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serotype 4
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EF3030
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serotype 6B
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serotype 23F
BM6001
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CGSP14
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G54
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HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
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MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
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OXC141
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SP49
serotype 19A
SPN032672
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SPN034156
serotype 3
SPN034183
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SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
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ST556
serotype 19F
TCH8431/19A
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Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 03-AUG-2015

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ST556
  • locus tag: MYY_1192 [new locus tag: MYY_RS06105 ]
  • pan locus tag?: PNEUPAN002389000
  • symbol: MYY_1192
  • pan gene symbol?: acoA
  • synonym:
  • product: pyruvate dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MYY_1192 [new locus tag: MYY_RS06105 ]
  • symbol: MYY_1192
  • product: pyruvate dehydrogenase
  • replicon: chromosome
  • strand: -
  • coordinates: 1175761..1176729
  • length: 969
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGTCAACTTTAGATAAAAATCTTTTGCTAGAAATGTTCCGTAAGATGGAAGAAATCCGT
    CGCATGGACTTAAAAATTGCACAATTAGTAAAGAAAGGGAAAGTGCCAGGAATGACGCAC
    TTTTCTGTTGGTGAAGAGGCAGCTAACGTGGGGGCTATGTTAGCTCTCAATCCAGATGAT
    CTGATTACCTCAAACCACCGTGGACACGGGCAAGCTATTGCTAAAGGGATTGACCTCAAC
    GGAATGATGGCTGAAATCCTTGGTAAATACACTGGAACCTGTAAAGGGAAAGGTGGATCT
    ATGCATATCGCTGACCTTGATGCTGGGAACCTTGGTGCCAATGGTATCGTAGGTGGTGGT
    ATGGGGATCGCTGTCGGTGCAGCCCTCAGTCAGCAAATGCAAAATACCGGTAAAATCGTT
    GTCTGCTTCTTTGGAGATGGTGCGACCAATGAAGGTGTTTTCCACGAAGCAGTGAACATG
    GCTTCTATCTGGAACCTGCCAGTCATTTTCTATTGCATTAACAACGGTTACGGTATCTCT
    GCGGATATCAAGAAAATGACCAATATAGAACATATCCATCAACGTAGCGCCGCTTATGGA
    ATTCCTGGAATGTTCATCGAAGACGGTAACAATGTCATCGATGTCTATGAAGGATTTCAG
    AAAGCTGTAGACCATGTTCGCAGTGGCAATGGTCCAGTCTTGATTGAAAGTGTAACTTAT
    CGCTGGCTCGGTCACTCATCATCTGACCCTGGTAAATATCGTACGCGTGAAGAAGTGGAA
    TTGTGGAAACAAAAAGATCCAATCGAAAACCTCCGCAATTACCTTATTGAAAATAACATT
    GCAAGTGCCGAAGAATTGGAAGAAATCCAAGCGCAAGTAAAGGAAGCAGTAGAAGCTTCT
    GTTAAATTTGCAGAGGAAAGCCCATTCCCACCGCTTGAATCAGCCTTTGAAGATATTTAC
    GCAGACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    969

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MYY_1192 [new locus tag: MYY_RS06105 ]
  • symbol: MYY_1192
  • description: pyruvate dehydrogenase
  • length: 322
  • theoretical pI: 4.89766
  • theoretical MW: 35080.7
  • GRAVY: -0.204969

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Energy metabolism Pyruvate dehydrogenase pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit (TIGR03182; EC 1.2.4.1; HMM-score: 364)
    and 8 more
    Metabolism Energy metabolism Pyruvate dehydrogenase pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit (TIGR03181; EC 1.2.4.1; HMM-score: 272.7)
    Metabolism Energy metabolism Pentose phosphate pathway transketolase (TIGR00232; EC 2.2.1.1; HMM-score: 31.7)
    Metabolism Energy metabolism TCA cycle oxoglutarate dehydrogenase (succinyl-transferring), E1 component (TIGR00239; EC 1.2.4.2; HMM-score: 29.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 23.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 23.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridoxine 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 23.5)
    Cellular processes Cellular processes Detoxification oxalyl-CoA decarboxylase (TIGR03254; EC 4.1.1.8; HMM-score: 21.5)
    Metabolism Amino acid biosynthesis Pyruvate family acetolactate synthase, large subunit, biosynthetic type (TIGR00118; EC 2.2.1.6; HMM-score: 13.2)
  • TheSEED  :
    • Acetoin dehydrogenase E1 component alpha-subunit (EC 1.2.4.-)
    Carbohydrates Central carbohydrate metabolism Dehydrogenase complexes  Acetoin dehydrogenase E1 component alpha-subunit (EC 1.2.4.-)
    and 1 more
    Carbohydrates Fermentation Acetoin, butanediol metabolism  Acetoin dehydrogenase E1 component alpha-subunit (EC 1.2.4.-)
  • PFAM:
    THDP-binding (CL0254) E1_dh; Dehydrogenase E1 component (PF00676; HMM-score: 282.2)
    and 3 more
    TPP_enzyme_C; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain (PF02775; HMM-score: 34.8)
    Transketolase_N; Transketolase, thiamine diphosphate binding domain (PF00456; HMM-score: 25.6)
    DXP_synthase_N; 1-deoxy-D-xylulose-5-phosphate synthase (PF13292; HMM-score: 21.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9694
    • Cytoplasmic Membrane Score: 0.002
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0284
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004603
    • TAT(Tat/SPI): 0.003939
    • LIPO(Sec/SPII): 0.000636
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: AFC94849 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSTLDKNLLLEMFRKMEEIRRMDLKIAQLVKKGKVPGMTHFSVGEEAANVGAMLALNPDDLITSNHRGHGQAIAKGIDLNGMMAEILGKYTGTCKGKGGSMHIADLDAGNLGANGIVGGGMGIAVGAALSQQMQNTGKIVVCFFGDGATNEGVFHEAVNMASIWNLPVIFYCINNGYGISADIKKMTNIEHIHQRSAAYGIPGMFIEDGNNVIDVYEGFQKAVDHVRSGNGPVLIESVTYRWLGHSSSDPGKYRTREEVELWKQKDPIENLRNYLIENNIASAEELEEIQAQVKEAVEASVKFAEESPFPPLESAFEDIYAD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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