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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ST556
  • locus tag: MYY_RS08835 [old locus tag: MYY_1713 ]
  • pan locus tag?: PNEUPAN003330000
  • symbol: trpA
  • pan gene symbol?: trpA
  • synonym:
  • product: tryptophan synthase subunit alpha

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MYY_RS08835 [old locus tag: MYY_1713 ]
  • symbol: trpA
  • product: tryptophan synthase subunit alpha
  • replicon: chromosome
  • strand: -
  • coordinates: 1686295..1687071
  • length: 777
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017769 (1686295..1687071) NCBI
  • BioCyc: MYY_RS08835 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1596 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGCCTAAGACACTAACAAAAAAATTAAATGCTATTAAAGCAGCTGGAAAAGGAATTTTT
    GTTCCCTATATCATGGCTGGTGACCACGAAAAAGGTTTGGATGGTCTTGCTGAAACAATT
    CACTTTTTAGAAGATTTGGGTGTCTCTGCAATTGAAGTGGGTATTCCCTTTTCAGACCCT
    GTTGCAGATGGACCTGTTATCGAAGAAGCTGGCTTGCGCAGTTTAGCCCACGGGACCTCT
    ACCCAGGCTTTAGTTGAAACCTTGAAAACCATTGAAACAGAGATTCCACTGGTCATCATG
    ACCTACTTCAACCCCCTCTTTCAGTACGGTGTGGAGAACTTTGTCAAAGATCTGGCTGAT
    ACAGCTGTGAAGGGCTTGATTATCCCAGACCTGCCTCATGAACATGCCAACTTTGTAGAA
    CCATTTTTGGCAGATACAGATATCGCCTTGATTCCTTTAGTAAGCTTGACCACAGGAATT
    GAGCGCCAGAAAGAGTTGATTGAAGGGGCGGAGGGATTCGTCTATGCCGTTGCCATCAAT
    GGGGTAACAGGGAAATCAGGCAATTACCGTGCAGATTTGGACAAGCACTTGGCGCAACTT
    CATCAAGTGGCCGACATCCCAGTCTTGACAGGTTTTGGTGTATCTAGTCAAGCCGATCTG
    GAACGCTTCAATGCGGTGTCAGATGGTGTTATCGTCGGTTCGAAAATAGTAAAAGCTCTC
    CACCAAGGAGAGCCGATTCAGGACTTTATCAAACAAGCAGTAGCTTACCAAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    777

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MYY_RS08835 [old locus tag: MYY_1713 ]
  • symbol: TrpA
  • description: tryptophan synthase subunit alpha
  • length: 258
  • theoretical pI: 4.67857
  • theoretical MW: 27696.6
  • GRAVY: 0.153876

⊟Function[edit | edit source]

  • reaction:
    EC 4.2.1.20?  ExPASy
    Tryptophan synthase L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Aromatic amino acid family tryptophan synthase, alpha subunit (TIGR00262; EC 4.2.1.20; HMM-score: 202.7)
    and 2 more
    Genetic information processing Protein fate Protein folding and stabilization membrane complex biogenesis protein, BtpA family (TIGR00259; HMM-score: 17)
    Unknown function General hisA/hisF family protein (TIGR00734; HMM-score: 12.9)
  • TheSEED: see MYY_1713
  • PFAM:
    TIM_barrel (CL0036) Trp_syntA; Tryptophan synthase alpha chain (PF00290; HMM-score: 272.4)
    and 1 more
    BtpA; BtpA family (PF03437; HMM-score: 19.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.999
    • Cytoplasmic Membrane Score: 0.0001
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0009
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.013599
    • TAT(Tat/SPI): 0.000441
    • LIPO(Sec/SPII): 0.005336
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001127048 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MPKTLTKKLNAIKAAGKGIFVPYIMAGDHEKGLDGLAETIHFLEDLGVSAIEVGIPFSDPVADGPVIEEAGLRSLAHGTSTQALVETLKTIETEIPLVIMTYFNPLFQYGVENFVKDLADTAVKGLIIPDLPHEHANFVEPFLADTDIALIPLVSLTTGIERQKELIEGAEGFVYAVAINGVTGKSGNYRADLDKHLAQLHQVADIPVLTGFGVSSQADLERFNAVSDGVIVGSKIVKALHQGEPIQDFIKQAVAYQK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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