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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 670-6B
  • locus tag: SP670_RS05085 [old locus tag: SP670_1029 ]
  • pan locus tag?: PNEUPAN002501000
  • symbol: smc
  • pan gene symbol?: smc
  • synonym:
  • product: chromosome segregation protein SMC

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP670_RS05085 [old locus tag: SP670_1029 ]
  • symbol: smc
  • product: chromosome segregation protein SMC
  • replicon: chromosome
  • strand: +
  • coordinates: 951625..955164
  • length: 3540
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_014498 (951625..955164) NCBI
  • BioCyc: SP670_RS05085 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1104 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    3301
    3361
    3421
    3481
    ATGTATTTAAAGGAAATCGAAATTCAGGGGTTCAAGTCTTTTGCTGATAAGACCAAGGTC
    GTTTTTGACCAAGGTGTGACGGCAGTTGTTGGACCCAATGGATCTGGAAAGTCCAATATT
    ACAGAAAGTCTGCGTTGGGCTTTGGGGGAGTCTAGTGTCAAGAGTCTCCGTGGGGGCAAG
    ATGCCGGATGTCATCTTTGCTGGAACAGAAAGTCGCAAACCGCTCAATTATGCTTCTGTA
    GTTGTGACTCTGGATAATCATGACGGATTTATCAAGGATGCAGGTCAAGAAATCAGGGTG
    GAACGCCATATCTATCGTAGTGGAGATAGCGAATACAAGATTGACGGCAAGAAAGTCCGT
    CTGCGTGATATTCATGACCTCTTCTTGGATACTGGATTGGGACGAGATTCCTTCTCTATT
    ATTTCCCAAGGGAAGGTTGAGGAGATTTTTAATTCCAAGCCTGAGGAACGACGAGCTATT
    TTTGAAGAAGCTGCTGGAGTTTTAAAATACAAGACTCGCAGAAAAGAAACCGAGAGTAAA
    CTGCAGCAAACTCAGGATAATCTGGACCGCTTAGAGGACATTATCTACGAGTTGGATAAT
    CAAATCAAGCCTCTTGAGAAGCAAGCTGAGAATGCCCGTAAGTTTTTAGACTTGGAAGGA
    CAACGTAAGGCTATTTATTTAGACGTTCTGGTTGCTCAAATCAAGGAAAATAAGGCAGAA
    CTAGAGTCGACAGAAGAAGAGTTGGCTCAGGTTCAAGAACTCTTGATGAGTTATTACCAA
    AAGCGTGAAAAATTAGAAGAAGAAAATCAAACTCTTAAAAAGCAACGCCAAGATTTACAG
    GCTGAAATGGCCAAAGACCAAGGCAGTTTGATGGACTTGACTAGTCTGATTAGTGATTTA
    GAAAGAAAATTAGCCCTATCGAAACTGGAGTCCGAGCAAGTGGCCCTGAATCAACAGGAG
    GCACAAGCTCGTTTGGCTGCTTTGGAGGATAAGAGAAATTCACTCAGCAAAGAAAAGTAT
    GATAAAGAAAGCTCTTTAGCTCTGTTAGAGGGAAATCTAGTCCAAAATAATCAAAAACTC
    AATCGTTTAGAAGCTGAATTGCTGGCTTTCTCAGACGATCCTGATCAGATGATTGAGCTC
    TTACGTGAACGCTTTGTAGCTCTTTTACAAGAAGAAGCGGATGTCTCAAACCAGTTGACC
    CGTATTGAGAATGAGTTGGAAAATAGTCGTCAGCTTTCTCAAAAACAAGCAGATCAACTA
    GAAAAGCTGAAAGAGCAATTAGCTACAGCTAAAGAGAAGGCTAGTCAGCAAAAAGACGAG
    CTTGAAACTGCCAAGGTGCAGGTTCAGAAATTATTGGCTGACTATCAAGCTATTGCCAAG
    GAGCAAGAGGAGCAGAAAACTTCCTATCAAGCTCAACAAAGTCAACTCTTTGACCGTCTG
    GATAGTCTCAAAAACAAGCAGGCCAGAGCTCAAAGTTTGGAAAATATCCTGAGAAATCAT
    AGTAACTTTTATGCAGGTGTTAAGAGTGTTCTCCAAGAAAAAGATCGCCTAGGTGGGATT
    ATTGGTGCAGTCAGTGAGCATCTGACCTTTGATGTTTATTATCAAACTGCCCTAGAGATT
    GCCTTAGGGGCAAGTAGCCAGCATATCATCGTAGAAGATGAAGAGTCGGCAACCAAAGCT
    ATTGATTTCCTCAAACGAAACAGAGTCGGTCGTGCAACCTTTCTTCCTTTGACCACTATT
    AAGGCGCGTACGATTTCTAGTCAGAACCAAGATGCTATCGCTGTAAGCCCAGGTTTCCTT
    GGGATGGCAGATGAGTTGGTGACTTTTGATACTAGACTGGAAGCCATTTTCAAGAACTTG
    CTAGCTACGACGGCTATCTTTGATACCGTAGAACATGCGCGTGAAGCTGCTCGACAAGTT
    CGTTATCAGGTTCGTATGGTGACATTGGATGGGACAGAATTACGCACGGGTGGTTCCTAT
