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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 670-6B
  • locus tag: SP670_2272 [new locus tag: SP670_RS11555 ]
  • pan locus tag?: PNEUPAN003677000
  • symbol: SP670_2272
  • pan gene symbol?: tktN
  • synonym:
  • product: transketolase, thiamine disphosphate-binding subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP670_2272 [new locus tag: SP670_RS11555 ]
  • symbol: SP670_2272
  • product: transketolase, thiamine disphosphate-binding subunit
  • replicon: chromosome
  • strand: -
  • coordinates: 2116129..2116986
  • length: 858
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGATTTTAAGTAAAAATAGAGAAGATGAGTTAAGAAAATTTGCGACTAACATCCGATTA
    AATACTCTTAGAACATTGAATCATCTTGGATTCGGACATTACGGAGGAAGTCTGTCTATC
    GTAGAAGTTTTAGCGGTGCTTTATGGTGAAATAATGCCAATGACTCCAGAAATATTTGCA
    GCACGAGATAGAGATTATTTCATATTATCAAAAGGTCATGGAGGACCAGCTCTATACAGT
    ACACTCTATTTGAATGGTTTCTTTGACAAAGAATTCTTATATTCTTTAAATACAAATGGA
    ACCAAATTACCGTCTCATCCTGATAGAAATCTAACGCCAGGCATAGATATGACAACGGGC
    TCTTTAGGACAAGGAATTAGTGTTGCAACTGGACTTGCATATGGTCAGAGAATAAGAAAG
    AGTCCCTTTTATACTTATGCTATTGTTGGAGATGGTGAGTTAAATGAGGGACAATGTTGG
    GAGGCTATACAGTTTGCTTCTCATCAACAGTTATCCAACTTAATTGTATTTGTTGATGAT
    AACAAAAAACAATTAGATGGTTTTACAAAGGATATTTGTAATCCAGGTGATTTCGTAGAA
    AAATTTTCAGCATTTGGATTTGAATCCATTAGGGTCAAGGGTTCAGATATTAGAGAAATT
    TATGAAGGGATTGTCCAATTAAAACAGTCAAATAATTCATCACCTAAGTGCATTGTATTA
    GATACTATTAAAGGTCAAGGGGTTCAAGAGCTGGAAGAAATGAAATCCAACCATCATCTT
    CGCCCTACTGTAGAGGAGAGACAAATGTTAACTTCAGTTGTAGAAAGATTAAGTCAGGAA
    TTGGAGGAAACAGAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    858

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP670_2272 [new locus tag: SP670_RS11555 ]
  • symbol: SP670_2272
  • description: transketolase, thiamine disphosphate-binding subunit
  • length: 285
  • theoretical pI: 5.40532
  • theoretical MW: 31983
  • GRAVY: -0.341053

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Energy metabolism Pentose phosphate pathway transketolase (TIGR00232; EC 2.2.1.1; HMM-score: 161.8)
    and 7 more
    Metabolism Energy metabolism Pyruvate dehydrogenase pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit (TIGR03182; EC 1.2.4.1; HMM-score: 52.7)
    pyruvate dehydrogenase (acetyl-transferring), homodimeric type (TIGR00759; EC 1.2.4.1; HMM-score: 46.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 39.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 39.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridoxine 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 39.3)
    Metabolism Energy metabolism Pyruvate dehydrogenase pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit (TIGR03181; EC 1.2.4.1; HMM-score: 39.2)
    alpha-ketoglutarate dehydrogenase (TIGR03186; HMM-score: 38.3)
  • TheSEED  :
    • Transketolase, N-terminal section (EC 2.2.1.1)
    Carbohydrates Central carbohydrate metabolism Pentose phosphate pathway  Transketolase, N-terminal section (EC 2.2.1.1)
  • PFAM:
    THDP-binding (CL0254) Transketolase_N; Transketolase, thiamine diphosphate binding domain (PF00456; HMM-score: 156.7)
    and 4 more
    DXP_synthase_N; 1-deoxy-D-xylulose-5-phosphate synthase (PF13292; HMM-score: 47.3)
    E1_dh; Dehydrogenase E1 component (PF00676; HMM-score: 30.6)
    XFP_N; XFP N-terminal domain (PF09364; HMM-score: 23.2)
    TPP_enzyme_C; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain (PF02775; HMM-score: 21.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.009201
    • TAT(Tat/SPI): 0.003105
    • LIPO(Sec/SPII): 0.001271
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADM92322 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MILSKNREDELRKFATNIRLNTLRTLNHLGFGHYGGSLSIVEVLAVLYGEIMPMTPEIFAARDRDYFILSKGHGGPALYSTLYLNGFFDKEFLYSLNTNGTKLPSHPDRNLTPGIDMTTGSLGQGISVATGLAYGQRIRKSPFYTYAIVGDGELNEGQCWEAIQFASHQQLSNLIVFVDDNKKQLDGFTKDICNPGDFVEKFSAFGFESIRVKGSDIREIYEGIVQLKQSNNSSPKCIVLDTIKGQGVQELEEMKSNHHLRPTVEERQMLTSVVERLSQELEETE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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