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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NCTC7466
  • locus tag: DQM66_RS04895 [old locus tag: NCTC7466_00939 ]
  • pan locus tag?: PNEUPAN002292000
  • symbol: addA
  • pan gene symbol?: rexA
  • synonym:
  • product: helicase-exonuclease AddAB subunit AddA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: DQM66_RS04895 [old locus tag: NCTC7466_00939 ]
  • symbol: addA
  • product: helicase-exonuclease AddAB subunit AddA
  • replicon: chromosome
  • strand: -
  • coordinates: 928684..932334
  • length: 3651
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_LS483374 (928684..932334) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1016 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    3301
    3361
    3421
    3481
    3541
    3601
    ATGAAGCTTATTCCCTTTTTAAGTGAGGAGGAGATTCAAAAACTGCAAGAAGCAGAAGCA
    AATTCGAGCAAGGAACAGAAGAAAACTGCCGAGCAAATCGAAGCTATCTACACTTCTGCC
    CAGAATATCCTGGTCTCAGCATCGGCTGGTTCTGGAAAGACCTTTGTCATGGCAGAGCGC
    ATTCTGGACCAATTGGCGCGTGGTGTCGAAATTTCTCAACTCTTTATCTCAACCTTTACC
    GTCAAGGCTGCAACTGAACTTAAAGAACGTTTAGAGAAAAAAATCAGCAAGAAAATCCAA
    GAAACAGATGATGTCGACCTCAAACAACACTTGGGTCGCCAGTTGGCAGACCTACCCAAC
    GCTGCCATTGGAACCATGGATTCTTTCACACAAAAATTCCTTGGCAAACATGGTTATCTG
    CTTGATATTGCACCTAATTTCCGTATTTTACAAAACCAAAGCGAGCAACTTATTCTCGAA
    AACGAAGTCTTTCATGAGGTCTTTGAAGCGCATTACCAAGGTAAACAGAAAGAGACCTTT
    AGTCATTTGCTGAAAAACTTTGCTGGGCGTGGCAAGGACGAACGGGGTCTGCGCCAGCAG
    GTCTATAAAATCTATGACTTCCTCCAATCCACCAGTAATCCTCAAAAGTGGCTGAGTGAA
    TCTTTCCTCAAAGGATTTGAGAAAGCTGATTTTACCAGTGAAAAAGAAAAACTGACCGAG
    CAAATCAAACAAGCCCTTTGGGATTTGGAAAGCTTTTTCCGTTACCATCTGGATAACGAT
    GCCAAGGAGTTTGCAAAGGCTGCCTATTTAGAAAATGTTCAGTTAATTCTGGATGAAATT
    GGCTCCCTAAATCAGGAGTCCGATAGTCAGGCTTATCAGGCAGTGCTTGCGCGTGTTGTC
    GCCATCTCTAAGGAGAAAAACGGTCGAGCTCTGACTAATGCCAGCCGTAAGGCTGATTTG
    AAGCCCCTGGCTGATGCCTACAACGAAGAGAGAAAGACCCAGTTTGCTAAACTAGGACAA
    TTATCAGACCAGATAGCGATTCTCGACTATCAAGAACGTTATCATGGAGACACTTGGAAA
    CTAGCTAAAACCTTCCAATCTTTCATGAGCGATTTTGTAGAGGCTTATCGTCAGAGAAAA
    CGACAGGAAAATGCCTTTGAATTCGCTGATATCAGCCATTACACCATTGAGATTTTAGAG
    AATTTCCCACAAGTTCGTGAGTCTTATCAGGAGCGCTTCCATGAAGTCATGGTCGATGAG
    TATCAGGATACCAACCATATTCAAGAACGGATGCTGGAATTGTTGTCTAATGGCCACAAT
    CGCTTTATGGTGGGAGATATCAAGCAATCCATCTATCGTTTCCGTCAGGCAGACCCGCAG
    ATTTTCAATGAGAAATTCCAACGCTATGCGCAAAATCCCCAAGAAGGCAGGCTCATTATC
    CTCAAGGAAAATTTCCGTAGTAGTTCAGAAGTGCTGTCAGCAACCAATGATGTCTTTGAA
    CGTCTCATGGACCAAGAGGTCGGCGAAATCAACTATGATAACAAGCACCAGCTTGTTTTT
    GCCAATACCAAACTGACTCCCAATCCAGACAACAAGGCAGCATTTCTCCTCTACGACAAG
    GACGATACAGGTGAGGAAGAAGAGAGTCAAACAGAAACGAAACTAACAGGCGAAATGCGC
    TTAGTTATCAAGGAGATTCTGAAACTTCATCAAGAAAAAGGTGTTGCCTTTAAGGAAATT
    GCCCTTCTGACCTCCAGCCGCAGTCGTAATGACCAGATTCTCCTCGCCCTGTCTGAGTAC
    GGAATTCCTGTCAAAACTGACGGAGAGCAAAACAATTATCTCCAATCCCTAGAAGTGCAA
    GTCATGCTAGACACTCTTCGTGTCATTCACAATCCCCTGCAAGACTACGCCTTGGTTGCC
    CTTATGAAGTCTCCAATGTTTGGTTTTGATGAGGATGAGCTAGCACGTTTGTCCCTTCAG
    AAAGCAGAGGATAAAGTCCACGAAAATCTCTATGAGAAACTGGTCAATGCACAAAAAATG
    GCAAGTAGTCAAAAAGGCTTGATTCACACAGCTCTAGCTGAAAAACTAAAGCAATTCATG
    GATATCCTAGCTTCTTGGCGCTTGTATGCCAAAACCCACTCTCTCTATGACTTGATTTGG
    AAGATTTACAACGACCGTTTTTATTATGACTATGTTGGGGCTTTGCCGAATGGTCCTGCT
    AGGCAGGCCAATCTCTATGCCCTAGCACTGCGTGCTGATCAATTTGAAAAGAGCAATTTC
    AAAGGTTTGTCGCGTTTTATTCGTATGATTGACCAAGTCTTAGAAGCCCAGCACGATTTG
    GCAAGCGTGGCCGTCGCACCGCCAAAAGATGCAGTAGAGCTCATGACCATCCACAAGAGT
    AAAGGGCTGGAGTTTCCTTACGTCTTTATCCTCAATATGGATCAAGATTTCAACAAGCAA
    GACTCTATGTCAGAAGTCATTCTCAGTCGTCAGAATGGTCTTGGTGTCAAATATATTGCC
    AAGATGGAGACAGGGGCAGTAGAAGACCACTATCCTAAAACCATCAAACTCTCCATTCCT
    AGTCTGACCTATAGGCAGAACGAAGAGGAATTACAGCTAGCAAGCTATTCTGAGCAGATG
    CGTTTGCTGTATGTTGCTATGACGCGGGCTGAGAAAAAGCTCTATCTTGTCGGCAAGGGT
    TCTCGTGAAAAGCTGGAATCCAAGGAATACCCAGCAGCCAAAAATGGGAAACTAAATAGC
    AATACTAGACTGCAAGCACGGAATTTCCAAGATTGGCTTTGGGCTATCAGTAAAGTGTTT
    ACTAAGGACAAGCTCAACTTTAGTTATCGTTTTATTGGCGAAGATCAGTTGACCAGAGAA
    GCTATCGGAGAGTTGGAAACCAAGAGTCCTCTCCAAGATAGCTCCCAAGCAGACAATCGT
    CAGTCAGATACCATCAAAGAAGCTCTGGAAATGCTGAAGGAGGTGGAAGTTTATAATACT
    CTTCACCGCGCAGCTATTGAACTTCCTAGTGTTCAAACCCCAAGTCAAATCAAGAAATTC
    TACGAACCAGTTATGGATATGGAAGGTGTCGAGATTGCTGGTCAAGGTCAGTCAGTAGGC
    AAGAAAATCAGCTTCGATTTGCCAGATTTTTCAACCAAAGAAAAGGTAACTGGAGCTGAG
    ATTGGTAGTGCTACTCACGAACTCATGCAGAGAATTGACCTCAGCCAGCAACTAACCCTT
    GCTAGCCTAACAGAAACACTCAAACAAGTTCAAACTAGCCAAGCTGTCAGAGACAAGATC
    AATCTTGATAAAATTCTTGCTTTCTTTGACACAGTACTCGGTCAGGAAATTCTTGCTAAT
    ACCGACCATCTTTATCGCGAGCAACCTTTCTCCATGCTCAAACGAGACCAAAAGAGTCAG
    GAAGACTTTGTTGTCCGTGGTATCCTTGATGGCTATCTGCTTTACGAAAACAAAATTGTT
    CTGTTCGACTACAAGACAGACCGCTATGATGAACCAAGTCAACTCGTAGACCGCTATCGT
    GGTCAGTTAGCTCTATACGAAGAGGCTTTATCACGAGCCTATTCGATTGAAAATATTGAA
    AAATACTTGATTTTACTCGGTAAAGACGAGGTTCAAGTTGTAAAAGTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2880
    2940
    3000
    3060
    3120
    3180
    3240
    3300
    3360
    3420
    3480
    3540
    3600
    3651

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: DQM66_RS04895 [old locus tag: NCTC7466_00939 ]
  • symbol: AddA
  • description: helicase-exonuclease AddAB subunit AddA
  • length: 1216
  • theoretical pI: 5.39679
  • theoretical MW: 140166
  • GRAVY: -0.541118

⊟Function[edit | edit source]

  • reaction:
    EC 3.6.4.12?  ExPASy
    DNA helicase ATP + H2O = ADP + phosphate
  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair helicase-exonuclease AddAB, AddA subunit (TIGR02785; EC 3.1.-.-,3.6.4.12; HMM-score: 1456.8)
    and 7 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair double-strand break repair helicase AddA (TIGR02784; HMM-score: 209.8)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair ATP-dependent DNA helicase PcrA (TIGR01073; EC 3.6.4.12; HMM-score: 208.5)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA helicase II (TIGR01075; EC 3.6.4.12; HMM-score: 183.7)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair ATP-dependent DNA helicase Rep (TIGR01074; EC 3.6.4.12; HMM-score: 163.4)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair exodeoxyribonuclease V, beta subunit (TIGR00609; EC 3.1.11.5; HMM-score: 162.8)
    Signal transduction Regulatory functions DNA interactions TyrR family helix-turn-helix domain (TIGR04381; HMM-score: 14.2)
    Cellular processes Cellular processes Conjugation P-type conjugative transfer ATPase TrbB (TIGR02782; HMM-score: 12)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    P-loop_NTPase (CL0023) UvrD-helicase; UvrD/REP helicase N-terminal domain (PF00580; HMM-score: 262.9)
    and 13 more
    UvrD_C; UvrD-like helicase C-terminal domain (PF13361; HMM-score: 121.1)
    AAA_19; AAA domain (PF13245; HMM-score: 70.3)
    UvrD_C_2; UvrD-like helicase C-terminal domain (PF13538; HMM-score: 52.3)
    AAA_12; AAA domain (PF13087; HMM-score: 30.5)
    PDDEXK (CL0236) PDDEXK_1; PD-(D/E)XK nuclease superfamily (PF12705; HMM-score: 23.4)
    P-loop_NTPase (CL0023) Viral_helicase1; Viral (Superfamily 1) RNA helicase (PF01443; HMM-score: 20.1)
    DEAD; DEAD/DEAH box helicase (PF00270; HMM-score: 19.3)
    AAA_30; AAA domain (PF13604; HMM-score: 18.6)
    AAA_7; P-loop containing dynein motor region (PF12775; HMM-score: 15.3)
    KdpD; Osmosensitive K+ channel His kinase sensor domain (PF02702; HMM-score: 15.2)
    AAA_22; AAA domain (PF13401; HMM-score: 12.4)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 8.7)
    PhoH; PhoH-like protein (PF02562; HMM-score: 7.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9415
    • Cytoplasmic Membrane Score: 0.0306
    • Cell wall & surface Score: 0.0099
    • Extracellular Score: 0.0179
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.010179
    • TAT(Tat/SPI): 0.006134
    • LIPO(Sec/SPII): 0.000986
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000767212 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKLIPFLSEEEIQKLQEAEANSSKEQKKTAEQIEAIYTSAQNILVSASAGSGKTFVMAERILDQLARGVEISQLFISTFTVKAATELKERLEKKISKKIQETDDVDLKQHLGRQLADLPNAAIGTMDSFTQKFLGKHGYLLDIAPNFRILQNQSEQLILENEVFHEVFEAHYQGKQKETFSHLLKNFAGRGKDERGLRQQVYKIYDFLQSTSNPQKWLSESFLKGFEKADFTSEKEKLTEQIKQALWDLESFFRYHLDNDAKEFAKAAYLENVQLILDEIGSLNQESDSQAYQAVLARVVAISKEKNGRALTNASRKADLKPLADAYNEERKTQFAKLGQLSDQIAILDYQERYHGDTWKLAKTFQSFMSDFVEAYRQRKRQENAFEFADISHYTIEILENFPQVRESYQERFHEVMVDEYQDTNHIQERMLELLSNGHNRFMVGDIKQSIYRFRQADPQIFNEKFQRYAQNPQEGRLIILKENFRSSSEVLSATNDVFERLMDQEVGEINYDNKHQLVFANTKLTPNPDNKAAFLLYDKDDTGEEEESQTETKLTGEMRLVIKEILKLHQEKGVAFKEIALLTSSRSRNDQILLALSEYGIPVKTDGEQNNYLQSLEVQVMLDTLRVIHNPLQDYALVALMKSPMFGFDEDELARLSLQKAEDKVHENLYEKLVNAQKMASSQKGLIHTALAEKLKQFMDILASWRLYAKTHSLYDLIWKIYNDRFYYDYVGALPNGPARQANLYALALRADQFEKSNFKGLSRFIRMIDQVLEAQHDLASVAVAPPKDAVELMTIHKSKGLEFPYVFILNMDQDFNKQDSMSEVILSRQNGLGVKYIAKMETGAVEDHYPKTIKLSIPSLTYRQNEEELQLASYSEQMRLLYVAMTRAEKKLYLVGKGSREKLESKEYPAAKNGKLNSNTRLQARNFQDWLWAISKVFTKDKLNFSYRFIGEDQLTREAIGELETKSPLQDSSQADNRQSDTIKEALEMLKEVEVYNTLHRAAIELPSVQTPSQIKKFYEPVMDMEGVEIAGQGQSVGKKISFDLPDFSTKEKVTGAEIGSATHELMQRIDLSQQLTLASLTETLKQVQTSQAVRDKINLDKILAFFDTVLGQEILANTDHLYREQPFSMLKRDQKSQEDFVVRGILDGYLLYENKIVLFDYKTDRYDEPSQLVDRYRGQLALYEEALSRAYSIENIEKYLILLGKDEVQVVKV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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