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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 670-6B
  • locus tag: SP670_RS00095 [old locus tag: SP670_0023 ]
  • pan locus tag?: PNEUPAN000017000
  • symbol: SP670_RS00095
  • pan gene symbol?: —
  • synonym:
  • product: helix-turn-helix transcriptional regulator

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP670_RS00095 [old locus tag: SP670_0023 ]
  • symbol: SP670_RS00095
  • product: helix-turn-helix transcriptional regulator
  • replicon: chromosome
  • strand: -
  • coordinates: 14307..14498
  • length: 192
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014498 (14307..14498) NCBI
  • BioCyc: SP670_RS00095 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    TTGCGTCTTACATTGAAAGCGTTGCGGGCTAATAGCAACATGAAACAATCAGAGGTAGCA
    CAAAAATTAGGAATTTCTACAACTACTTGGAGTAAGTGGGAAAATGGAAAAAGTTTTCCT
    GATGTTGCCCAAGTAAAAGAGATTGAAAAACTTTTCGGTGTTGCTTATGACGACATTATT
    TTTTTAAGCTAA
    60
    120
    180
    192

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP670_RS00095 [old locus tag: SP670_0023 ]
  • symbol: SP670_RS00095
  • description: helix-turn-helix transcriptional regulator
  • length: 63
  • theoretical pI: 9.84174
  • theoretical MW: 7134.19
  • GRAVY: -0.261905

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions DNA interactions transcriptional regulator, y4mF family (TIGR03070; HMM-score: 26.9)
    putative zinc finger/helix-turn-helix protein, YgiT family (TIGR03830; HMM-score: 26.8)
    and 7 more
    Hypothetical proteins Conserved TIGR00270 family protein (TIGR00270; HMM-score: 14.1)
    probable regulatory domain (TIGR03879; HMM-score: 13.8)
    EPS-associated transcriptional regulator, MarR family (TIGR04176; HMM-score: 13)
    Metabolism Amino acid biosynthesis Aromatic amino acid family trp operon repressor (TIGR01321; HMM-score: 12.9)
    Signal transduction Regulatory functions DNA interactions trp operon repressor (TIGR01321; HMM-score: 12.9)
    RNA polymerase sigma factor, sigma-70 family (TIGR02937; HMM-score: 12.7)
    RNA polymerase sigma-70 factor, sigma-B/F/G subfamily (TIGR02980; HMM-score: 11.9)
  • TheSEED: see SP670_0023
  • PFAM:
    HTH (CL0123) HTH_3; Helix-turn-helix (PF01381; HMM-score: 46.8)
    HTH_31; Helix-turn-helix domain (PF13560; HMM-score: 42.1)
    HTH_19; Helix-turn-helix domain (PF12844; HMM-score: 37.8)
    and 24 more
    HTH_26; Cro/C1-type HTH DNA-binding domain (PF13443; HMM-score: 23.3)
    HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 22.9)
    DUF1870; Domain of unknown function (DUF1870) (PF08965; HMM-score: 19.2)
    no clan defined RWP-RK; RWP-RK domain (PF02042; HMM-score: 18.7)
    HTH (CL0123) MqsA_antitoxin; Antitoxin component of bacterial toxin-antitoxin system, MqsA (PF15731; HMM-score: 18.3)
    HTH_Tnp_1_2; Helix-turn-helix of insertion element transposase (PF13022; HMM-score: 17.2)
    YdaS_antitoxin; Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT (PF15943; HMM-score: 16.5)
    HTH_23; Homeodomain-like domain (PF13384; HMM-score: 16)
    HTH_AsnC-type; AsnC-type helix-turn-helix domain (PF13404; HMM-score: 16)
    Phage_CI_repr; Bacteriophage CI repressor helix-turn-helix domain (PF07022; HMM-score: 14.8)
    no clan defined DUF5997; Family of unknown function (DUF5997) (PF19460; HMM-score: 14.6)
    HTH (CL0123) Xre-like-HTH; Antitoxin Xre-like helix-turn-helix domain (PF20432; HMM-score: 14.4)
    HTH_28; Helix-turn-helix domain (PF13518; HMM-score: 14)
    HTH_17; Helix-turn-helix domain (PF12728; HMM-score: 13.9)
    HTH_37; Helix-turn-helix domain (PF13744; HMM-score: 13.5)
    P22_Cro; DNA-binding transcriptional regulator Cro (PF14549; HMM-score: 13.2)
    Trp_repressor; Trp repressor protein (PF01371; HMM-score: 12.9)
    Sigma70_r4_2; Sigma-70, region 4 (PF08281; HMM-score: 12.9)
    HTH_10; HTH DNA binding domain (PF04967; HMM-score: 12.8)
    HTH_38; Helix-turn-helix domain (PF13936; HMM-score: 12.8)
    BetR; BetR domain (PF08667; HMM-score: 12.7)
    CENP-B_N; CENP-B N-terminal DNA-binding domain (PF04218; HMM-score: 11.8)
    Sigma70_r4; Sigma-70, region 4 (PF04545; HMM-score: 11.7)
    HTH_11; HTH domain (PF08279; HMM-score: 11.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.6278
    • Cytoplasmic Membrane Score: 0.218
    • Cell wall & surface Score: 0.0025
    • Extracellular Score: 0.1517
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.025137
    • TAT(Tat/SPI): 0.001884
    • LIPO(Sec/SPII): 0.006516
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001241280 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MRLTLKALRANSNMKQSEVAQKLGISTTTWSKWENGKSFPDVAQVKEIEKLFGVAYDDIIFLS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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