HMM-score: 30.1)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides putative ATP-dependent protease (TIGR00764; HMM-score: 25.9)
    AAA family ATPase, CDC48 subfamily (TIGR01243; HMM-score: 23.5)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair orc1/cdc6 family replication initiation protein (TIGR02928; HMM-score: 23)
    Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 22.8)
    arsenical pump-driving ATPase (TIGR04291; EC 3.6.1.-; HMM-score: 21.4)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DnaA regulatory inactivator Hda (TIGR03420; HMM-score: 21)
    26S proteasome subunit P45 family (TIGR01242; HMM-score: 20.3)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair Holliday junction DNA helicase RuvB (TIGR00635; EC 3.6.4.12; HMM-score: 20)
    Cellular processes Cellular processes Sporulation and germination ATP-dependent protease LonB (TIGR02902; EC 3.4.21.-; HMM-score: 20)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent protease LonB (TIGR02902; EC 3.4.21.-; HMM-score: 20)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, delta' subunit (TIGR00678; EC 2.7.7.7; HMM-score: 19.9)
    Cellular processes Cellular processes Sporulation and germination stage V sporulation protein K (TIGR02881; HMM-score: 16.4)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA dimethylallyltransferase (TIGR00174; EC 2.5.1.75; HMM-score: 16.3)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides endopeptidase La (TIGR00763; EC 3.4.21.53; HMM-score: 13.8)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA threonylcarbamoyl adenosine modification protein YjeE (TIGR00150; HMM-score: 12.8)
    Unknown function General Mg chelatase-like protein (TIGR00368; HMM-score: 12.7)
    Metabolism Central intermediary metabolism Sulfur metabolism adenylyl-sulfate kinase (TIGR00455; EC 2.7.1.25; HMM-score: 12.5)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    P-loop_NTPase (CL0023) AAA_2; AAA domain (Cdc48 subfamily) (PF07724; HMM-score: 191.2)
    and 41 more
    AAA_lid (CL0671) AAA_lid_9; AAA lid domain (PF17871; HMM-score: 93.6)
    P-loop_NTPase (CL0023) AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 83.4)
    AAA_lid (CL0671) ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein (PF10431; HMM-score: 81.2)
    P-loop_NTPase (CL0023) AAA_5; AAA domain (dynein-related subfamily) (PF07728; HMM-score: 56.5)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 45.4)
    Sigma54_activat; Sigma-54 interaction domain (PF00158; HMM-score: 41.8)
    AAA_14; AAA domain (PF13173; HMM-score: 32.5)
    no clan defined Clp_N; Clp amino terminal domain, pathogenicity island component (PF02861; HMM-score: 31.5)
    P-loop_NTPase (CL0023) ATPase_2; ATPase domain predominantly from Archaea (PF01637; HMM-score: 31.4)
    AAA_22; AAA domain (PF13401; HMM-score: 29.9)
    IstB_IS21; IstB-like ATP binding protein (PF01695; HMM-score: 28)
    NACHT; NACHT domain (PF05729; HMM-score: 26.4)
    AAA_18; AAA domain (PF13238; HMM-score: 24.3)
    Mg_chelatase; Magnesium chelatase, subunit ChlI (PF01078; HMM-score: 22.9)
    TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 22.8)
    TniB; Bacterial TniB protein (PF05621; HMM-score: 22.8)
    AAA_7; P-loop containing dynein motor region (PF12775; HMM-score: 21.8)
    AAA_25; AAA domain (PF13481; HMM-score: 21.5)
    Roc; Ras of Complex, Roc, domain of DAPkinase (PF08477; HMM-score: 21.2)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 20.9)
    RNA_helicase; RNA helicase (PF00910; HMM-score: 20.1)
    RuvB_N; Holliday junction DNA helicase RuvB P-loop domain (PF05496; HMM-score: 19.9)
    AAA_24; AAA domain (PF13479; HMM-score: 19.7)
    DNA_pol3_delta2; DNA polymerase III, delta subunit (PF13177; HMM-score: 18.4)
    Torsin; Torsin (PF06309; HMM-score: 18.3)
    ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 18.1)
    ABC_tran; ABC transporter (PF00005; HMM-score: 18)
    AAA_33; AAA domain (PF13671; HMM-score: 16.7)
    CbiA; CobQ/CobB/MinD/ParA nucleotide binding domain (PF01656; HMM-score: 16.2)
    TIP49; TIP49 P-loop domain (PF06068; HMM-score: 16.1)
    PhoH; PhoH-like protein (PF02562; HMM-score: 15.7)
    AAA_28; AAA domain (PF13521; HMM-score: 15.2)
    PduV-EutP; Ethanolamine utilisation - propanediol utilisation (PF10662; HMM-score: 15)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 13.9)
    SRP54; SRP54-type protein, GTPase domain (PF00448; HMM-score: 13)
    no clan defined FTA4; Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 (PF13093; HMM-score: 12.9)
    P-loop_NTPase (CL0023) NTPase_1; NTPase (PF03266; HMM-score: 12.8)
    Acetyltrans (CL0257) Acetyltransf_4; Acetyltransferase (GNAT) domain (PF13420; HMM-score: 12.7)
    P-loop_NTPase (CL0023) DUF87; Helicase HerA, central domain (PF01935; HMM-score: 12.6)
    AAA_3; ATPase family associated with various cellular activities (AAA) (PF07726; HMM-score: 12)
    Met_repress (CL0057) PSK_trans_fac; Rv0623-like transcription factor (PF07704; HMM-score: 11.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.057574
    • TAT(Tat/SPI): 0.008044
    • LIPO(Sec/SPII): 0.002197
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_120164315 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNYSKALNECIESAYMVAGYFGARYLESWHLLIAMSNHSYSVAGATLNDYPYEMDRLEEVALELTETDYSQDETFTELPFSRRLQVLFDEAEYVASVVHAKVLGTEHVLYAILHDGNALATRILERAGFSYEDKKDQVKIAALRRNLEERAGWTREDLKALRQRHRTVADKQNSMANMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRMIQILSRKTKNNPVLVGDAGVGKTALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAGTRFRGDFEERMNNIIKDIEEDGQVILFIDELHTIMGSGSGIDSTLDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSVADSMTILQGLKATYEKHHRVQITDEAVETAVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKSKHVKADDSDLSPADKALMDGKWKQAAQLIAKEEEVPVYKDLVTESDILTTLSRLSGIPVQKLTQTDAKKYLNLEAELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAKALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDDGVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDIRFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSSDHMQEVVKIMVKPLVASLAEKGIDLKLQASALKLLANQGYDPEMGARPLRRTLQTEVEDKLAELLLKGDLVAGSTLKIGVKAGQLKFDIA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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