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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-JUN-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NCTC7466
  • locus tag: NCTC7466_00141 [new locus tag: DQM66_RS00775 ]
  • pan locus tag?: PNEUPAN000810000
  • symbol: mshA
  • pan gene symbol?: epsF
  • synonym:
  • product: glycosyl transferase, group 1 family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: NCTC7466_00141 [new locus tag: DQM66_RS00775 ]
  • symbol: mshA
  • product: glycosyl transferase, group 1 family protein
  • replicon: chromosome
  • strand: +
  • coordinates: 143060..144265
  • length: 1206
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: LS483374 (143060..144265) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0138 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGCAATATAGTTGTGGAAAAATAAATATTAATATCCCTGATGGATATGGAGACATTAAG
    GATATAGTGTTTTCGGCTCATATTATAGTTAGGTATAATAATGGACATTGTGGAGGTATA
    GATCCGCATATAATTGGACTTTGTAAAAAGCAGATCAGAAGGATGTCTCTATATCCTATT
    TTGATAATCGTATCTAGAGATTCAAAGGTTATTGATGATTATAAAAATTTAGATATTGCC
    TATGTTGATTGTACTCAATGTTCAAATAATTTTGAAACTGCCTTACACGTTAAAAATATT
    TTAAAATTATTAAAAATCCAACTTATACACTGTCATGGCTACTCAACTAATTATTTTTTA
    TATATGTTAAAAAAACTTGACAAGAATGGATTTGGAAAGGTTAAGACAGTGATAACATGC
    CATGGATGGGTTGAATATAACTTAAAAAAGAAATTCTTGACTTATTTTGATTTTTGGACA
    TATTCTATGGGAGATGCTTTTATTTGTGTATCTGAAACTATGAAAAAAAGATTGGAGAGT
    ATAATAAAAAATAAGAAGATAGTTGCAATAAATAACGGAATTAATGTATCAAATAGCGAT
    TTAGATGTAGTAGGTGTTCAAGACTTTAAAAAAGAATTTTGTATTCCAAATAACAAAAAA
    ATCATTTGTTATGTTGGAAGGTTGGATCCAGAAAAAAGGCCGGATAGATTCCTTGAATTT
    GCAGAAAAATTATTTTTAGTCAGAGAAGATGTGATTTTTATTATGGCTGGAAATGGTAGT
    ATGTGGGCTGCTTTGAAAGAAAAAATTTGCCATTTGAAATGTAGAGATAATTTCAGGTTA
    CTTGGTGAAATCTATCCAGCTACTATAGTTTACCAAATATCGGATTTATTGTATATTCCT
    TCTGATACAGAAGGAATACCTATGTGTGTTTTAGAGTCAATGTCACAAGGAACTTCGGTT
    TTAGCTAGTAATGTTGGCGGGTTAAGTGAAATTATTGAACATAGGGTTGATGGATTTTTA
    TTTGAGAAGGAAGATGTTGAGGGAGTGTGTGCTTGTGCTAATTTTTTACTCAATGATTCT
    GAGTATTTGAAATATATAGGTGAGAATAGTAAATCAAAAATAAGAAAACATTTTTCTGTG
    CAAAAAATGTTTGTAGAAACCATGAGAGTATATGATGAATTATTAGAGAAGAGTAGTCAT
    GGATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1206

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: NCTC7466_00141 [new locus tag: DQM66_RS00775 ]
  • symbol: MshA
  • description: glycosyl transferase, group 1 family protein
  • length: 401
  • theoretical pI: 8.04054
  • theoretical MW: 45921.2
  • GRAVY: -0.0870324

⊟Function[edit | edit source]

  • reaction:
    EC 2.4.1.250?  ExPASy
    D-inositol-3-phosphate glycosyltransferase UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Glutathione and analogs N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA (TIGR03999; EC 2.4.1.-; HMM-score: 116.6)
    sugar transferase, PEP-CTERM/EpsH1 system associated (TIGR03088; HMM-score: 103.2)
    and 11 more
    glycosyltransferase, GG-Bacteroidales peptide system (TIGR04157; EC 2.4.1.-; HMM-score: 76.1)
    PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family (TIGR04063; EC 2.4.-.-; HMM-score: 69.9)
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides glycogen synthase, Corynebacterium family (TIGR02149; HMM-score: 68.6)
    D-inositol-3-phosphate glycosyltransferase (TIGR03449; EC 2.4.1.250; HMM-score: 52.2)
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides glycogen/starch synthase, ADP-glucose type (TIGR02095; EC 2.4.1.21; HMM-score: 49.3)
    Unknown function Enzymes of unknown specificity glycosyltransferase, MSMEG_0565 family (TIGR04047; HMM-score: 29.4)
    putative glycosyltransferase, TIGR04348 family (TIGR04348; EC 2.4.1.-; HMM-score: 27.3)
    colanic acid biosynthesis glycosyltransferase WcaL (TIGR04005; EC 2.4.-.-; HMM-score: 27.2)
    sucrose-phosphate synthase, putative, glycosyltransferase domain (TIGR02472; EC 2.4.1.14; HMM-score: 22.9)
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides sucrose synthase (TIGR02470; EC 2.4.1.13; HMM-score: 21.9)
    colanic acid biosynthesis glycosyltransferase WcaI (TIGR04007; EC 2.4.-.-; HMM-score: 20.8)
  • TheSEED: data available for D39, TIGR4
  • PFAM:
    GT-B (CL0113) Glycos_transf_1; Glycosyl transferases group 1 (PF00534; HMM-score: 105.2)
    and 6 more
    Glyco_trans_1_4; Glycosyl transferases group 1 (PF13692; HMM-score: 72.4)
    Glyco_transf_4; Glycosyltransferase Family 4 (PF13439; HMM-score: 60.8)
    Glyco_trans_1_2; Glycosyl transferases group 1 (PF13524; HMM-score: 25.7)
    Glyco_trans_4_4; Glycosyl transferase 4-like domain (PF13579; HMM-score: 20.5)
    Glyco_transf_5; Starch synthase catalytic domain (PF08323; HMM-score: 17.4)
    Glyco_trans_4_2; Glycosyl transferase 4-like (PF13477; HMM-score: 15.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Extracellular
    • Cytoplasmic Score: 0.2493
    • Cytoplasmic Membrane Score: 0.2725
    • Cell wall & surface Score: 0.0004
    • Extracellular Score: 0.4778
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.020149
    • TAT(Tat/SPI): 0.000243
    • LIPO(Sec/SPII): 0.001639
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: SQG01202 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MQYSCGKININIPDGYGDIKDIVFSAHIIVRYNNGHCGGIDPHIIGLCKKQIRRMSLYPILIIVSRDSKVIDDYKNLDIAYVDCTQCSNNFETALHVKNILKLLKIQLIHCHGYSTNYFLYMLKKLDKNGFGKVKTVITCHGWVEYNLKKKFLTYFDFWTYSMGDAFICVSETMKKRLESIIKNKKIVAINNGINVSNSDLDVVGVQDFKKEFCIPNNKKIICYVGRLDPEKRPDRFLEFAEKLFLVREDVIFIMAGNGSMWAALKEKICHLKCRDNFRLLGEIYPATIVYQISDLLYIPSDTEGIPMCVLESMSQGTSVLASNVGGLSEIIEHRVDGFLFEKEDVEGVCACANFLLNDSEYLKYIGENSKSKIRKHFSVQKMFVETMRVYDELLEKSSHG

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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