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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 24-FEB-2025
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae SPN994038
- locus tag: SPN994038_RS09680 [old locus tag: SPN994038_17620 ]
- pan locus tag?: PNEUPAN003649000
- symbol: pbp2a
- pan gene symbol?: pbp2a
- synonym:
- product: penicillin-binding protein PBP2A
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SPN994038_RS09680 [old locus tag: SPN994038_17620 ]
- symbol: pbp2a
- product: penicillin-binding protein PBP2A
- replicon: chromosome
- strand: -
- coordinates: 1786747..1788942
- length: 2196
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: NC_021026 (1786747..1788942) NCBI
- BioCyc:
- MicrobesOnline:
- PneumoBrowse for strain D39V: SPV_1821 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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2161ATGAAATTAGATAAATTATTTGAGAAATTTCTTTCTCTTTTTAAAAAAGAAACAAGTGAA
TTAGAGGACTCTGATTCTACTATCTTACGTCGCTCTCGTAGTGATCGAAAAAAATTAGCC
CAAGTAGGTCCGATTCGAAAATTCTGGCGTCGTTATCATCTAACAAAGATTATCCTTATA
CTAGGTTTGAGTGCAGGCTTGCTAGTTGGAATCTATTTGTTTGCTGTAGCCAAGTCAACC
AATGTCAATGATTTGCAAAATGCCTTGAAAACTCGGACTCTTATTTTTGACCGTGAAGAA
AAAGAGGCTGGTGCCTTGTCTGGTCAAAAGGGAACCTATGTTGAGCTGACTGATATCAGT
AAAAACTTGCAGAATGCTGTTATTGCGACAGAAGACCGTTCTTTCTATAAAAATGACGGG
ATTAACTATGGCCGTTTCTTCTTGGCTATTGTCACTGCTGGACGTTCAGGTGGTGGCTCT
ACCATTACCCAACAGCTGGCTAAAAACGCCTATTTATCACAGGATCAAACTGTTGAGAGA
AAAGCGAAAGAATTTTTCCTTGCCTTAGAATTAAGCAAAAAATATAGTAAGGAGCAAATT
CTAACCATGTACCTTAACAACGCTTATTTTGGAAATGGTGTGTGGGGTGTAGAAGATGCG
AGTAAGAAATACTTTGGAGTTTCTGCATCAGAAGTGAGTCTGGATCAAGCTGCGACTCTG
GCAGGGATGCTCAAGGGGCCGGAACTGTATAATCCCTTGAATTCCGTAGAAGATTCTACT
AATCGGCGCGATACTGTCTTGCAGAATATGGTTGCAGCAGGATATATTGATAAAAACCAA
GAAACCGAAGCTGCTGAAGTTGATATGGCTTCGCAATTGCACGATAAGTATGAAGGAAAA
ATCTCAGATTACCGTTACCCCTCTTATTTTGATGCGGTGGTTAATGAAGCTGTTTCCAAG
TATAATCTAACAGAGGAAGAGATTGTCAATAATGGCTACCGCATTTACACAGAGCTGGAC
CAAAACTACCAAGCAAATATGCAGGTTGTTTATGAAAACACATCGCTATTTCCGAGGGCA
GAGGATGGAACGTTTGCTCAATCAGGAAGTGTAGCTCTCGAACCGAAAACAGGGGGAGTT
CGTGGAGTTGTCGGTCAAGTTGCTGACAATGATAAAACTGGATTCCGGAATTTCAACTAT
GCAACCCAATCAAAGCGTAGTCCTGGTTCTACAATTAAGCCTTTAGTTGTTTATACGCCA
GCAGTTGAAGCAGGCTGGGCTTTGAATAAGCAGTTGGATAACCATACCATGCAGTATGAC
AGCTATAAGGTTGATAACTATGCAGGGATCAAAACGAGTCGAGAAGTTCCTATGTATCAA
GCCTTGGCAGAATCGCTTAATCTACCTGCTGTTGCCACTGTTAATGATTTGGGTGTCGAC
AAGGCTTTTGAGGCAGGCGAAAAATTCGGACTCAACATGGAAAAGGTTGACCGTGTTCTT
GGTGTCGCCTTGGGAAGCGGTGTTGAAACCAACCCTCTTCAAATGGCTCAAGCATACGCC
GCCTTTGCAAATGAAGGTTTAATGCCTGAAGCTCATTTTATTAGTAGAATTGAAAATGCT
AGTGGACAAGTTATTGCGAGTCATAAAAATTCACAAAAACGGGTGATTGATAAGTCTGTA
GCTGACAAGATGACCAGTATGATGTTGGGGACTTTCACCAACGGTACCGGTATTAGTTCA
TCGCCTGCAGACTATGTCATGGCAGGGAAAACTGGAACAACTGAAGCAGTTTTCAATCCG
GAGTACACAAGTGACCAGTGGGTAATTGGTTATACTCCGGATGTAGTGATTAGCCACTGG
CTTGGCTTTCCGACCACTGATGAAAACCACTATCTAGCTGGCTCTACTTCAAACGGTGCA
GCTCATGTCTTTAGAAACATTGCCAATACCATTTTACCTTATACGTCAGGAAGTACCTTT
ACGGTTGAAAATGCTTATAAGCAAAATGGAATTGCACCAGCCAATACAAAAAGACAAGTA
