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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 23-APR-2025
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae TIGR4
- locus tag: SP_RS08990 [old locus tag: SP_1811 ]
- pan locus tag?: PNEUPAN003330000
- symbol: trpA
- pan gene symbol?: trpA
- synonym:
- product: tryptophan synthase subunit alpha
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SP_RS08990 [old locus tag: SP_1811 ]
- symbol: trpA
- product: tryptophan synthase subunit alpha
- replicon: chromosome
- strand: -
- coordinates: 1724432..1725208
- length: 777
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: NC_003028 (1724432..1725208) NCBI
- BioCyc:
- MicrobesOnline: see SP_1811
- PneumoBrowse for strain D39V: SPV_1596 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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721ATGCCTAAGACACTAACAGAAAAATTAAATGCTATTAAAGCAGCTGGAAAAGGAATTTTT
GTTCCCTATATCATGGCTGGTGACCACGAGAAAGGTTTGGACGGTCTTGCTGAAACAATT
CACTTTTTAGAAGATTTGGGTGTCTCTGCAATTGAAGTGGGTATTCCCTTTTCAGACCCT
GTTGCAGATGGACCTGTTATCGAAGAAGCTGGCTTGCGCAGTTTAGCCCACGGGACCTCT
ACCCAGGCTTTAGTTGAAACCTTGAAAACCATTGAAACAGAGATTCCACTGGTCATCATG
ACCTACTTCAACCCCCTCTTTCAGTACGGTGTGGAGAACTTTGTCAAAGATCTGGCTGAT
ACAGCTGTGAAGGGCTTGATTATCCCAGACCTGCCTCATGAACATGCCAACTTTGTAGAA
CCATTTTTGGCAAATACAGATATCGCCTTGATTCCTTTAGTAAGCTTGACCACAGGAATT
GAGCGCCAGAAAGAGTTGATTGAAGGGGCGGAGGGATTCATCTATGCCGTTGCCATCAAT
GGAGTGACAGGGAAATCAGGCAATTACCGTGCAGATTTGGACAAGCACTTGGCGCAACTT
CATCAAGTGGCCGACATCCCAGTCTTGACAGGTTTTGGTGTATCTAGTCAAGCCGATCTG
GAACGCTTCAATGCGGTGTCAGATGGTGTTATCGTCGGTTCGAAAATAGTAAAAGCTCTC
CACCAAGGAGAGCCGATTCAGGATTTTATCAGACAAGCAGTAGCTTACCAAAAATAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SP_RS08990 [old locus tag: SP_1811 ]
- symbol: TrpA
- description: tryptophan synthase subunit alpha
- length: 258
- theoretical pI: 4.60388
- theoretical MW: 27738.6
- GRAVY: 0.154264
⊟Function[edit | edit source]
- reaction: EC 4.2.1.20? ExPASyTryptophan synthase L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O
- TIGRFAM: Amino acid biosynthesis Aromatic amino acid family tryptophan synthase, alpha subunit (TIGR00262; EC 4.2.1.20; HMM-score: 202.4)and 2 moreProtein fate Protein folding and stabilization membrane complex biogenesis protein, BtpA family (TIGR00259; HMM-score: 16.9)Unknown function General hisA/hisF family protein (TIGR00734; HMM-score: 13.6)
- TheSEED: see SP_1811
- PFAM: TIM_barrel (CL0036) Trp_syntA; Tryptophan synthase alpha chain (PF00290; HMM-score: 271.8)and 1 moreBtpA; BtpA family (PF03437; HMM-score: 19.8)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9991
- Cytoplasmic Membrane Score: 0.0001
- Cell wall & surface Score: 0
- Extracellular Score: 0.0008
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.009827
- TAT(Tat/SPI): 0.000435
- LIPO(Sec/SPII): 0.002956
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MPKTLTEKLNAIKAAGKGIFVPYIMAGDHEKGLDGLAETIHFLEDLGVSAIEVGIPFSDPVADGPVIEEAGLRSLAHGTSTQALVETLKTIETEIPLVIMTYFNPLFQYGVENFVKDLADTAVKGLIIPDLPHEHANFVEPFLANTDIALIPLVSLTTGIERQKELIEGAEGFIYAVAINGVTGKSGNYRADLDKHLAQLHQVADIPVLTGFGVSSQADLERFNAVSDGVIVGSKIVKALHQGEPIQDFIRQAVAYQK
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: trpA < trpB < SP_RS09000 < trpC < trpD < SP_RS09015 < trpEStringTie [1] : SP_RS08980 < SP_RS08985 < trpA < trpB < SP_RS09000 < trpC < trpD < SP_RS09015 < trpE < SP_RS13485
⊟Regulation[edit | edit source]
- regulator: T-box(Trp) see SP_1811
⊟Transcription[edit | edit source]
- transcription start site:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_1596 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ 1.0 1.1 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
PLoS Pathog: 2018, 14(12);e1007461
[PubMed:30517198] [WorldCat.org] [DOI] (I e)