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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 03-AUG-2015
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae ST556
- locus tag: MYY_1766 [new locus tag: MYY_RS09115 ]
- pan locus tag?: PNEUPAN003394000
- symbol: MYY_1766
- pan gene symbol?: piuA
- synonym:
- product: iron ABC transporter substrate-binding protein
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: MYY_1766 [new locus tag: MYY_RS09115 ]
- symbol: MYY_1766
- product: iron ABC transporter substrate-binding protein
- replicon: chromosome
- strand: +
- coordinates: 1738785..1739750
- length: 966
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: CP003357 (1738785..1739750) NCBI
- BioCyc: see MYY_RS09115
- MicrobesOnline:
- PneumoBrowse for strain D39V: SPV_1652 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
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961ATGAAAACATCCCTTAAACTTTATTTCACTGCCCTAGTGGCCAGCTTCTTGCTCCTACTT
GGTGCATGTAGTACAAACTCAAGCACTAGTCAGACAGAGACCAGTAGCTCTGCTCCAACA
GAGGTAACCATTAAAAGTTCACTGGACGAGGTCAAACTTTCCAAAGTTCCTGAAAAGATT
GTGACCTTTGACCTCGGCGCTGCGGATACTATTCGCGCTTTAGGATTTGCAAAAAATATC
GTCGGAATGCCTACAAAAACTGTTCCGACTTATCTAAAAGACCTAGTGGGAACTGTCAAA
AATGTTGGTTCTATGAAAGAACCTGATTTAGAAGCTATCGCCGCCCTTGAGCCTGATTTG
ATTATCGCTTCACCACGTACACAAAAATTCGTAGACAAATTCAAAGAAATCGCCCCAACC
GTTCTCTTCCAAGCAAGCAAGGACGACTACTGGACTTCTACCAAGGCTAATATCGAATCC
TTAGCAAGTGCCTTCGGCGAAACTGGTACACAGAAAGCCAAGGAAGAATTGGCCAAGCTA
GACAAGAGCATCCAAGAAGTCGCTACTAAAAATGAAAGCTCTGACAAAAAAGCCCTTGCG
ATCCTCCTTAATGAAGGAAAAATGGCAGCCTTTGGTGCCAAATCTCGTTTCTCTTTCTTG
TACCAAACCTTGAAATTCAAACCAACTGATACAAAATTTGAAGACTCACGCCACGGACAA
GAAGTCAGCTTTGAAAGTGTCAAAGAAATCAACCCTGACATCCTCTTTGTCATCAACCGT
ACCCTTGCCATCGGTGGGGACAACTCTAGCAACGACGGTGTCCTAGAAAATGCCCTTATC
GCTGAAACACCTGCTGCTAAAAATGGTAAGATTATCCAACTAACACCAGACCTCTGGTAT
CTAAGCGGAGGCGGACTTGAATCAACAAAACTCATGATTGAAGACATACAAAAAGCTTTG
AAATAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: MYY_1766 [new locus tag: MYY_RS09115 ]
- symbol: MYY_1766
- description: iron ABC transporter substrate-binding protein
- length: 321
- theoretical pI: 5.58221
- theoretical MW: 34760.6
- GRAVY: -0.153894
⊟Function[edit | edit source]
- TIGRFAM: heme ABC transporter, heme-binding protein isdE (TIGR03659; HMM-score: 54.9)putative ABC transporter PGF-CTERM-modified substrate-binding protein (TIGR04281; HMM-score: 48.4)and 1 moreproposed F420-0 ABC transporter, periplasmic F420-0 binding protein (TIGR03868; HMM-score: 24.8)
- TheSEED :
- Iron compound ABC uptake transporter substrate-binding protein PiuA
- PFAM: Chelatase (CL0043) Peripla_BP_2; Periplasmic binding protein (PF01497; HMM-score: 120.1)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic Membrane
- Cytoplasmic Score: 0.17
- Cytoplasmic Membrane Score: 9.51
- Cellwall Score: 0.16
- Extracellular Score: 0.15
- Internal Helix: 1
- DeepLocPro: Cytoplasmic Membrane
- Cytoplasmic Score: 0
- Cytoplasmic Membrane Score: 0.9859
- Cell wall & surface Score: 0.0004
- Extracellular Score: 0.0136
- SignalP: Signal peptide LIPO(Sec/SPII) length 22 aa
- SP(Sec/SPI): 0.000583
- TAT(Tat/SPI): 0.00007
- LIPO(Sec/SPII): 0.999223
- Cleavage Site: CS pos: 22-23. LGA-CS. Pr: 0.9994
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq: AFC95421 NCBI
- UniProt:
⊟Protein sequence[edit | edit source]
- MKTSLKLYFTALVASFLLLLGACSTNSSTSQTETSSSAPTEVTIKSSLDEVKLSKVPEKIVTFDLGAADTIRALGFAKNIVGMPTKTVPTYLKDLVGTVKNVGSMKEPDLEAIAALEPDLIIASPRTQKFVDKFKEIAPTVLFQASKDDYWTSTKANIESLASAFGETGTQKAKEELAKLDKSIQEVATKNESSDKKALAILLNEGKMAAFGAKSRFSFLYQTLKFKPTDTKFEDSRHGQEVSFESVKEINPDILFVINRTLAIGGDNSSNDGVLENALIAETPAAKNGKIIQLTPDLWYLSGGGLESTKLMIEDIQKALK
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_1652 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
Maha Jomaa, Jose Yuste, James C Paton, Christopher Jones, Gordon Dougan, Jeremy S Brown
Antibodies to the iron uptake ABC transporter lipoproteins PiaA and PiuA promote opsonophagocytosis of Streptococcus pneumoniae.
Infect Immun: 2005, 73(10);6852-9
[PubMed:16177364] [WorldCat.org] [DOI] (P p)