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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 08-SEP-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae BM6001
  • locus tag: ODS73_RS06590 [old locus tag: ODS73_06590 ]
  • pan locus tag?: PNEUPAN002516000
  • symbol: topA
  • pan gene symbol?: topA
  • synonym:
  • product: type I DNA topoisomerase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: ODS73_RS06590 [old locus tag: ODS73_06590 ]
  • symbol: topA
  • product: type I DNA topoisomerase
  • replicon: chromosome
  • strand: -
  • coordinates: 1288864..1290951
  • length: 2088
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP107038 (1288864..1290951) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1120 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    GTGGCTACGGCAACAAAAAAGAAAAAATCAACAGTTAAAAAAAATCTAGTCATCGTGGAG
    TCGCCTGCTAAGGCCAAGACGATTGAAAAATATCTAGGCAGAAACTACAAGGTTTTAGCC
    AGTGTCGGGCATATCCGTGATTTGAAGAAATCCAGTATGTCCGTCGATATTGAAAATAAT
    TATGAACCGCAATATATTAATATCCGAGGAAAAGGCCCTCTTATCAATGACTTGAAAAAA
    GAAGCTAAAAAAGCTAATAAAGTTTTTCTCGCGAGTGACCCGGACCGTGAAGGAGAAGCG
    ATTTCTTGGCATTTGGCCCATATTCTCAACTTGGATGAAAATGATGCCAACCGTGTGGTC
    TTCAATGAAATCACCAAGGATGCAGTCAAAAATGCTTTTAAAGAACCTCGTAAGATCGAT
    ATGGACTTGGTCGATGCCCAACAAGCTCGTCGGATCTTGGACCGCTTGGTAGGGTATTCG
    ATTTCGCCTATTTTGTGGAAGAAGGTCAAGAAGGGCTTGTCAGCAGGTCGCGTTCAGTCC
    ATTGCCCTTAAACTCATCATTGACCGTGAAAATGAAATCAATGCCTTCCAGCCAGAAGAA
    TACTGGACAGTTGATGCTGTCTTTAAAAAGGGAACCAAACAATTTCATGCTTCCTTCTAT
    GGAGTAGATGGTAAAAAGATGAAACTGACCAGCAATGACGAAGTCAAGGAAGTCTTGTCT
    CGTCTGACGAGTAAAGACTTTTCAGTAGATCAGGTGGATAAGAAAGAGCGCAAGCGCAAT
    GCTCCTTTACCCTATACCACTTCATCTATGCAGATGGATGCTGCCAATAAAATCAATTTC
    CGTACTCGAAAAACCATGATGGTTGCCCAACAGCTCTATGAAGGAATTAATATCGGTTCT
    GGTGTTCAAGGTTTGATTACCTATATGCGTACCGATTCGACTCGTATCAGTCCTGTAGCG
    CAAAATGAGGTGGCAAGCTTCATTACGGATCGTTTTGGTAGTAAGTATTCTAAGCACGGT
    AGCAAGGTCAAAAACGCATCAGGTGCTCAGGATGCCCATGAGGCTATTCGTCCGTCAAGT
    GTCTTTAATACACCAGAAAGCATCGCTAAGTATCTGGACAAGGATCAGCTCAAGCTATAT
    ACCCTTATCTGGAATCGTTTTGTGGCTAGCCAGATGACAGCGGCCGTTTTTGATACCATG
    GCTGTTAAATTGTCTCAAAAAGGGGTTCAATTTGCTGCCAATGGTAGTCAGGTTAAGTTT
    GATGGTTATCTTGCCATTTATAATGATTCTGACAAGAATAAGATGTTACCGGACATGGTT
    GTTGGAGATGTGGTCAAACAGGTCAATAGCAAACCAGAGCAACATTTCACCCAACCGCCT
    GCCCGTTATTCTGAAGCAACACTGATTAAAACCTTAGAGGAAAATGGGGTTGGACGTCCA
    TCAACCTACGCGCCAACCATTGAAACCATTCAGAAACGTTATTATGTTCGCCTGGCAGCC
    AAACGTTTTGAACCGACAGAGTTGGGAGAAATTGTCAATAAGCTCATCGTTGAATATTTC
    CCAGATATCGTAAACGTGACCTTCACAGCTGAAATGGAAGGTAAACTGGATGATGTCGAA
    GTTGGAAAAGAGCAGTGGCGACGGGTCATTGATGCCTTTTACAAACCATTCTCTAAAGAA
    GTTGCCAAGGCTGAAGAAGAAATGGAAAAAATCCAGATTAAGGATGAACCAGCTGGATTT
    GACTGTGAAGTGTGTGGCAGTCCAATGGTCATTAAACTTGGTCGTTTTGGTAAATTCTAC
    GCTTGTAGCAATTTCCCAGATTGCCGTCATACCCAAGCAATCGTGAAAGAGATTGGTGTT
    GAGTGTCCAAGCTGTCATCAGGGACAAATTATTGAGCGAAAAACCAAGCGTAATCGCCTC
    TTCTATGGTTGCAATCGCTATCCAGAATGTGAATTTACCTCTTGGGACAAGCCTGTTGGT
    CGTGACTGTCCAAAATGTGGCAACTTCCTCATGGAGAAAAAAGTCCGTGGTGGTGGCAAG
    CAGGTTGTTTGTAGCAAAGGCGACTACGAGGAAGAAAAGATTAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2088

