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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ST556
  • locus tag: MYY_RS06460 [old locus tag: MYY_1262 ]
  • pan locus tag?: PNEUPAN001931000
  • symbol: trmFO
  • pan gene symbol?: trmFO
  • synonym:
  • product: methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MYY_RS06460 [old locus tag: MYY_1262 ]
  • symbol: trmFO
  • product: methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO
  • replicon: chromosome
  • strand: -
  • coordinates: 1236887..1238221
  • length: 1335
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017769 (1236887..1238221) NCBI
  • BioCyc: MYY_RS06460 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0833 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    GTGTCTCAATCTTATATCAATGTTATCGGTGCTGGTTTGGCAGGTTCTGAAGCAGCTTAC
    CAAATCGCAGAGCGTGGTATTCCAGTTAAACTTTATGAAATGCGTGGTGTCAAGTCGACT
    CCTCAGCATAAAACAGACAATTTTGCTGAGTTGGTTTGTTCCAATTCTTTGCGTGGGGAT
    GCTTTGACAAATGCAGTTGGTCTTCTCAAGGAAGAAATGCGTCGCTTGGGTTCTGTTATC
    TTGGAATCTGCTGAGGCTACACGTGTTCCTGCCGGTGGAGCCCTTGCGGTGGATCGTGAT
    GGTTTCTCCCAAATGGTAACCGAAAAAGTGGTCAACCACCCCTTGATTGAAGTGGTGCGT
    GATGAAATTACAGAATTGCCAACAGATGTTATTACAGTTGTGGCGACCGGTCCCTTGACT
    AGCGATGCCCTGGCTGAAAAGATTCATGCCCTTAATGATGGCGATGGCTTCTATTTCTAC
    GATGCAGCAGCGCCTATTATCGATGTCAACACTATCGATATGAGTAAGGTCTATCTCAAA
    TCTCGTTATGATAAGGGAGAAGCAGCCTATCTCAATGCTCCAATGACCAAGCAAGAGTTT
    ATGGATTTCCATGAAGCCTTGGTCAATGCGGAAGAAGCACCGCTCAATTCTTTTGAAAAA
    GAAAAGTACTTTGAAGGATGTATGCCAATCGAAGTTATGGCCAAACGTGGCATTAAAACT
    ATGCTTTATGGCCCTATGAAGCCAGTCGGTCTTGAGTATCCGGACGACTACACAGGACCT
    CGTGATGGAGAATTTAAAACACCTTATGCGGTTGTGCAACTTCGTCAGGATAATGCAGCT
    GGTAGCCTCTACAATATCGTTGGTTTCCAGACCCACCTCAAATGGGGAGAACAAAAGCGT
    GTCTTCCAAATGATTCCGAGTCTTGAAAATGCGGAGTTTGTCCGTTATGGTGTCATGCAT
    CGCAATTCTTACATGGATTCACCAAATCTTCTTGAGCAGACTTACCGTTCTAAGAAACAA
    CCAAATCTCTTCTTTGCTGGTCAGATGACGGGGGTGGAAGGCTATGTTGAGTCGGCGGCT
    TCAGGCTTAGTTGCGGGAATTAACGCAGCTCGTCTCTTCAAGGAAGAAAGCGAGGCTATT
    TTCCCCGATACGACAGCGATTGGAAGCTTAGCTCATTACATTACCCATGCCGACAGCAAA
    CATTTCCAACCAATGAATGTCAATTTTGGGATCATCAAGGAGTTGGAAGGCGAGCGTATC
    CGTGATAAGAAGGCTCGTTATGAAAAAATTGCAGAGCGTGCCCTTGCCGACTTAGAGGAA
    TTTTTGACTGTCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1335

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MYY_RS06460 [old locus tag: MYY_1262 ]
  • symbol: TrmFO
  • description: methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO
  • length: 444
  • theoretical pI: 4.92503
  • theoretical MW: 49288.7
  • GRAVY: -0.273874

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA:m(5)U-54 methyltransferase (TIGR00137; EC 2.1.1.74; HMM-score: 685)
    and 11 more
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA (TIGR00136; HMM-score: 75.2)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain (TIGR03197; HMM-score: 22.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll geranylgeranyl reductase family (TIGR02032; EC 1.3.1.-; HMM-score: 20.6)
    squalene-associated FAD-dependent desaturase (TIGR03467; HMM-score: 18.1)
    9,9'-di-cis-zeta-carotene desaturase (TIGR02732; EC 1.3.5.6; HMM-score: 17.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine glycine oxidase ThiO (TIGR02352; EC 1.4.3.19; HMM-score: 14.8)
    Unknown function Enzymes of unknown specificity flavoprotein, HI0933 family (TIGR00275; HMM-score: 14.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other phytoene desaturase (TIGR02734; EC 1.14.99.-; HMM-score: 12.2)
    Metabolism Energy metabolism TCA cycle succinate dehydrogenase or fumarate reductase, flavoprotein subunit (TIGR01811; EC 1.3.99.1; HMM-score: 12)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other C-3',4' desaturase CrtD (TIGR02733; EC 1.3.99.-; HMM-score: 11.5)
    putative selenate reductase, YgfK subunit (TIGR03315; HMM-score: 9.7)
  • TheSEED: see MYY_1262
  • PFAM:
    NADP_Rossmann (CL0063) GIDA; Glucose inhibited division protein A (PF01134; HMM-score: 368.2)
    and 7 more
    NAD_binding_8; NAD(P)-binding Rossmann-like domain (PF13450; HMM-score: 20.9)
    FAD_binding_2; FAD binding domain (PF00890; HMM-score: 19.8)
    DAO; FAD dependent oxidoreductase (PF01266; HMM-score: 18.6)
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (PF02737; HMM-score: 17.7)
    HI0933_like; HI0933-like protein (PF03486; HMM-score: 16.9)
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 15.9)
    Amino_oxidase; Flavin containing amine oxidoreductase (PF01593; HMM-score: 14.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9608
    • Cytoplasmic Membrane Score: 0.002
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0372
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.042349
    • TAT(Tat/SPI): 0.005705
    • LIPO(Sec/SPII): 0.009549
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000083726 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSQSYINVIGAGLAGSEAAYQIAERGIPVKLYEMRGVKSTPQHKTDNFAELVCSNSLRGDALTNAVGLLKEEMRRLGSVILESAEATRVPAGGALAVDRDGFSQMVTEKVVNHPLIEVVRDEITELPTDVITVVATGPLTSDALAEKIHALNDGDGFYFYDAAAPIIDVNTIDMSKVYLKSRYDKGEAAYLNAPMTKQEFMDFHEALVNAEEAPLNSFEKEKYFEGCMPIEVMAKRGIKTMLYGPMKPVGLEYPDDYTGPRDGEFKTPYAVVQLRQDNAAGSLYNIVGFQTHLKWGEQKRVFQMIPSLENAEFVRYGVMHRNSYMDSPNLLEQTYRSKKQPNLFFAGQMTGVEGYVESAASGLVAGINAARLFKEESEAIFPDTTAIGSLAHYITHADSKHFQPMNVNFGIIKELEGERIRDKKARYEKIAERALADLEEFLTV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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