PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

⊟Summary

• pan ID^?: PNEUPAN003643000
• symbol^?: pbp2a
• synonym:
• description^?: penicillin-binding protein PBP2A

  descriptions from strain specific annotations:

  • penicillin-binding protein PBP2A
  • penicillin-binding protein 2A
  • Penicillin-binding protein 1F
  • penicillin-binding protein
  • Membrane carboxypeptidase (penicillin-binding protein)
  • Multimodular transpeptidase-transglycosylase
  • Multimodular transpeptidase-transglycosylase, penicillin-binding protein 2A
  • penicillin-binding, 1A family protein
  • penicillin-binding protein, 1A family
• strand^?: -
• coordinates^?: 4782388..4786366
• occurrence^?: in 100% of 43 strains

⊟Orthologs

(4)^?
TIGR4:
SP_RS10175 (pbp2a)
(2)
D39:
SPD_RS09695 (pbp2a)
(2)
D39V:
SPV_RS09690 (pbp2a)
(19A)
Hungary19A-6:
SPH_RS10605 (pbp2a)
(19F)
EF3030:
EF3030_RS09845 (pbp2a)
(6B)^?
670-6B:
SP670_RS10590 (pbp2a)
(6A)
6A-10:
HKM25_RS10150 (pbp2a)
(5)
70585:
SP70585_RS10420 (pbp2a)
(19F)
A026:
T308_RS09715 (pbp2a)
(3)
A66:
A66_RS09055 (pbp2a)
(11A)
AP200:
SPAP_RS10095 (pbp2a)
(12F)
ASP0581:
EL334_RS10370 (pbp2a)
(19F)
ATCC 49619:
EL263_RS09925 (pbp2a)
(23F)
ATCC 700669:
SPN23F_RS10425 (pbp2a)
(19F)
BM6001:
ODS73_RS10510 (pbp2a)
(1)
BVJ1JL:
JN057_RS09850 (pbp2a)
(14)
CGSP14:
SPCG_RS10425 (pbp2a)
(19F)
G54:
SPG_RS09635 (pbp2a)
(1)
gamPNI0373:
HMPREF1038_RS09855 (pbp2a)
(3)
HU-OH:
EL271_RS09980 (pbp2a)
(19A)
Hu15:
SPNHU15_RS09610 (pbp2a)
(19A)
Hu17:
SPNHU17_RS09600 (pbp2a)
(1)
INV104:
INV104_RS10105 (pbp2a)
(14)
INV200:
SPNINV200_RS09835 (pbp2a)
(14)
JJA:
SPJ_RS10015 (pbp2a)
(19F)
MDRSPN001:
MDRSPN_RS09535 (pbp2a)
(1)
NCTC7465:
AT689_RS03895 (pbp2a)
(2)
NCTC7466:
DQM66_RS09690 (pbp2a)
(4)
NU83127:
EL277_RS10375 (pbp2a)
(3)
OXC141:
SPNOXC_RS09755 (pbp2a)
(1)
P1031:
SPP_RS10095 (pbp2a)
(2)
R6:
SPR_RS09230 (pbp2a)
(19A)
SP49:
BMJ42_RS10845 (pbp2a)
(1)
SPN032672:
SPN032672_RS05740 (pbp2a)
(3)
SPN034156:
SPN034156_RS04760 (pbp2a)
(3)
SPN034183:
SPN034183_RS09775 (pbp2a)
(3)
SPN994038:
SPN994038_RS09680 (pbp2a)
(3)
SPN994039:
SPN994039_RS09685 (pbp2a)
(3)
SPNA45:
SPNA45_RS01215 (pbp2a)
(19F)
ST556:
MYY_RS10135 (pbp2a)
(19F)
Taiwan19F-14:
SPT_RS09935 (pbp2a)
(19A)
TCH8431/19A:
HMPREF0837_RS00055 (pbp2a)
(4)
Xen35:
CXP32_RS10310 (pbp2a)

⊟Genome Viewer

TIGR4
D39
D39V
Hungary19A-6
EF3030

⊟Alignments

• alignment of orthologues:
  CLUSTAL format alignment by MAFFT L-INS-i (v7.505)
  
  
  TIGR4           MKLDKLFEKFLSLFKKETSELEDSDSTILRRSRSDRKKLAQVGPIRKFWRRYHLTKIILI
  D39             MKLDKLFEKFLSLFKKETSELEDSDSTILRRSRSDRKKLAQVGPIRKFWRRYHLTKIILI
  D39V            MKLDKLFEKFLSLFKKETSELEDSDSTILRRSRSDRKKLAQVGPIRKFWRRYHLTKIILI
  Hungary19A-6    MKLDKLFEKFLSLFKKETSELEDSDSTILRRSRSDRKKLAQVGPIRKFWRRYHLTKIILI
  EF3030          MKLDKLFEKFLSLFKKETSELEDSDSTILRRSRSDRKKLAQVGPIRKFWRRYHLTKIILI
                  ************************************************************
  
  TIGR4           LGLSAGLLVGIYLFAVAKSTNVNDLQNALKTRTLIFDREEKEAGALSGQKGTYVELTDIS
  D39             LGLSAGLLVGIYLFAVAKSTNVNDLQNALKTRTLIFDREEKEAGALSGQKGTYVELTDIS
  D39V            LGLSAGLLVGIYLFAVAKSTNVNDLQNALKTRTLIFDREEKEAGALSGQKGTYVELTDIS
  Hungary19A-6    LGLSAGLLVGIYLFAVAKSTNVNDLQNALKTRTLIFDREEKEAGALSGQKGTYVELTDIS
  EF3030          LGLSAGLLVGIYLFAVAKSTNVNDLQNALKTRTLIFDREEKEAGALSGQKGTYVELTDIS
                  ************************************************************
  
  TIGR4           KNLQNAVIATEDRSFYKNDGINYGRFFLAIVTAGRSGGGSTITQQLAKNAYLSQDQTVER
  D39             KNLQNAVIATEDRSFYKNDGINYGRFFLAIVTAGRSGGGSTITQQLAKNAYLSQDQTVER
  D39V            KNLQNAVIATEDRSFYKNDGINYGRFFLAIVTAGRSGGGSTITQQLAKNAYLSQDQTVER
  Hungary19A-6    KNLQNAVIATEDRSFYKNDGINYGRFFLAIVTAGRSGGGSTITQQLAKNAYLSQDQTVER
  EF3030          KNLQNAVIATEDRSFYKNDGINYGRFFLAIVTAGRSGGGSTITQQLAKNAYLSQDQTVER
                  ************************************************************
  
  TIGR4           KAKEFFLALELSKKYSKEQILTMYLNNAYFGNGVWGVEDASKKYFGVSASEVSLDQAATL
  D39             KAKEFFLALELSKKYSKEQILTMYLNNAYFGNGVWGVEDASKKYFGVSASEVSLDQAATL
  D39V            KAKEFFLALELSKKYSKEQILTMYLNNAYFGNGVWGVEDASKKYFGVSASEVSLDQAATL
  Hungary19A-6    KAKEFFLALELSKKYSKEQILTMYLNNAYFGNGVWGVEDASKKYFGVSASEVSLDQAATL
  EF3030          KAKEFFLALELSKKYSKEQILTMYLNNAYFGNGVWGVEDASKKYFGVSASEVSLDQAATL
                  ************************************************************
  
  TIGR4           AGMLKGPELYNPLNSVEDSTNRRDTVLQNMVAAGYIDKNQETKAAEVDMTSQLHDKYEGK
  D39             AGMLKGPELYNPLNSVEDSTNRRDTVLQNMVAAGYIDKNQETEAAEVDMTSQLHDKYEGK
  D39V            AGMLKGPELYNPLNSVEDSTNRRDTVLQNMVAAGYIDKNQETEAAEVDMTSQLHDKYEGK
  Hungary19A-6    AGMLKGPELYNPLNSVEDSTNRRDTVLQNMVAAGYIDKNQETEAAEVDMASQLHDKYEGK
  EF3030          AGMLKGPELYNPLNSVEDSTNRRDTVLQNMVAAGYIDKNQETEAAEVDMTSQLHDKYEGK
                  ******************************************:******:**********
  
  TIGR4           ISDYRYPSYFDAVVNEAVSKYNLTEEEIVNNGYRIYTELDQNYQANMQIVYENTSLFPRA
  D39             ISDYRYPSYFDAVVNEAVSKYNLTEEEIVNNGYRIYTELDQNYQANMQIVYENTSLFPRA
  D39V            ISDYRYPSYFDAVVNEAVSKYNLTEEEIVNNGYRIYTELDQNYQANMQIVYENTSLFPRA
  Hungary19A-6    ISDYRYPSYFDAVVNEAVSKYNLTEEEIVNNGYRIYTELDQNYQANMQVVYENTSLFPRA
  EF3030          ISDYRYPSYFDAVVNEAVSKYNLTEEEIVNNGYRIYTELDQNYQANMQIVYENTSLFPRA
                  ************************************************:***********
  
  TIGR4           EDGTFAQSGSVALEPKTGGVRGVVGQVADNDKTGFRNFNYATQSKRSPGSTIKPLVVYTP
  D39             EDGTFAQSGSVALEPKTGGVRGVVGQVADNDKTGFRNFNYATQSKRSPGSTIKPLVVYTP
  D39V            EDGTFAQSGSVALEPKTGGVRGVVGQVADNDKTGFRNFNYATQSKRSPGSTIKPLVVYTP
  Hungary19A-6    EDGTFAQSGSVALEPKTGGVRGVVGQVADNDKTGFRNFNYATQSKRSPGSTIKPLVVYTP
  EF3030          EDGTFAQSGSVALEPKTGGVRGVVGQVADNDKTGFRNFNYATQSKRSPGSTIKPLVVYTP
                  ************************************************************
  
