From PneumoWiki
Jump to navigation Jump to search
PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-OCT-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 670-6B
  • locus tag: SP670_RS04670 [old locus tag: SP670_0945 ]
  • pan locus tag?: PNEUPAN002665000
  • symbol: SP670_RS04670
  • pan gene symbol?: rpiR
  • synonym:
  • product: MurR/RpiR family transcriptional regulator

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP670_RS04670 [old locus tag: SP670_0945 ]
  • symbol: SP670_RS04670
  • product: MurR/RpiR family transcriptional regulator
  • replicon: chromosome
  • strand: +
  • coordinates: 878991..879800
  • length: 810
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014498 (878991..879800) NCBI
  • BioCyc: SP670_RS04670 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGTTACTGCAAAAAGAACTAATTCCAATGATAGAAGCTAACTTACCAAATATGGCATAT
    GCTGAAAAAGACATTGCTAAATTCTTCTTAAAACAGCAACCTCTGAATGATTATTCATCT
    AAAGCATTGTGCGAATACCTTAATGTATCCAAAGCAACATTGACTCGATTTGCGAAAAAA
    TGTGGTTTTAAAGGTTTTAGACAATTCATTTTCAAATACCAAGAGATGATTCATGAGAAA
    GAAAAGTTGGCATTATATACAGAGGCAACAGAAAAAGTTTTATCCGACTATGAGGAAATG
    TTGAGAAAAACTTACACGGTTCTTGATGAAGTTCAACTTGAGCGTATTGCTGAGATGATA
    GAAACTGCTGAGCGTGTATATCTCTACGGTAAAGGAAGTTCTGTTCTTGCTTTACAAGAA
    ATGAAGATGAGATTTATGCGTCTCGGAGTGATTGGTGAAGTATTATCAGACGAGGATATG
    ATTTTGTGGAGTAGCTTACTACTTAATGAAAATTGCCTTGTCATTGGAGCATCCATTTCA
    GGTCAAACTGATATTGTACTAGAAGGTCTACAAAAAGCTGCAGATAAAGGCGCTAAAACA
    GTTTTAATGACTACAAGAAAATTTGACGAAGAAGATTGTTTCTTTGATGAACTATTGTTA
    TTAGCTTCGACCGATCATCTCTCGTATGGCAATCGCATATCACCTCAGTTTCCAATACTT
    TTAATTACAGACTGCTTATTCTCTAATTATCTGGAAAGTCCAGAGAGACAATATTATTAC
    AATCAAACTATTATCCATAAGGAGGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    810

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP670_RS04670 [old locus tag: SP670_0945 ]
  • symbol: SP670_RS04670
  • description: MurR/RpiR family transcriptional regulator
  • length: 269
  • theoretical pI: 4.73074
  • theoretical MW: 31129.9
  • GRAVY: -0.169145

⊟Function[edit | edit source]

  • TIGRFAM:
    6-phospho 3-hexuloisomerase (TIGR03127; EC 5.3.-.-; HMM-score: 48.8)
    and 5 more
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides phosphoheptose isomerase (TIGR00441; EC 5.3.1.28; HMM-score: 15.9)
    bifunctional phosphoglucose/phosphomannose isomerase (TIGR02128; EC 5.3.1.9; HMM-score: 15.6)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan N-acetylmuramic acid 6-phosphate etherase (TIGR00274; EC 4.2.1.126; HMM-score: 14.1)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan glutamine-fructose-6-phosphate transaminase (isomerizing) (TIGR01135; EC 2.6.1.16; HMM-score: 11.4)
    Metabolism Central intermediary metabolism Amino sugars glutamine-fructose-6-phosphate transaminase (isomerizing) (TIGR01135; EC 2.6.1.16; HMM-score: 11.4)
  • TheSEED: see SP670_0945
  • PFAM:
    HTH (CL0123) HTH_6; Helix-turn-helix domain, rpiR family (PF01418; HMM-score: 43.3)
    SIS (CL0067) SIS; SIS domain (PF01380; HMM-score: 37.7)
    and 4 more
    SIS_2; SIS domain (PF13580; HMM-score: 23)
    HTH (CL0123) HTH_17; Helix-turn-helix domain (PF12728; HMM-score: 16.3)
    STAND_N (CL0587) Helo_like_N; Fungal N-terminal domain of STAND proteins (PF17111; HMM-score: 13.7)
    HTH (CL0123) HTH_11; HTH domain (PF08279; HMM-score: 12.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by RpiR*, TF important in Sialic acid utilization: in TIGR4

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.046562
    • TAT(Tat/SPI): 0.000904
    • LIPO(Sec/SPII): 0.000726
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000926537 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLLQKELIPMIEANLPNMAYAEKDIAKFFLKQQPLNDYSSKALCEYLNVSKATLTRFAKKCGFKGFRQFIFKYQEMIHEKEKLALYTEATEKVLSDYEEMLRKTYTVLDEVQLERIAEMIETAERVYLYGKGSSVLALQEMKMRFMRLGVIGEVLSDEDMILWSSLLLNENCLVIGASISGQTDIVLEGLQKAADKGAKTVLMTTRKFDEEDCFFDELLLLASTDHLSYGNRISPQFPILLITDCLFSNYLESPERQYYYNQTIIHKEE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=SP670_RS04670&oldid=18587"