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: ODS73_RS06590 [old locus tag: ODS73_06590 ]
  • symbol: TopA
  • description: type I DNA topoisomerase
  • length: 695
  • theoretical pI: 9.6525
  • theoretical MW: 78710.8
  • GRAVY: -0.551079

⊟Function[edit | edit source]

  • reaction:
    EC 5.6.2.1?  ExPASy
    non-specified enzyme name
  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA topoisomerase I (TIGR01051; EC 5.99.1.2; HMM-score: 807.4)
    and 3 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair reverse gyrase (TIGR01054; EC 3.6.4.12,5.99.1.3; HMM-score: 299.3)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA topoisomerase I (TIGR01057; EC 5.99.1.2; HMM-score: 294.2)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA topoisomerase III (TIGR01056; EC 5.99.1.2; HMM-score: 205)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    no clan defined Topoisom_bac; DNA topoisomerase (PF01131; HMM-score: 429.9)
    and 8 more
    Toprim-like (CL0413) Toprim; Toprim domain (PF01751; HMM-score: 106.8)
    Zn_Beta_Ribbon (CL0167) zf-C4_Topoisom; Topoisomerase DNA binding C4 zinc finger (PF01396; HMM-score: 101.9)
    RNA_POL_M_15KD; RNA polymerases M/15 Kd subunit (PF02150; HMM-score: 19.4)
    no clan defined DUF2996; Protein of unknown function (DUF2996) (PF11210; HMM-score: 16.6)
    Zn_Beta_Ribbon (CL0167) Auto_anti-p27; Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) (PF06677; HMM-score: 14.3)
    no clan defined HypA; Hydrogenase/urease nickel incorporation, metallochaperone, hypA (PF01155; HMM-score: 11.3)
    Cys_rich_CPXG; Cysteine-rich CPXCG (PF14255; HMM-score: 10.1)
    Zn_Beta_Ribbon (CL0167) Zn-ribbon_8; Zinc ribbon domain (PF09723; HMM-score: 9.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.7671
    • Cytoplasmic Membrane Score: 0.0039
    • Cell wall & surface Score: 0.0018
    • Extracellular Score: 0.2272
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.015146
    • TAT(Tat/SPI): 0.000814
    • LIPO(Sec/SPII): 0.000969
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000179644 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSSMSVDIENNYEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAISWHLAHILNLDENDANRVVFNEITKDAVKNAFKEPRKIDMDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIIDRENEINAFQPEEYWTVDAVFKKGTKQFHASFYGVDGKKMKLTSNDEVKEVLSRLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEVASFITDRFGSKYSKHGSKVKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMAVKLSQKGVQFAANGSQVKFDGYLAIYNDSDKNKMLPDMVVGDVVKQVNSKPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVRLAAKRFEPTELGEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVEVGKEQWRRVIDAFYKPFSKEVAKAEEEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVECPSCHQGQIIERKTKRNRLFYGCNRYPECEFTSWDKPVGRDCPKCGNFLMEKKVRGGGKQVVCSKGDYEEEKIK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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