  TIGR4           AVEASWALNKQLDNHTMQYDSYKVDNYAGIKTSREVPMYQALAESLNLPAVATVNDLGVD
  D39             AVEAGWALNKQLDNHTMQYDSYKVDNYAGIKTSREVPMYQSLAESLNLPAVATVNDLGVD
  D39V            AVEAGWALNKQLDNHTMQYDSYKVDNYAGIKTSREVPMYQSLAESLNLPAVATVNDLGVD
  Hungary19A-6    AVEAGWALNKQLDNHTMQYDSYKVDNYAGIKTSREVPMYQALAESLNLPAVATVNDLGVD
  EF3030          AVEAGWALNKQLDNHTMQYDSYKVDNYAGIKTSREVPMYQALAESLNLPAVATVNDLGVD
                  ****.***********************************:*******************
  
  TIGR4           KAFEAGEKFGLNMEKVDRVLGVALGSGVETNPLQMAQAYAAFANEGLMPEAHFISRIENA
  D39             KAFEAGEKFGLNMEKVDRVLGVALGSGVETNPLQMAQAYAAFANEGLMPEAHFISRIENA
  D39V            KAFEAGEKFGLNMEKVDRVLGVALGSGVETNPLQMAQAYAAFANEGLMPEAHFISRIENA
  Hungary19A-6    KAFEAGEKFGLNMEKVDRVLGVALGSGVETNPLQMAQAYAAFANEGLMPEAHFISRIENA
  EF3030          KAFEAGEKFGLNMEKVDRVLGVALGSGVETNPLQMAQAYAAFANEGLMPEAHFISRIENA
                  ************************************************************
  
  TIGR4           SGQVIASHKNSQKRVIDKSVADKMTSMMLGTFTNGTGISSSPADYVMAGKTGTTEAVFNP
  D39             SGQVIASHKNSQKRVIDKSVADKMTSMMLGTFTNGTGISSSPADYVMAGKTGTTEAVFNP
  D39V            SGQVIASHKNSQKRVIDKSVADKMTSMMLGTFTNGTGISSSPADYVMAGKTGTTEAVFNP
  Hungary19A-6    SGQVIASHKNSQKRVIDKSVADKMTSMMLGTFTNGTGISSSPADYVMAGKTGTTEAVFNP
  EF3030          SGQVIASHKNSQKRVIDKSVADKMTSMMLGTFTNGTGISSSPADYIMAGKTGTTEAVFNP
                  *********************************************:**************
  
  TIGR4           EYTSDQWVIGYTPDVVISHWLGFPTTDENHYLAGSTSNGAAHVFRNIANTILPYTPGSTF
  D39             EYTSDQWVIGYTPDVVISHWLGFPTTDENHYLAGSTSNGAAHVFRNIANTILPYTPGSTF
  D39V            EYTSDQWVIGYTPDVVISHWLGFPTTDENHYLAGSTSNGAAHVFRNIANTILPYTPGSTF
  Hungary19A-6    EYTSDQWVIGYTPDVVISHWLGFPTTDENHYLAGSTSNGAAHVFRNIANTILPYTPGSTF
  EF3030          EYTSDQWVIGYTPDVVISHWLGFPTTDENHYLAGSTSNGAAHVFRNIANTILPYTPGSTF
                  ************************************************************
  
  TIGR4           TVENAYKQNGIAPANTKRQVQTNDNSQTDDNLSDIRGRAQSLVDEASRAISDAKIKEKAQ
  D39             TVENAYKQNGIAPANTKRQVQTNDNSQTDDNLSDIRGRAQSLVDEASRAISDAKIKEKAQ
  D39V            TVENAYKQNGIAPANTKRQVQTNDNSQTDDNLSDIRGRAQSLVDEASRAISDAKIKEKAQ
  Hungary19A-6    TVENAYKQNGIAPANTKRQVQTNDNSQTDDNLSDIRGRAQSLVDEASRAISDAKIKEKAQ
  EF3030          TVENAYKQNGIAPANTKRQVQTNDNSQTDDNLSDIRGRAQSLVDEASRAISDAKIKEKAQ
                  ************************************************************
  
  TIGR4           TIWDSIVNLFR
  D39             TIWDSIVNLFR
  D39V            TIWDSIVNLFR
  Hungary19A-6    TIWDSIVNLFR
  EF3030          TIWDSIVNLFR
                  ***********