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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ST556
  • locus tag: MYY_RS05535 [old locus tag: MYY_1083 ]
  • pan locus tag?: PNEUPAN002047000
  • symbol: glyA
  • pan gene symbol?: glyA
  • synonym:
  • product: serine hydroxymethyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MYY_RS05535 [old locus tag: MYY_1083 ]
  • symbol: glyA
  • product: serine hydroxymethyltransferase
  • replicon: chromosome
  • strand: +
  • coordinates: 1056011..1057267
  • length: 1257
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017769 (1056011..1057267) NCBI
  • BioCyc: MYY_RS05535 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0910 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGATTTTTGACAAAGATGATTTTAAAGCATATGATGCTGATCTCTGGAATGCTATTGCC
    AAAGAAGAAGAACGCCAACAAAATAATATCGAGTTAATTGCTTCGGAAAACGTAGTTTCC
    AAGGCTGTTATGGCAGCTCAAGGGTCTATCTTGACAAATAAATATGCCGAGGGTTACCCA
    GGACGCCGTTATTATGGTGGAACTGATGTAGTAGACGTTGTAGAGACTCTTGCTATTGAA
    CGCGCAAAAGAAATTTTCGGTGCTAAATTTGCCAATGTCCAACCACATTCAGGAAGCCAA
    GCTAACTGTGCGGCTTACATGTCCTTGATTGAGCCAGGTGATACGGTTATGGGAATGGAT
    TTGGCATCAGGTGGTCATTTGACTCATGGGGCTCCTGTTAGCTTCTCTGGTCAAACCTAC
    AACTTTGTTTCTTATAGTGTTGATCCTGAAACGGAACTCTTAGACTTTGATGCTATCTTG
    AAACAAGCCCAAGAAGTAAAACCAAAACTGATTGTAGCTGGTGCTTCAGCATATTCTCAA
    ATTATCGATTTTTCAAAATTCCGTGAAATCGCAGATGCTGTCGGTGCGAAGCTCATGGTG
    GACATGGCCCATATCGCTGGTTTGGTTGCGGCTGGCCTTCATCCAAGCCCAGTTCCATAC
    GCTCATATCACAACAACAACGACCCACAAAACCCTTCGTGGACCTCGTGGTGGTTTGATT
    TTGACCAATGACGAAGAACTTGCTAAAAAAATCAATTCAGCTATTTTCCCAGGTATTCAG
    GGCGGTCCTTTAGAGCATGTTGTGGCGGCTAAGGCAGTTTCCTTCAAAGAAGTTTTGGAT
    CCAGCCTTCAAGGAATATGCTGCCAATGTAATTAAGAACAGCAAGGCTATGGCAGATGTC
    TTCTTGCAAGACCCTGATTTCCGTATTATTTCAGGTGGAACTGAAAACCATCTCTTCCTT
    GTTGATGTGACTAAGGTTGTAGAAAACGGAAAAGTTGCTCAAAACTTGCTGGATGAAGTC
    AATATTACCCTAAATAAAAATTCAATCCCTTACGAAACCTTGTCGCCATTCAAGACAAGT
    GGGATTCGTATCGGAGCAGCAGCTATTACTGCACGTGGATTTGGTGAAGAAGAAAGTCGC
    AAAGTGGCTGAACTCATCATTAAAACCCTTAAGAATTCAGAAAATGAGGCTGTATTAGAA
    GAAGTGAGAAGTGCAGTCAAAGAATTGACAGATGCCTTCCCATTATACGAGGACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1257

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MYY_RS05535 [old locus tag: MYY_1083 ]
  • symbol: GlyA
  • description: serine hydroxymethyltransferase
  • length: 418
  • theoretical pI: 4.80334
  • theoretical MW: 45258
  • GRAVY: -0.102632

⊟Function[edit | edit source]

  • reaction:
    EC 2.1.2.1?  ExPASy
    Glycine hydroxymethyltransferase 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
  • TIGRFAM:
    Cellular processes Cellular processes Biosynthesis of natural products fluorothreonine transaldolase (TIGR04506; EC 2.2.1.8; HMM-score: 130.1)
    and 10 more
    UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase (TIGR03588; EC 2.6.1.92; HMM-score: 30.8)
    dTDP-4-dehydro-6-deoxyglucose aminotransferase (TIGR04427; EC 2.-.-.-; HMM-score: 30)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin 8-amino-7-oxononanoate synthase (TIGR00858; EC 2.3.1.47; HMM-score: 23.4)
    Metabolism Amino acid biosynthesis Aspartate family O-succinylhomoserine sulfhydrylase (TIGR01325; EC 4.2.99.-; HMM-score: 20.2)
    Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01977; HMM-score: 17.6)
    Metabolism Energy metabolism Amino acids and amines glycine C-acetyltransferase (TIGR01822; EC 2.3.1.29; HMM-score: 17.2)
    Unknown function Enzymes of unknown specificity pyridoxal phosphate enzyme, MJ0158 family (TIGR03576; HMM-score: 15.9)
    putative pyridoxal phosphate-dependent acyltransferase (TIGR01825; EC 2.3.1.-; HMM-score: 15.4)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin 5-aminolevulinic acid synthase (TIGR01821; EC 2.3.1.37; HMM-score: 11.8)
    Metabolism Transport and binding proteins Amino acids, peptides and amines mitochondrial precursor proteins import receptor (TIGR00990; HMM-score: 11.6)
  • TheSEED: see MYY_1083
  • PFAM:
    PLP_aminotran (CL0061) SHMT; Serine hydroxymethyltransferase (PF00464; HMM-score: 552.4)
    and 5 more
    Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 45.2)
    DegT_DnrJ_EryC1; DegT/DnrJ/EryC1/StrS aminotransferase family (PF01041; HMM-score: 33)
    Beta_elim_lyase; Beta-eliminating lyase (PF01212; HMM-score: 25.6)
    no clan defined DUF6115; Family of unknown function (DUF6115) (PF19610; HMM-score: 15.2)
    PLP_aminotran (CL0061) Cys_Met_Meta_PP; Cys/Met metabolism PLP-dependent enzyme (PF01053; HMM-score: 13.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9048
    • Cytoplasmic Membrane Score: 0.0011
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.094
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.016007
    • TAT(Tat/SPI): 0.006044
    • LIPO(Sec/SPII): 0.003753
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000575521 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MIFDKDDFKAYDADLWNAIAKEEERQQNNIELIASENVVSKAVMAAQGSILTNKYAEGYPGRRYYGGTDVVDVVETLAIERAKEIFGAKFANVQPHSGSQANCAAYMSLIEPGDTVMGMDLASGGHLTHGAPVSFSGQTYNFVSYSVDPETELLDFDAILKQAQEVKPKLIVAGASAYSQIIDFSKFREIADAVGAKLMVDMAHIAGLVAAGLHPSPVPYAHITTTTTHKTLRGPRGGLILTNDEELAKKINSAIFPGIQGGPLEHVVAAKAVSFKEVLDPAFKEYAANVIKNSKAMADVFLQDPDFRIISGGTENHLFLVDVTKVVENGKVAQNLLDEVNITLNKNSIPYETLSPFKTSGIRIGAAAITARGFGEEESRKVAELIIKTLKNSENEAVLEEVRSAVKELTDAFPLYED

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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