PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 31-JAN-2014

⊟Summary

• organism: Streptococcus pneumoniae 670-6B
• locus tag: SP670_0543 [new locus tag: SP670_RS02700 ]
• pan locus tag^?: PNEUPAN001320000
• symbol: SP670_0543
• pan gene symbol^?: rrgC
• synonym:
• product: cell wall surface anchor family protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SP670_0543 [new locus tag: SP670_RS02700 ]
• symbol: SP670_0543
• product: cell wall surface anchor family protein
• replicon: chromosome
• strand: +
• coordinates: 497153..498064
• length: 912
• essential: unknown

⊟Accession numbers

• Location: CP002176 (497153..498064) NCBI
• BioCyc: see SP670_RS02700
• MicrobesOnline:
• PneumoBrowse for strain D39V:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  
  ATGACCTTCCTTGAGAATCAGATTGAAGTATCTCATATTCCAAATGGTCTTTACTATGTT
  CGCTCTATTATCCAGACGGATGCGGTTTCTTATCCAGCTGAATTTCTTTTTGAAATGACA
  GATCAAACGGTAGAGCCTTTGGTCATTGTAGCGAAAAAAACAGATACAATGACAACAAAG
  GTGAAGCTGATAAAGGTGGATCAAGACCACAATCGCTTGGAGGGTGTCGGCTTTAAATTG
  GTATCAGTAGCAAGAGATGGTTCTGAAAAAGAGGTTCCCTTGATTGGAGAATACCGTTAC
  AGTTCTTCTGGTCAAGTAGGGAGAACTCTCTATACTGATAAAAATGGAGAGATTTTTGTG
  ACAAATCTTCCTCTTGGGAACTATCGTTTCAAGGAGGTGGAGCCACTGGCAGGCTATGCT
  GTTACGACGCTGGATACGGATGTCCAGCTGGTAGATCATCAGCTGGTGACGATTACGGTT
  GTCAATCAGAAATTACCACGTGGCAATGTTGACTTTATGAAGGTGGATGGTCGGACCAAT
  ACCTCTCTTCAAGGGGCAATGTTCAAAGTCATGAAAGAAGAAAGCGGACACTATACTCCT
  GTTCTTCAAAATGGTAAGGAAGTAGTTGTAACATCAGGGAAAGATGGTCGTTTCCGAGTG
  GAAGGTCTAGAGTATGGGACATACTATTTATGGGAGCTCCAAGCTCCAACTGGTTATGTT
  CAATTAACATCGCCTGTTTCCTTTACAATCGGGAAAGATACTCGTAAGGAACTGGTAACA
  GTGGTTAAAAATAACAAGCGACCACGGATTGATGTGCCAGATACAGGGGAAGAAACCTTG
  TATATCTTGATGCTTGTTGCCATTTTGTTGTTTGGTAGTGGTTATTATCTTACGAAAAAA
  CCAAATAACTGA
  60
  120
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  360
  420
  480
  540
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  840
  900
  912
  

⊟Protein

⊟General

• locus tag: SP670_0543 [new locus tag: SP670_RS02700 ]
• symbol: SP670_0543
• description: cell wall surface anchor family protein
• length: 303
• theoretical pI: 6.16412
• theoretical MW: 34054.7
• GRAVY: -0.254455

⊟Function

• TIGRFAM:
  Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 17.2)
• TheSEED  :
  • Cell wall surface anchor family protein, LPXTG motif
  Cell Wall and Capsule Gram-Positive cell wall components Sortase  Cell wall surface anchor family protein, LPXTG motif
• PFAM:
  Transthyretin (CL0287) SpaA; Prealbumin-like fold domain (PF17802; HMM-score: 110.1)
  and 8 more
  CarboxypepD_reg; Carboxypeptidase regulatory-like domain (PF13620; HMM-score: 23.7)
  SdrD_B; SdrD B-like domain (PF17210; HMM-score: 20.7)
  E-set (CL0159) Y_Y_Y; Y_Y_Y domain (PF07495; HMM-score: 16.5)
  Transthyretin (CL0287) EMC7_beta-sandw; ER membrane protein complex subunit 7, beta-sandwich domain (PF09430; HMM-score: 14.6)
  CarbopepD_reg_2; CarboxypepD_reg-like domain (PF13715; HMM-score: 13.4)
  CDA (CL0109) LpxI_C; LpxI C-terminal domain (PF06230; HMM-score: 13.3)
  no clan defined Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 13.2)
  E-set (CL0159) Por_Secre_tail; Secretion system C-terminal sorting domain (PF18962; HMM-score: 12.8)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helix: 1
• DeepLocPro: Cytoplasmic Membrane
  • Cytoplasmic Score: 0.0003
  • Cytoplasmic Membrane Score: 0.5526
  • Cell wall & surface Score: 0.4451
  • Extracellular Score: 0.0019
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.001788
  • TAT(Tat/SPI): 0.000102
  • LIPO(Sec/SPII): 0.000291
• predicted transmembrane helices (TMHMM): 1

⊟Accession numbers

• GI:
• RefSeq: ADM90614 NCBI
• UniProt:

⊟Protein sequence

• MTFLENQIEVSHIPNGLYYVRSIIQTDAVSYPAEFLFEMTDQTVEPLVIVAKKTDTMTTKVKLIKVDQDHNRLEGVGFKLVSVARDGSEKEVPLIGEYRYSSSGQVGRTLYTDKNGEIFVTNLPLGNYRFKEVEPLAGYAVTTLDTDVQLVDHQLVTITVVNQKLPRGNVDFMKVDGRTNTSLQGAMFKVMKEESGHYTPVLQNGKEVVVTSGKDGRFRVEGLEYGTYYLWELQAPTGYVQLTSPVSFTIGKDTRKELVTVVKNNKRPRIDVPDTGEETLYILMLVAILLFGSGYYLTKKPNN

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V:

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications