PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

⊟Summary

• pan ID^?: PNEUPAN002516000
• symbol^?: topA
• synonym:
• description^?: type I DNA topoisomerase

  descriptions from strain specific annotations:

  • type I DNA topoisomerase
  • DNA topoisomerase I
  • DNA topoisomerase 1
  • Topoisomerase IA
• strand^?: -
• coordinates^?: 3218470..3221983
• occurrence^?: in 100% of 43 strains

⊟Orthologs

(4)^?
TIGR4:
SP_RS06195 (topA)
(2)
D39:
SPD_RS05975 (topA)
(2)
D39V:
SPV_RS05970 (topA)
(19A)
Hungary19A-6:
SPH_RS06675 (topA)
(19F)
EF3030:
EF3030_RS05135 (topA)
(6B)^?
670-6B:
SP670_RS05005 (topA)
(6A)
6A-10:
HKM25_RS05925 (topA)
(5)
70585:
SP70585_RS06590 (topA)
(19F)
A026:
T308_RS04510 (topA)
(3)
A66:
A66_RS05750 (topA)
(11A)
AP200:
SPAP_RS06365 (topA)
(12F)
ASP0581:
EL334_RS06520 (topA)
(19F)
ATCC 49619:
EL263_RS06160 (topA)
(23F)
ATCC 700669:
SPN23F_RS05870 (topA)
(19F)
BM6001:
ODS73_RS06590 (topA)
(1)
BVJ1JL:
JN057_RS06295 (topA)
(14)
CGSP14:
SPCG_RS05400 (topA)
(19F)
G54:
SPG_RS05810 (topA)
(1)
gamPNI0373:
HMPREF1038_RS06220 (topA)
(3)
HU-OH:
EL271_RS06330 (topA)
(19A)
Hu15:
SPNHU15_RS06140 (topA)
(19A)
Hu17:
SPNHU17_RS06065 (topA)
(1)
INV104:
INV104_RS06260 (topA)
(14)
INV200:
SPNINV200_RS05230 (topA)
(14)
JJA:
SPJ_RS05855 (topA)
(19F)
MDRSPN001:
MDRSPN_RS04110 (topA)
(1)
NCTC7465:
AT689_RS07615 (topA)
(2)
NCTC7466:
DQM66_RS05975 (topA)
(4)
NU83127:
EL277_RS06205 (topA)
(3)
OXC141:
SPNOXC_RS06095 (topA)
(1)
P1031:
SPP_RS06435 (topA)
(2)
R6:
SPR_RS05705 (topA)
(19A)
SP49:
BMJ42_RS06645 (topA)
(1)
SPN032672:
SPN032672_RS01130 (topA)
(3)
SPN034156:
SPN034156_RS01150 (topA)
(3)
SPN034183:
SPN034183_RS06110 (topA)
(3)
SPN994038:
SPN994038_RS06015 (topA)
(3)
SPN994039:
SPN994039_RS06020 (topA)
(3)
SPNA45:
SPNA45_RS05205 (topA)
(19F)
ST556:
MYY_RS04985 (topA)
(19F)
Taiwan19F-14:
SPT_RS04770 (topA)
(19A)
TCH8431/19A:
HMPREF0837_RS05935 (topA)
(4)
Xen35:
CXP32_RS06255 (topA)

⊟Genome Viewer

TIGR4
D39
D39V
Hungary19A-6
EF3030

⊟Alignments

• alignment of orthologues:
  CLUSTAL format alignment by MAFFT L-INS-i (v7.505)
  
  
  TIGR4           MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSSMSVDIENN
  D39             MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSSMSVDIENN
  D39V            MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSSMSVDIENN
  Hungary19A-6    MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSSMSVDIENN
  EF3030          MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSSMSVDIENN
                  ************************************************************
  
  TIGR4           YEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAISWHLAHILNLDENDANRVV
  D39             YEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAISWHLAHILNLDENDANRVV
  D39V            YEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAISWHLAHILNLDENDANRVV
  Hungary19A-6    YEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAISWHLAHILNLDENDANRVV
  EF3030          YEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAISWHLAHILNLDENDANRVV
                  ************************************************************
  
  TIGR4           FNEITKDAVKNAFKEPRKIDMDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQS
  D39             FNEITKDAVKNAFKEPRKIDMDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQS
  D39V            FNEITKDAVKNAFKEPRKIDMDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQS
  Hungary19A-6    FNEITKDAVKNAFKEPRKIDMDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQS
  EF3030          FNEITKDAVKNAFKEPRKIDMDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQS
                  ************************************************************
  
  TIGR4           IALKLIIDRENEINAFQPEEYWTVDAVFKKGTKQFHASFYGVDGKKMKLTSNNEVKEVLS
  D39             IALKLIIDRENEINAFQPEEYWTVDAVFKKGTKQFHASFYGVDGKKMKLTSNNEVKEVLS
  D39V            IALKLIIDRENEINAFQPEEYWTVDAVFKKGTKQFHASFYGVDGKKMKLTSNNEVKEVLS
  Hungary19A-6    IALKLIIDRENEINAFQPEEYWTVDAVFKKGTKQFHASFYGVDGKKMKLTSNDEVKEVLS
  EF3030          IALKLIIDRENEINAFQPEEYWTVDAVFKKGTKQFHASFYGVDGKKMKLTSNDEVKEVLS
                  ****************************************************:*******
  
  TIGR4           RLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAANKINFRTRKTMMVAQQLYEGINIGS
  D39             RLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAANKINFRTRKTMMVAQQLYEGINIGS
  D39V            RLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAANKINFRTRKTMMVAQQLYEGINIGS
  Hungary19A-6    RLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAANKINFRTRKTMMVAQQLYEGINIGS
  EF3030          RLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAANKINFRTRKTMMVAQQLYEGINIGS
                  ************************************************************
  
  TIGR4           GVQGLITYMRTDSTRISPVAQNEAASFITDRFGSKYSKHGSKVKNASGAQDAHEAIRPSS
  D39             GVQGLITYMRTDSTRISPVAQNEAASFITDRFGSKYSKHGSKVKNASGAQDAHEAIRPSS
  D39V            GVQGLITYMRTDSTRISPVAQNEAASFITDRFGSKYSKHGSKVKNASGAQDAHEAIRPSS
  Hungary19A-6    GVQGLITYMRTDSTRISPVAQNEVASFITDRFGSKYSKHGSKVKNASGAQDAHEAIRPSS
  EF3030          GVQGLITYMRTDSTRISPVAQNEAASFITDRFGSKYSKHGSKVKNASGAQDAHEAIRPSS
                  ***********************.************************************
  
  TIGR4           VFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMAVKLSQKGVQFAANGSQVKF
  D39             VFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMAVKLSQKGVQFAANGSQVKF
  D39V            VFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMAVKLSQKGVQFAANGSQVKF
  Hungary19A-6    VFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMAVKLSQKGVQFAANGSQVKF
  EF3030          VFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMAVKLSQKGVQFAANGSQVKF
                  ************************************************************
  
  TIGR4           DGYLAIYNDSDKNKMLPDMVVGDVVKQVNSKPEQHFTQPPARYSEATLIKTLEENGVGRP
  D39             DGYLAIYNDSDKNKMLPDMVVGDVVKQVNSKPEQHFTQPPARYSEATLIKTLEENGVGRP
  D39V            DGYLAIYNDSDKNKMLPDMVVGDVVKQVNSKPEQHFTQPPARYSEATLIKTLEENGVGRP
  Hungary19A-6    DGYLAIYNDSDKNKMLPDMVVGDVVKQVNSKPEQHFTQPPARYSEATLIKTLEENGVGRP
  EF3030          DGYLAIYNDSDKNKMLPDMVVGDVVKQVNSKPEQHFTQPPARYSEATLIKTLEENGVGRP
                  ************************************************************
  
  TIGR4           STYAPTIETIQKRYYVRLAAKRFEPTELGEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVE
  D39             STYAPTIETIQKRYYVRLAAKRFEPTELGEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVE
  D39V            STYAPTIETIQKRYYVRLAAKRFEPTELGEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVE
  Hungary19A-6    STYAPTIETIQKRYYVRLAAKRFEPTELGEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVE
  EF3030          STYAPTIETIQKRYYVRLAAKRFEPTELGEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVE
                  ************************************************************
  
  TIGR4           VGKEQWRRVIDAFYKPFSKEVAKAEEEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFY
  D39             VGKEQWRRVIDAFYKPFSKEVAKAEEEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFY
  D39V            VGKEQWRRVIDAFYKPFSKEVAKAEEEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFY
  Hungary19A-6    VGKEQWRRVIDAFYKPFSKEVAKAEEEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFY
  EF3030          VGKEQWRRVIDAFYKPFSKEVAKAEEEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFY
                  ************************************************************
  
  TIGR4           ACSNFPDCRHTQAIVKEIGVECPSCHQGQIIERKTKRNRLFYGCNRYPECEFTSWDKPVG
  D39             ACSNFPDCHHTQAIVKEIGVECPSCHQGQIIERKTKRNRLFYGCNRYPECEFTSWDKPVG
  D39V            ACSNFPDCHHTQAIVKEIGVECPSCHQGQIIERKTKRNRLFYGCNRYPECEFTSWDKPVG
  Hungary19A-6    ACSNFPDCRHTQAIVKEIGVECPSCHQGQIIERKTKRNRLFYGCNRYPECEFTSWDKPVG
  EF3030          ACSNFPDCRHTQAIVKEIGVECPSCHQGQIIERKTKRNRLFYGCNRYPECEFTSWDKPVG
                  ********:***************************************************
  
  TIGR4           RDCPKCGNFLMEKKVRGGGKQVVCSKGDYEEEKMALCQL
  D39             RDCPKCGNFLMEKKVRGGGKQVVCSKGDYEEEKIK----
  D39V            RDCPKCGNFLMEKKVRGGGKQVVCSKGDYEEEKIK----
  Hungary19A-6    RDCPKCGNFLMEKKVRGGGKQVVCSKGDYEEEKIK----
  EF3030          RDCPKCGNFLMEKKVRGGGKQVVCSKGDYEEEKIK----
                  *********************************: