PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

⊟Summary

• pan ID^?: PNEUPAN002292000
• symbol^?: rexA
• synonym: addA
• description^?: helicase-exonuclease AddAB subunit AddA

  descriptions from strain specific annotations:

  • helicase-exonuclease AddAB subunit AddA
  • putative ATP-dependent exonuclease subunit A
  • recombination helicase AddA
  • ATP-dependent helicase/nuclease subunit A
  • exonuclease RexA
  • ATP-dependent exoDNAse subunit beta
  • ATP-dependent helicase
  • ATP-dependent nuclease subunit A
  • ATP-dependent exoDNAse (exonuclease V) beta subunit
  • ATP-dependent nuclease, subunit A
  • ATP-dependent nuclease subunit RexA
  • First subunit of major exonuclease
  • helicase-exonuclease AddAB, AddA subunit
• strand^?: +
• coordinates^?: 2858994..2862644
• occurrence^?: in 100% of 43 strains

⊟Orthologs

(4)^?
TIGR4:
SP_RS05685 (addA)
(2)
D39:
SPD_RS05455 (addA)
(2)
D39V:
SPV_RS04885 (addA)
(19A)
Hungary19A-6:
SPH_RS05945 (addA)
(19F)
EF3030:
EF3030_RS05680 (addA)
(6B)^?
670-6B:
SP670_RS05940 (addA)
(6A)
6A-10:
HKM25_RS05420 (addA)
(5)
70585:
SP70585_RS06000 (addA)
(19F)
A026:
T308_RS05570 (addA)
(3)
A66:
A66_RS05185 (addA)
(11A)
AP200:
SPAP_RS05240 (addA)
(12F)
ASP0581:
EL334_RS05595 (addA)
(19F)
ATCC 49619:
EL263_RS05640 (addA)
(23F)
ATCC 700669:
SPN23F_RS05365 (addA)
(19F)
BM6001:
ODS73_RS05755 (addA)
(1)
BVJ1JL:
JN057_RS05765 (addA)
(14)
CGSP14:
SPCG_RS05935 (addA)
(19F)
G54:
SPG_RS05300 (addA)
(1)
gamPNI0373:
HMPREF1038_RS05150 (addA)
(3)
HU-OH:
EL271_RS05435 (addA)
(19A)
Hu15:
SPNHU15_RS05450 (addA)
(19A)
Hu17:
SPNHU17_RS05375 (addA)
(1)
INV104:
INV104_RS05755 (addA)
(14)
INV200:
SPNINV200_RS05750 (addA)
(14)
JJA:
SPJ_RS05355 (addA)
(19F)
MDRSPN001:
MDRSPN_RS05130 (addA)
(1)
NCTC7465:
AT689_RS08165 (addA)
(2)
NCTC7466:
DQM66_RS04895 (addA)
(4)
NU83127:
EL277_RS05695 (addA)
(3)
OXC141:
SPNOXC_RS05590 (addA)
(1)
P1031:
SPP_RS05645 (addA)
(2)
R6:
SPR_RS05190 (addA)
(19A)
SP49:
BMJ42_RS06130 (addA)
(1)
SPN032672:
SPN032672_RS00625 (addA)
(3)
SPN034156:
SPN034156_RS00645 (addA)
(3)
SPN034183:
SPN034183_RS05610 (addA)
(3)
SPN994038:
SPN994038_RS05515 (addA)
(3)
SPN994039:
SPN994039_RS05520 (addA)
(3)
SPNA45:
SPNA45_RS07985 (addA)
(19F)
ST556:
MYY_RS06050 (addA)
(19F)
Taiwan19F-14:
SPT_RS05840 (addA)
(19A)
TCH8431/19A:
HMPREF0837_RS06445 (addA)
(4)
Xen35:
CXP32_RS05730 (addA)

⊟Genome Viewer

TIGR4
D39
D39V
Hungary19A-6
EF3030

⊟Alignments

• alignment of orthologues:
  CLUSTAL format alignment by MAFFT L-INS-i (v7.505)
  
  
  TIGR4           MKLIPFLSEEEIQKLQEAEANSSKEQKKTAEQIEAIYTSAQNILVSASAGSGKTFVMAER
  D39             MKLIPFLSEEEIQKLQEAEANSSKEQKKTAEQIEAIYTSAQNILVSASAGSGKTFVMAER
  D39V            MKLIPFLSEEEIQKLQEAEANSSKEQKKTAEQIEAIYTSAQNILVSASAGSGKTFVMAER
  Hungary19A-6    MKLIPFLSEEEIQKLQEAEANSSKEQKKTAEQIEAIYTSGQNILVSASAGSGKTFVMAER
  EF3030          MKLIPFLSEEEIQKLQEAEANSSKEQKKTAEQIEAIYTSGQNILVSASAGSGKTFVMAER
                  ***************************************.********************
  
  TIGR4           ILDQLARGVEISQLFISTFTVKAATELKERLEKKISKKIQETDDVDLKQHLGRQLADLPN
  D39             ILDQLARGVEISQLFISTFTVKAATELKERLEKKISKKIQETDDVDLKQHLGRQLADLPN
  D39V            ILDQLARGVEISQLFISTFTVKAATELKERLEKKISKKIQETDDVDLKQHLGRQLADLPN
  Hungary19A-6    ILDQLARGVEISQLFISTFTVKAANELKERLEKKISKKIQETDDVDLKQHLGRQLADLPN
  EF3030          ILDQLARGVEISQLFISTFTVKAATELKERLEKKISKKIQETDDVDLKQHLGRQLADLPN
                  ************************.***********************************
  
  TIGR4           AAIGTMDSFTQKFLGKHGYLLDIAPNFRILQNQSEQLILENEVFHEVFEAHYQGKQKETF
  D39             AAIGTMDSFTQKFLGKHGYLLDIAPNFRILQNQSEQLILENEVFHEVFEAHYQGKQKETF
  D39V            AAIGTMDSFTQKFLGKHGYLLDIAPNFRILQNQSEQLILENEVFHEVFEAHYQGKQKETF
  Hungary19A-6    AAIGTMDSFTQKFLGKHGYLLDIAPNFRILQNQSEQLLLENEVFHEVFEAHYQGKQKETF
  EF3030          AAIGTMDSFTQKFLGKHGYLLDIAPNFRILQNQSEQLLLENEVFHEVFEAHYQGKQKETF
                  *************************************:**********************
  
  TIGR4           SHLLKNFAGRGKDERGLRQQVYKIYDFLQSTSNPQKWLSESFLKGFEKADFTSEKEKLTE
  D39             SHLLKNFAGRGKDERGLRQQVYKIYDFLQSTSNPQKWLSESFLKGFEKADFTSEKEKLTE
  D39V            SHLLKNFAGRGKDERGLRQQVYKIYDFLQSTSNPQKWLSESFLKGFEKADFTSEKEKLTE
  Hungary19A-6    SHLLKNFAGRGKDERGLRQQVYKIYDFLQSTSNPQKWLSDSFLKGFEKADFTSEKEKLTE
  EF3030          SHLLKNFAGRGKDERGLRQQVYKIYDFLQSTSNPQKWLSKSFLKGFEKADFTSEKEKLTE
                  ***************************************.********************
  
  TIGR4           QIKQALWDLESFFRYHLDNDAKEFAKAAYLENVQLILDEIGSLNQESDSQAYQAVLARVV
  D39             QIKQALWDLESFFRYHLDNDAKEFAKAAYLENVQLILDEIGSLNQESDSQAYQAVLARVV
  D39V            QIKQALWDLESFFRYHLDNDAKEFAKAAYLENVQLILDEIGSLNQESDSQAYQAVLARVV
  Hungary19A-6    QIKQALWDLESFFRYHLDNDAKEFAKAAYLENVQLILDEIGSLNQESDSQAYQAVLAHVV
  EF3030          QIKQALWDLESFFRYHLDNDAKEFAKAAYLENVQLILDEIDSLNQESDSQAYQAVLARVV
                  ****************************************.****************:**
  
  TIGR4           AISKEKNGRALTNASRKADLKPLADAYNEERKTQFAKLGQLSDQIAILDYQERYHGDTWK
  D39             AISKEKNGRALTNASRKADLKPLADAYNEERKTQFAKLGQLSDQIAILDYQERYHGDTWK
  D39V            AISKEKNGRALTNASRKADLKPLADAYNEERKTQFAKLGQLSDQIAILDYQERYHGDTWK
  Hungary19A-6    AISKEKNGRALTNASRKADLKPLADAYNEERKTQFAKLGQLSDQITILDYQERYHGDTWK
  EF3030          AISKEKNGRALTNASRKADLKPLADTYNEERKTQFAKLGQLSDQIAILDYQERYHGDTWK
                  *************************:*******************:**************
  
  TIGR4           LAKTFQSFMSDFVEAYRQRKRQENAFEFADISHYTIEILENFPQVRESYQERFHEVMVDE
  D39             LAKTFQSFMSDFVEAYRQRKRQENAFEFADISHYTIEILENFPQVRESYQERFHEVMVDE
  D39V            LAKTFQSFMSDFVEAYRQRKRQENAFEFADISHYTIEILENFPQVRESYQERFHEVMVDE
  Hungary19A-6    LAKTFQSFMSDFVEAYRQRKRQENAFEFADISHYTIEILENFPQVRESYQERFHEVMVDE
  EF3030          LAKTFQSFMSDFVEAYRQRKRQENAFEFADISHYTIEILENFPQVRESYQERFHEVMVDE
                  ************************************************************
  
  TIGR4           YQDTNHIQERMLELLSNGHNRFMVGDIKQSIYRFRQADPQIFNEKFQRYAQNPQEGRLII
  D39             YQDTNHIQERMLELLSNGHNRFMVGDIKQSIYRFRQADPQIFNEKFQRYAQNPQEGRLII
  D39V            YQDTNHIQERMLELLSNGHNRFMVGDIKQSIYRFRQADPQIFNEKFQRYAQNPQEGRLII
  Hungary19A-6    YQDTNHIQERMLELLSNGHNRFMVGDIKQSIYRFRQADPQIFNEKFQRYAQNPQEGKLIL
  EF3030          YQDTNHIQERMLELLSNGHNRFMVGDIKQSIYRFRQADPQIFNEKFQRYAQNPQEGKLIL
                  ********************************************************:**:
  
  TIGR4           LKENFRSSSEVLSATNDVFERLMDQEVGEINYDNKHQLVFANTKLTPNPDNKAAFLLYDK
  D39             LKENFRSSSEVLSATNDVFERLMDQEVGEINYDNKHQLVFANTKLTPNPDNKAAFLLYDK
  D39V            LKENFRSSSEVLSATNDVFERLMDQEVGEINYDNKHQLVFANTKLTPNPDNKAAFLLYDK
  Hungary19A-6    LKENFRSSSEVLSATNDVFERLMDQEVGEINYDNKHQLVFANTKLTPNPDNKAEFLLYDK
  EF3030          LKENFRSSSEVLSATNDVFERLMDQEVGEINYDNKHQLVFANTKLTPNPDNKAEFLLYDK
                  ***************************************************** ******
  
  TIGR4           DDTGEEEESQTETKLTGEMRLVIKEILKLHQEKGVAFKEIALLTSSRSRNDQILLALSEY
  D39             DDTGEEEESQTETKLTGEMRLVIKEILKLHQEKGVAFKEIALLTSSRSRNDQILLALSEY
  D39V            DDTGEEEESQTETKLTGEMRLVIKEILKLHQEKGVAFKEIALLTSSRSRNDQILLALSEY
  Hungary19A-6    DDTGEEEESQTETKLTGEMRLVIKEILKLHQEKGVAFKEIALLTSSRSRNDQILLALSEY
  EF3030          DDTGEEEESQTETKLTGEMRLVIKEILKLHQEKGVAFKEIALLTSSRNRNDQILLALSEY
                  ***********************************************.************
  
  TIGR4           GIPVKTDGEQNNYLQSLEVQVMLDTLRVIHNPLQDYALVALMKSPMFGFDEDELARLSLQ
  D39             GIPVKTDGEQNNYLQSLEVQVMLDTLRVIHNPLQDYALVALMKSPMFGFDEDELARLSLQ
  D39V            GIPVKTDGEQNNYLQSLEVQVMLDTLRVIHNPLQDYALVALMKSPMFGFDEDELARLSLQ
  Hungary19A-6    GIPVKTDGEQNNYLQSLEVQVMLDTLRVIHNPLQDYALVALMKSPMFGFDEDELARLSLQ
  EF3030          GIPVKTDGEQNNYLQSLEVQVMLDTLRVIHNPLQDYALVALMKSPMFGFDEDELARLSLQ
                  ************************************************************
  
  TIGR4           KAEDKVHENLYEKLVNAQKMASSQKGLIHTALAEKLKQFMDILASWRLYAKTHSLYDLIW
  D39             KAEDKVHENLYEKLVNAQKMASSQKGLIHTALAEKLKQFMDILASWRLYAKTHSLYDLIW
  D39V            KAEDKVHENLYEKLVNAQKMASSQKGLIHTALAEKLKQFMDILASWRLYAKTHSLYDLIW
  Hungary19A-6    KAEDKVHENLYEKLVNAQKMASSQKGLIHTALAEKLKQFMDILASWRLYAKTHSLYDLIW
  EF3030          KAEDKAHENLYEKLVNAQKKASSQKGLIHTALAEKLKQFMDILASWRLYAKPHSLYDLIW
                  *****.************* *******************************.********
  
  TIGR4           KIYNDRFYYDYVGALPNGPARQANLYALALRADQFEKSNFKGLSRFIRMIDQVLEAQHDL
  D39             KIYNDRFYYDYVGALPNGPARQANLYALALRADQFEKSNFKGLSRFIRMIDQVLEAQHDL
  D39V            KIYNDRFYYDYVGALPNGPARQANLYALALRADQFEKSNFKGLSRFIRMIDQVLEAQHDL
  Hungary19A-6    KIYNDRFYYDYVGALPNGPARQANLYALALRADQFEKSNFKGLPRFIRMIDQVLEAQHDL
  EF3030          KIYNDRFYYDYVGALPNGPARQANLYALALRADQFEKSNFKGLSRFIRMIDQVLEAQHDL
                  *******************************************.****************
  
  TIGR4           ASVAVAPPKDAVELMTIHKSKGLEFPYVFILNMDQDFNKQDSMSEVILSRQNGLGVKYIA
  D39             ASVAVAPPKDAVELMTIHKSKGLEFPYVFILNMDQDFNKQDSMSEVILSRQNGLGVKYIA
  D39V            ASVAVAPPKDAVELMTIHKSKGLEFPYVFILNMDQDFNKQDSMSEVILSRQNGLGVKYIA
  Hungary19A-6    ASVVVAPPKDAVELMTIHKSKGLEFPYVFILNMDQDFNKQDSMSEVILSRQNGLGVKYIA
  EF3030          ASVAVAPPKDAVELMTIHKSKGLEFPYVFILNMDQDFNKQDSMSEVILSRQNGLGVKYIA
                  ***.********************************************************
  
  TIGR4           KMETGAVEDHYPKTIKLSIPSLTYRQNEEELQLASYSEQMRLLYVAMTRAEKKLYLVGKG
  D39             KMETGAVEDHYPKTIKLSIPSLTYRQNEEELQLASYSEQMRLLYVAMTRAEKKLYLVGKG
  D39V            KMETGAVEDHYPKTIKLSIPSLTYRQNEEELQLASYSEQMRLLYVAMTRAEKKLYLVGKG
  Hungary19A-6    KMETGAVEDHYPKTIKLSIPSLTYRQNEEELQLASYSEQMRLLYVAMTRAEKKLYLVGKG
  EF3030          KMETGAVEDHYPKTIKLSIPSLTYRQNEEELQLASYSEQMRLLYVAMTRAEKKLYLVGKG
                  ************************************************************
  
  TIGR4           SREKLESKEYPAAKNGKLNSNTRLQARNFQDWLWAISKVFTKDKLNFSYRFIGEDQLTRE
  D39             SREKLESKEYPAAKNGKLNSNTRLQARNFQDWLWAISKVFTKDKLNFSYRFIGEDQLTRE
  D39V            SREKLESKEYPAAKNGKLNSNTRLQARNFQDWLWAISKVFTKDKLNFSYRFIGEDQLTRE
  Hungary19A-6    SREKLESKEYPAAKNGKLNSNTRLQARNFQDWLWAISKVFTKDKLNFSYRFIGEDQLTRE
  EF3030          SREKLEAKQYPAAKNGKLNSNTRLQARNFQDWLWAISKVFTKDKLNFSYRFIGEDQLTRE
                  ******:*:***************************************************
  
  TIGR4           AIGELETKSPLQDSSQADNRQSDTIKEALEMLKEVEVYNTLHRAAIELPSVQTPSQIKKF
  D39             AIGELETKSPLQDSSQADNRQSDTIKEALEMLKEVEVYNTLHRAAIELPSVQTPSQIKKF
  D39V            DIGELETKSPLQDSSQADNRQSDTIKEALEMLKEVEVYNTLHRAAIELPSVQTPSQIKKF
  Hungary19A-6    AIGELETKSPLQDSSQADNRQSDTIKEALEMLKEVEVYNTLHRAAIELPSVQTPSQIKKF
  EF3030          AIGELETKSPLRDSSQADNRQSDTIKEALEMLKEVEVYNTLHRAAIELPSVQTPSQIKKF
                   **********:************************************************
  
  TIGR4           YEPVMDMEGVEIAGQGQSVGKKISFDLPDFSTKEKVTGAEIGSATHELMQRIDLSQQLTL
  D39             YEPVMDMEGVEIAGQGQSVGKKISFDLPDFSTKEKVTGAEIGSATHELMQRIDLSQQLTL
  D39V            YEPVMDMEGVEIAGQGQSVGKKISFDLPDFSTKEKVTGAEIGSATHELMQRIDLSQQLTL
  Hungary19A-6    YEPVMDMEGVEIAGQGQSVGKKISFDLPDFSTKEKVTGAEIGSATHELMQRIDLSQQLTL
  EF3030          YEPVMDMEGVEIAGQGQSVGKKISFDLPDFSTKEKVTGAEIGSATHELMQRIDLSQQLTL
                  ************************************************************
  
  TIGR4           ASLTETLKQVQTSQAVRDKINLDKILAFFDTVLGQEILANTDHLYREQPFSMLKRDQKSQ
  D39             ASLTETLKQVQTSQAVRDKINLDKILAFFDTVLGQEILANTDHLYREQPFSMLKRDQKSQ
  D39V            ASLTETLKQVQTSQAVRDKINLDKILAFFDTVLGQEILANTDHLYREQPFSMLKRDQKSQ
  Hungary19A-6    ASLTETLKQVQTSQAVRDKINLDKILAFFDTVLGQEILANTDHLYREQPFSMLKRDQKSQ
  EF3030          ASLTETLKQVQTSQAVRDKINLDKILAFFDTVLGQEILANTDHLYREQPFSMLKRDQKSQ
                  ************************************************************
  
  TIGR4           EDFVVRGILDGYLLYENKIVLFDYKTDRYDEPSQLVDRYRGQLALYEEALSRAYSIENIE
  D39             EDFVVRGILDGYLLYENKIVLFDYKTDRYDEPSQLVDRYRGQLALYEEALSRAYSIENIE
  D39V            EDFVVRGILDGYLLYENKIVLFDYKTDRYDEPSQLVDRYRGQLALYEEALSRAYSIENIE
  Hungary19A-6    EDFVVRGILDGYLLYENKIVLFDYKTDRYDEPSQLVDRYRGQLALYEEALSRAYSIENIE
  EF3030          EDFVVRGILDGYLLYENKIVLFDYKTDRYDEPSQLVDRYRGQLALYEEALSRAYSIKNIE
                  ********************************************************:***
  
  TIGR4           KYLILLGKDEVQVVKV
  D39             KYLILLGKDEVQVVKV
  D39V            KYLILLGKDEVQVVKV
  Hungary19A-6    KYLILLGKDEVQVVKV
  EF3030          KYLILLGKDEVQVVKV
                  ****************