CAAACCAATGATAATAGCCAGACAGATGATAATTTGTCTGATATTCGAGGGCGTGCGCAA
AGTCTAGTAGATGAGGCTAGCCGGGCTATCTCAGATGCGAAGATTAAGGAAAAGGCTCAA
ACAATATGGGATTCGATAGTCAATCTATTTCGCTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPN994038_RS09680 [old locus tag: SPN994038_17620 ]
- symbol: Pbp2a
- description: penicillin-binding protein PBP2A
- length: 731
- theoretical pI: 5.81291
- theoretical MW: 80727.9
- GRAVY: -0.414501
⊟Function[edit | edit source]
- TIGRFAM: Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan penicillin-binding protein, 1A family (TIGR02074; HMM-score: 543.9)and 6 moreCell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan penicillin-binding protein 1B (TIGR02071; HMM-score: 291.4)Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan penicillin-binding protein 1C (TIGR02073; HMM-score: 243)Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan monofunctional biosynthetic peptidoglycan transglycosylase (TIGR02070; EC 2.4.2.-; HMM-score: 130.8)Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan penicillin-binding protein 2 (TIGR03423; HMM-score: 66.9)Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan stage V sporulation protein D (TIGR02214; HMM-score: 41.5)Cellular processes Sporulation and germination stage V sporulation protein D (TIGR02214; HMM-score: 41.5)
- TheSEED: data available for D39, Hungary19A-6, TIGR4
- PFAM: Lysozyme (CL0037) Transgly; Transglycosylase (PF00912; HMM-score: 196.3)and 1 moreBeta-lactamase (CL0013) Transpeptidase; Penicillin binding protein transpeptidase domain (PF00905; HMM-score: 123.9)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic Membrane
- Cytoplasmic Score: 0.01
- Cytoplasmic Membrane Score: 9.99
- Cellwall Score: 0
- Extracellular Score: 0
- Internal Helices: 2
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.021397
- TAT(Tat/SPI): 0.013522
- LIPO(Sec/SPII): 0.006701
- predicted transmembrane helices (TMHMM): 1
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq: WP_000762611 NCBI
- UniProt:
⊟Protein sequence[edit | edit source]
- MKLDKLFEKFLSLFKKETSELEDSDSTILRRSRSDRKKLAQVGPIRKFWRRYHLTKIILILGLSAGLLVGIYLFAVAKSTNVNDLQNALKTRTLIFDREEKEAGALSGQKGTYVELTDISKNLQNAVIATEDRSFYKNDGINYGRFFLAIVTAGRSGGGSTITQQLAKNAYLSQDQTVERKAKEFFLALELSKKYSKEQILTMYLNNAYFGNGVWGVEDASKKYFGVSASEVSLDQAATLAGMLKGPELYNPLNSVEDSTNRRDTVLQNMVAAGYIDKNQETEAAEVDMASQLHDKYEGKISDYRYPSYFDAVVNEAVSKYNLTEEEIVNNGYRIYTELDQNYQANMQVVYENTSLFPRAEDGTFAQSGSVALEPKTGGVRGVVGQVADNDKTGFRNFNYATQSKRSPGSTIKPLVVYTPAVEAGWALNKQLDNHTMQYDSYKVDNYAGIKTSREVPMYQALAESLNLPAVATVNDLGVDKAFEAGEKFGLNMEKVDRVLGVALGSGVETNPLQMAQAYAAFANEGLMPEAHFISRIENASGQVIASHKNSQKRVIDKSVADKMTSMMLGTFTNGTGISSSPADYVMAGKTGTTEAVFNPEYTSDQWVIGYTPDVVISHWLGFPTTDENHYLAGSTSNGAAHVFRNIANTILPYTSGSTFTVENAYKQNGIAPANTKRQVQTNDNSQTDDNLSDIRGRAQSLVDEASRAISDAKIKEKAQTIWDSIVNLFR
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_1821 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
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