PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 17-JUN-2018

⊟Summary

• organism: Streptococcus pneumoniae NCTC7466
• locus tag: NCTC7466_00218 [new locus tag: DQM66_RS01175 ]
• pan locus tag^?: PNEUPAN000981000
• symbol: adk
• pan gene symbol^?: adk
• synonym:
• product: adenylate kinase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: NCTC7466_00218 [new locus tag: DQM66_RS01175 ]
• symbol: adk
• product: adenylate kinase
• replicon: chromosome
• strand: +
• coordinates: 207526..208164
• length: 639
• essential: unknown other strains

⊟Accession numbers

• Location: LS483374 (207526..208164) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0214 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  
  ATGAATCTTTTGATTATGGGCTTACCTGGTGCAGGTAAGGGAACTCAAGCAGCAAAAATC
  GTAGAACAATTCCATGTTGCACATATCTCAACAGGTGATATGTTCCGCGCTGCAATGGCA
  AATCAAACTGAAATGGGTGTTCTTGCTAAGTCATATATTGACAAGGGTGAATTGGTTCCT
  GACGAAGTTACAAATGGAATCGTAAAAGAACGCCTTTCACAAGATGATATTAAAGAAACA
  GGATTCTTATTGGATGGTTACCCACGTACAATTGAACAAGCTCATGCCTTGGACAAAACA
  TTGGCTGAACTTGGCATTGAACTAGAAGGTATTATCAATATTGAAGTGAACCCTGACAGC
  CTCTTGGAACGTTTGAGTGGCCGTATCATCCACCGCGTAACTGGAGAAACTTTCCACAAG
  GTCTTTAACCCACCAGTTGACTATAAAGAAGAAGATTACTACCAACGTGAAGATGATAAG
  CCTGAGACAGTAAAACGTCGTTTGGATGTTAATATTGCTCAAGGAGAACCAATCATTGCT
  CACTACCGTGCCAAAGGTTTGGTTCATGACATCGAAGGTAATCAAGATATCAATGATGTC
  TTCTCAGATATTGAAAAAGTATTGACAAATTTGAAATAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  639
  

⊟Protein

⊟General

• locus tag: NCTC7466_00218 [new locus tag: DQM66_RS01175 ]
• symbol: Adk
• description: adenylate kinase
• length: 212
• theoretical pI: 4.72498
• theoretical MW: 23720.7
• GRAVY: -0.387736

⊟Function

• reaction:
  EC 2.7.4.3?  ExPASy
  Adenylate kinase ATP + AMP = 2 ADP
• TIGRFAM:
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions adenylate kinase (TIGR01351; EC 2.7.4.-; HMM-score: 241.4)
  and 7 more
  UMP-CMP kinase family (TIGR01359; EC 2.7.4.-; HMM-score: 131.6)
  adenylate kinase (TIGR01360; EC 2.7.4.3; HMM-score: 117.4)
  putative cytidylate kinase (TIGR02173; EC 2.7.4.14; HMM-score: 25.5)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking signal recognition particle-docking protein FtsY (TIGR00064; HMM-score: 17)
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions cytidylate kinase (TIGR00017; EC 2.7.4.14; HMM-score: 15.7)
  carbohydrate kinase, thermoresistant glucokinase family (TIGR01313; EC 2.7.1.-; HMM-score: 14.8)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking signal recognition particle protein (TIGR00959; HMM-score: 12)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  P-loop_NTPase (CL0023) ADK; Adenylate kinase (PF00406; HMM-score: 187.2)
  and 7 more
  AAA_17; AAA domain (PF13207; HMM-score: 91.5)
  AAA_18; AAA domain (PF13238; HMM-score: 24.3)
  AAA_33; AAA domain (PF13671; HMM-score: 21.7)
  SRP54; SRP54-type protein, GTPase domain (PF00448; HMM-score: 18.6)
  no clan defined ADK_lid; Adenylate kinase, active site lid (PF05191; HMM-score: 13.8)
  P-loop_NTPase (CL0023) Cytidylate_kin; Cytidylate kinase (PF02224; HMM-score: 13.3)
  Thymidylate_kin; Thymidylate kinase (PF02223; HMM-score: 13.1)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.034194
  • TAT(Tat/SPI): 0.002651
  • LIPO(Sec/SPII): 0.002835
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: SQG01278 NCBI
• UniProt:

⊟Protein sequence

• MNLLIMGLPGAGKGTQAAKIVEQFHVAHISTGDMFRAAMANQTEMGVLAKSYIDKGELVPDEVTNGIVKERLSQDDIKETGFLLDGYPRTIEQAHALDKTLAELGIELEGIINIEVNPDSLLERLSGRIIHRVTGETFHKVFNPPVDYKEEDYYQREDDKPETVKRRLDVNIAQGEPIIAHYRAKGLVHDIEGNQDINDVFSDIEKVLTNLK

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0214 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications