PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

⊟Summary

• pan ID^?: PNEUPAN003527000
• symbol^?: ply
• synonym:
• description^?: cholesterol-dependent cytolysin pneumolysin

  descriptions from strain specific annotations:

  • cholesterol-dependent cytolysin pneumolysin
  • pneumolysin
  • pneumolysin (Thiol-activated cytolysin)
  • intermedilysin
  • Pneumolysin (sulfhydryl-activated toxin that lyses cholesterol containing membranes)
  • Thiol-activated cytolysin
  • Thiol-activated cytolysin # pneumolysin
  • thiol-activated toxin pneumolysin
• strand^?: -
• coordinates^?: 4624826..4626241
• occurrence^?: in 98% of 43 strains

⊟Orthologs

(4)^?
TIGR4:
SP_RS09670 (ply)
(2)
D39:
SPD_RS09185 (ply)
(2)
D39V:
SPV_RS09180 (ply)
(19A)
Hungary19A-6:
SPH_RS10095 (ply)
(19F)
EF3030:
EF3030_RS09370 (ply)
(6B)^?
670-6B:
SP670_RS10075 (ply)
(6A)
6A-10:
HKM25_RS09700 (ply)
(5)
70585:
SP70585_RS09950 (ply)
(19F)
A026:
T308_RS09070 (ply)
(3)
A66:
A66_RS08680 (ply)
(11A)
AP200:
SPAP_RS09625 (ply)
(12F)
ASP0581:
EL334_RS09880 (ply)
(19F)
ATCC 49619:
EL263_RS09445 (ply)
(23F)
ATCC 700669:
SPN23F_RS09925 (ply)
(19F)
BM6001:
ODS73_RS10000 (ply)
(1)
BVJ1JL:
JN057_RS09390 (ply)
(14)
CGSP14:
SPCG_RS09950 (ply)
(19F)
G54:
SPG_RS09180 (ply)
(1)
gamPNI0373:
HMPREF1038_RS09390 (ply)
(3)
HU-OH:
EL271_RS09460 (ply)
(19A)
Hu15:
SPNHU15_RS09170 (ply)
(19A)
Hu17:
SPNHU17_RS09155 (ply)
(1)
INV104:
INV104_RS09620 (ply)
(14)
INV200:
SPNINV200_RS09365 (ply)
(14)
JJA:
SPJ_RS09520 (ply)
(19F)
MDRSPN001:
MDRSPN_RS08870 (ply)
(1)
NCTC7465:
AT689_RS04370 (ply)
(2)
NCTC7466:
DQM66_RS09180 (ply)
(4)
NU83127:
EL277_RS09855 (ply)
(3)
OXC141:
SPNOXC_RS09295 (ply)
(1)
P1031:
SPP_RS09630 (ply)
(2)
R6:
SPR_RS08750 (ply)
(19A)
SP49:
BMJ42_RS10320 (ply)
(1)
SPN032672:
SPN032672_RS06240 (ply)
(3)
SPN034156:
SPN034156_RS04250 (ply)
(3)
SPN034183:
SPN034183_RS09315 (ply)
(3)
SPN994038:
SPN994038_RS09220 (ply)
(3)
SPN994039:
SPN994039_RS09225 (ply)
(3)
SPNA45:
—
(19F)
ST556:
MYY_RS09510 (ply)
(19F)
Taiwan19F-14:
SPT_RS09315 (ply)
(19A)
TCH8431/19A:
HMPREF0837_RS10450 (ply)
(4)
Xen35:
CXP32_RS09795 (ply)

⊟Genome Viewer

TIGR4
D39
D39V
Hungary19A-6
EF3030

⊟Alignments

• alignment of orthologues:
  CLUSTAL format alignment by MAFFT L-INS-i (v7.505)
  
  
  TIGR4           MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFVVIERKKRSLSTNTSDI
  D39             MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFVVIERKKRSLSTNTSDI
  D39V            MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFVVIERKKRSLSTNTSDI
  Hungary19A-6    MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFVVIERKKRSLSTNTSDI
  EF3030          MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFVVIERKKRSLSTNTSDI
                  ************************************************************
  
  TIGR4           SVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSIDLPGLASSDSFLQVEDPSN
  D39             SVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSIDLPGLASSDSFLQVEDPSN
  D39V            SVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSIDLPGLASSDSFLQVEDPSN
  Hungary19A-6    SVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSIDLPGLASSDSFLQVEDPSN
  EF3030          SVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSIDLPGLASSDSFLQVEDPSN
                  ************************************************************
  
  TIGR4           SSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQLKVKFGSDFEKTGNSLDIDF
  D39             SSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQLKVKFGSDFEKTGNSLDIDF
  D39V            SSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQLKVKFGSDFEKTGNSLDIDF
  Hungary19A-6    SSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQLKVKFGSDFEKTGNSLDIDF
  EF3030          SSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQLKVKFGSDFEKTGNSLDIDF
                  ************************************************************
  
  TIGR4           NSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTVTVEDLKQRGISAERPLVYISSV
  D39             NSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTVTVEDLKQRGISAERPLVYISSV
  D39V            NSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTVTVEDLKQRGISAERPLVYISSV
  Hungary19A-6    NSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTVTVEDLKQRGISAERPLVYISSV
  EF3030          NSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTVTVEDLKQRGISAERPLVYISSV
                  ************************************************************
  
  TIGR4           AYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQTEWKQILDNTEVKAVILGGDPSSGA
  D39             AYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQTEWKQILDNTEVKAVILGGDPSSGA
  D39V            AYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQTEWKQILDNTEVKAVILGGDPSSGA
  Hungary19A-6    AYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQTEWKQILDNTEVKAVILGGDPSSGA
  EF3030          AYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQTEWKQILDNTEVKAVILGGDPSSGA
                  ************************************************************
  
  TIGR4           RVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTSFLRDNVVATFQNSTDYVETKVTAYRN
  D39             RVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTSFLRDNVVATFQNSTDYVETKVTAYRN
  D39V            RVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTSFLRDNVVATFQNSTDYVETKVTAYRN
  Hungary19A-6    RVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTSFLRDNVVATFQNSTDYVETKVTAYRN
  EF3030          RVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTSFLRDNVVATFQNSTDYVETKVTAYRN
                  ************************************************************
  
  TIGR4           GDLLLDHSGAYVAQYYITWNELSYDHQGKEVLTPKAWDRNGQDLTAHFTTSIPLKGNVRN
  D39             GDLLLDHSGAYVAQYYITWDELSYDHQGKEVLTPKAWDRNGQDLTAHFTTSIPLKGNVRN
  D39V            GDLLLDHSGAYVAQYYITWDELSYDHQGKEVLTPKAWDRNGQDLTAHFTTSIPLKGNVRN
  Hungary19A-6    GDLLLDHSGAYVAQYYITWDELSYDHQGKEVLTPKAWDRNGQDLTAHFTTSIPLKGNVRN
  EF3030          GDLLLDHSGAYVAQYYITWNELSYDHQGKEVLTPKAWDRNGQDLTAHFTTSIPLKGNVRN
                  *******************:****************************************
  
  TIGR4           LSVKIRECTGLAWEWWRTVYEKTDLPLVRKRTISIWGTTLYPQVEDKVEND
  D39             LSVKIRECTGLAWEWWRTVYEKTDLPLVRKRTISIWGTTLYPQVEDKVEND
  D39V            LSVKIRECTGLAWEWWRTVYEKTDLPLVRKRTISIWGTTLYPQVEDKVEND
  Hungary19A-6    LSVKIRECTGLAWEWWRTVYEKTDLPLVRKRTISIWGTTLYPQVEDKVEND
  EF3030          LSVKIRECTGLAWEWWRTVYEKTDLPLVRKRTISIWGTTLYPQVEDKVEND
                  ***************************************************