    GCGGGTGGTGCCAATCGCCAAAATAACAGTATTTTCATCAAGCCAGAACTGGAGCAATTA
    CAAAAAGAAATTGCTGCAGATGAAGCAAGCTTGGGTTCAGAAGAAGCGGCTTTGAAGACC
    TTGCAAGACCAGATGGCTGCATTGACAGAAAGATTAGAAGCCATCAAATCTCAAGGAGAG
    CAGGCACGTATTCAGGAGCAAGGCTTGTCCCTCGCTTATCAGCAAACTAGTCAGCAAGTT
    GAAGAACTGGAAACTCTTTGGAAACTCCAAGAAGAGGAAATAGATCGTCTTTCTGAGGGA
    GATTGGCAAGCGGATAAGGAAAAATGTCAAGAGAGCCTTGCTACTATCGCCAGTGACAAG
    CAAAATCTGGAAGCTGAGATTGAAGAAATTAAGTCTAATAAAAACGCCATCCAAGAACGC
    TATCAAAATTTGCAGGAAGAGGTGGCGCAAGCTCGCTTGCTTAAGACAAAACTGCAAGGG
    CAAAAACGTTATGAAGTAGCTGATATTGAGCGTTTAGGCAAGGAATTGGACAATCTTAAT
    ATCGAACAAGAAGAAATTCAGCGCATGCTCCAAGAAAAAGTTGACAATCTTGAGAAGGTT
    GATACAGAATTGCTCAGTCAACAGGCGGAAGAATCCAAAACTCAGAAAACAAATCTCCAA
    CAAGGTTTGATTCGCAAGCAGTTTGAGTTGGATGATATAGAAGGTCAACTGGATGATATT
    GCCAGTCACTTGGATCAAGCTCGCCAGCAGAATGAGGAGTGGATTCGCAAGCAAACACGT
    GCTGAAGCCAAGAAAGAAAAGGTCAGCGAGCGCTTGCGCCATCTACAAAATCAATTAACA
    GACCAGTACCAGATTAGCTATACTGAAGCACTAGAAAAGGCACATGAATTGGAAAACCTC
    AATCTGGCAGAGCAAGAGGTGCAGGATTTAGAGAAGGCTATTCGCTCATTGGGACCTGTC
    AACTTGGAAGCTATTGACCAGTACGAAGAAGTTCACAACCGTCTGGACTTTCTAAATAGT
    CAGCGAGATGATATTTTGTCAGCGAAAAATCTGCTCCTTGAAACCATTACAGAGATGAAT
    GATGAGGTCAAGGAACGCTTTAAATCAACCTTTGAAGCTATTCGTGAGTCCTTTAAAGTG
    ACCTTCAAGCAGATGTTTGGCGGAGGTCAGGCAGACTTGATATTGACTGAGGGCGACCTT
    TTAACAGCTGGTGTGGAGATTTCTGTTCAACCTCCAGGTAAGAAAATCCAGTCGCTTAAC
    CTCATGAGTGGTGGTGAAAAAGCTCTATCGGCTCTTGCCTTGCTTTTCTCCATTATTCGT
    GTCAAGACCATTCCTTTTGTCATCTTGGATGAGGTGGAAGCTGCGCTGGATGAAGCCAAT
    GTTAAACGTTTTGGGGATTACCTCAACCGCTTTGACAAGGACAGCCAGTTTATCGTCGTA
    ACCCACCGTAAGGGAACCATGGCAGCGGCTGATTCCATCTATGGAGTGACCATGCAAGAA
    TCAGGTGTCTCAAAAATTGTTTCGGTTAAGTTAAAAGATTTAGAAAGTATTGAAGGATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2880
    2940
    3000
    3060
    3120
    3180
    3240
    3300
    3360
    3420
    3480
    3540

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP670_RS05085 [old locus tag: SP670_1029 ]
  • symbol: Smc
  • description: chromosome segregation protein SMC
  • length: 1179
  • theoretical pI: 4.64351
  • theoretical MW: 133843
  • GRAVY: -0.641645

⊟Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02168; HMM-score: 1083.5)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02168; HMM-score: 1083.5)
    and 15 more
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02169; HMM-score: 624)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02169; HMM-score: 624)
    thiol reductant ABC exporter, CydD subunit (TIGR02857; HMM-score: 30.6)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 25.4)
    Metabolism Transport and binding proteins Other lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 25.4)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA repair protein RecN (TIGR00634; HMM-score: 23)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other FeS assembly ATPase SufC (TIGR01978; HMM-score: 21.9)
    Metabolism Transport and binding proteins Other antigen peptide transporter 2 (TIGR00958; HMM-score: 21.3)
    Metabolism Transport and binding proteins Cations and iron carrying compounds cobalt ABC transporter, ATP-binding protein (TIGR01166; HMM-score: 20.1)
    ABC transporter, permease/ATP-binding protein (TIGR02204; HMM-score: 19.6)
    Metabolism Transport and binding proteins Anions phosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 19.5)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids glucan exporter ATP-binding protein (TIGR01192; EC 3.6.3.42; HMM-score: 15.5)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair exonuclease SbcC (TIGR00618; HMM-score: 14.8)
    helix-rich protein (TIGR04523; HMM-score: 13.6)
    rad50 (TIGR00606; HMM-score: 12.1)
  • TheSEED: see SP670_1029
  • PFAM:
    P-loop_NTPase (CL0023) SMC_N; RecF/RecN/SMC N terminal domain (PF02463; HMM-score: 197.2)
    and 5 more
    no clan defined SMC_hinge; SMC proteins Flexible Hinge Domain (PF06470; HMM-score: 86.5)
    P-loop_NTPase (CL0023) AAA_21; AAA domain, putative AbiEii toxin, Type IV TA system (PF13304; HMM-score: 53.9)
    AAA_15; AAA ATPase domain (PF13175; HMM-score: 42.7)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 17)
    AAA_18; AAA domain (PF13238; HMM-score: 12.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9847
    • Cytoplasmic Membrane Score: 0.004
    • Cell wall & surface Score: 0.0028
    • Extracellular Score: 0.0085
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.015986
    • TAT(Tat/SPI): 0.001628
    • LIPO(Sec/SPII): 0.002131
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000280930 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MYLKEIEIQGFKSFADKTKVVFDQGVTAVVGPNGSGKSNITESLRWALGESSVKSLRGGKMPDVIFAGTESRKPLNYASVVVTLDNHDGFIKDAGQEIRVERHIYRSGDSEYKIDGKKVRLRDIHDLFLDTGLGRDSFSIISQGKVEEIFNSKPEERRAIFEEAAGVLKYKTRRKETESKLQQTQDNLDRLEDIIYELDNQIKPLEKQAENARKFLDLEGQRKAIYLDVLVAQIKENKAELESTEEELAQVQELLMSYYQKREKLEEENQTLKKQRQDLQAEMAKDQGSLMDLTSLISDLERKLALSKLESEQVALNQQEAQARLAALEDKRNSLSKEKYDKESSLALLEGNLVQNNQKLNRLEAELLAFSDDPDQMIELLRERFVALLQEEADVSNQLTRIENELENSRQLSQKQADQLEKLKEQLATAKEKASQQKDELETAKVQVQKLLADYQAIAKEQEEQKTSYQAQQSQLFDRLDSLKNKQARAQSLENILRNHSNFYAGVKSVLQEKDRLGGIIGAVSEHLTFDVYYQTALEIALGASSQHIIVEDEESATKAIDFLKRNRVGRATFLPLTTIKARTISSQNQDAIAVSPGFLGMADELVTFDTRLEAIFKNLLATTAIFDTVEHAREAARQVRYQVRMVTLDGTELRTGGSYAGGANRQNNSIFIKPELEQLQKEIAADEASLGSEEAALKTLQDQMAALTERLEAIKSQGEQARIQEQGLSLAYQQTSQQVEELETLWKLQEEEIDRLSEGDWQADKEKCQESLATIASDKQNLEAEIEEIKSNKNAIQERYQNLQEEVAQARLLKTKLQGQKRYEVADIERLGKELDNLNIEQEEIQRMLQEKVDNLEKVDTELLSQQAEESKTQKTNLQQGLIRKQFELDDIEGQLDDIASHLDQARQQNEEWIRKQTRAEAKKEKVSERLRHLQNQLTDQYQISYTEALEKAHELENLNLAEQEVQDLEKAIRSLGPVNLEAIDQYEEVHNRLDFLNSQRDDILSAKNLLLETITEMNDEVKERFKSTFEAIRESFKVTFKQMFGGGQADLILTEGDLLTAGVEISVQPPGKKIQSLNLMSGGEKALSALALLFSIIRVKTIPFVILDEVEAALDEANVKRFGDYLNRFDKDSQFIVVTHRKGTMAAADSIYGVTMQESGVSKIVSVKLKDLESIEG

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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